Iwakuma, Tomoo

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome

Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell

Cancer-related Molecular PathwaysChromatin Remodeling and Cancer

Cited by 1,069

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

Pant, V., Xiong, S., Iwakuma, T., Quintás-Cardama, A., & Lozano, G. (2011) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 134

A High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development

Post, S. M., Quintás-Cardama, A., Pant, V., Iwakuma, T., Hamir, A., Jackson, J. G., Maccio, D. R., Bond, G. L., Johnson, D. G., Levine, A. J., et al. (2010) · Cancer Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 127

Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389

Bruins, W., Zwart, E., Attardi, L. D., Iwakuma, T., Hoogervorst, E. M., Beems, R. B., Miranda, B., van Oostrom, C. T. M., van den Berg, J., van den Aardweg, G. J., et al. (2004) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 121

Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials

Nishikawa, S., & Iwakuma, T. (2023) · Cancers

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 115

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway

Busso, C. S., Iwakuma, T., & Izumi, T. (2009) · Oncogene

Ubiquitin and proteasome pathwaysDNA Repair Mechanisms

Cited by 100