Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

Gupta, Saumya Shree; Maetzig, Tobias; Maertens, Goedele N.; Sharif, Azar; Rothe, Michael; Weidner-Glunde, Magdalena; Galla, Melanie; Schambach, Axel; Cherepanov, Peter; Schulz, Thomas F.

doi:10.1128/jvi.01942-13

Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration

Retroviral integrase (IN) proteins catalyze the permanent integration of proviral genomes into host DNA with the help of cellular cofactors. Lens epithelium-derived growth factor (LEDGF) is a cofactor for lentiviruses, including human immunodeficiency virus type 1 (HIV-1), and targets lentiviral …