Tiganis, Tony

Reactive oxygen species enhance insulin sensitivity

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism

Redox biology and oxidative stressMetabolism, Diabetes, and Cancer

Cited by 581

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 398

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., et al. (2018) · Cell

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 373

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., et al. (2018) · Cell Reports

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 262

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

Tiganis, T. (2011) · Trends in Pharmacological Sciences

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 256

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Gurzov, E. N., Tran, M., Fernandez-Rojo, M. A., Merry, T. L., Zhang, X., Xu, Y., Fukushima, A., Waters, M. J., Watt, M. J., Andrikopoulos, S., et al. (2014) · Cell Metabolism

Protein Tyrosine PhosphatasesMetabolism, Diabetes, and Cancer

Cited by 111

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

Xirouchaki, C. E., Jia, Y., McGrath, M. J., Greatorex, S., Tran, M., Merry, T. L., Hong, D., Eramo, M. J., Broome, S. C., Woodhead, J. S. T., et al. (2021) · Science Advances

Redox biology and oxidative stressExercise and Physiological Responses

Cited by 107

The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism

Hao, L., Tiganis, T., Tonks, N. K., & Charbonneau, H. (1997) · Journal of Biological Chemistry

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 78

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A., & Tiganis, T. (2017) · Cell Metabolism

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 66

Leptin Signaling in the Arcuate Nucleus Reduces Insulin’s Capacity to Suppress Hepatic Glucose Production in Obese Mice

Balland, E., Chen, W., Dodd, G. T., Conductier, G., Coppari, R., Tiganis, T., & Cowley, M. A. (2019) · Cell Reports

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 44

miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression

Fernández-Tussy, P., Cardelo, M. P., Zhang, H., Sun, J., Price, N. L., Boutagy, N. E., Goedeke, L., Cadena-Sandoval, M., Xirouchaki, C. E., Brown, W., et al. (2024) · JCI Insight

Liver Disease Diagnosis and TreatmentMicroRNA in disease regulation

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