Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus.

DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296 · see citing works

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works

Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

Postic, C., & Girard, J. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,200 · see citing works

Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects

Møller, N., & Jørgensen, J. O. L. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0027 · Cited by 1,040 · see citing works

Selective versus Total Insulin Resistance: A Pathogenic Paradox

Brown, M. S., & Goldstein, J. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.009 · Cited by 959 · see citing works

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

Rolo, A. P., Teodoro, J. S., & Palmeira, C. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.003 · Cited by 955 · see citing works

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S., & Goldstein, J. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119248 · Cited by 842 · see citing works

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

Foretz, M., Guichard, C., Ferré, P., & Foufelle, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12737 · Cited by 748 · see citing works

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733 · cited 1× · see citing works

Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

Newsholme, P., Haber, E. P., Hirabara, S. M., Rebelato, E. L. O., Procopio, J., Morgan, D., Oliveira‐Emilio, H. C., Carpinelli, A. R., & Curi, R. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135871 · Cited by 684 · see citing works

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 662 · see citing works

The Origins and Drivers of Insulin Resistance

Johnson, A. M. F., & Olefsky, J. M. (2013) · Cell · doi:10.1016/j.cell.2013.01.041 · Cited by 639 · see citing works

Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

Matsusue, K., Haluzı́k, M., Lambert, G. C., Yim, S.-H., Gavrilova, O., Ward, J. M., Brewer, B., Reitman, M. L., & Gonzalez, F. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317223 · Cited by 636 · see citing works

Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor γ1 (PPARγ1) Overexpression

Yu, S., Matsusue, K., Kashireddy, P. V., Cao, W.-Q., Yeldandi, V., Yeldandi, A. V., Rao, M. S., Gonzalez, F. J., & Reddy, J. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210062200 · Cited by 621 · see citing works

Reactive oxygen species enhance insulin sensitivity

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.013 · Cited by 469 · see citing works

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

He, G., Yu, G.-Y., Temkin, V., Ogata, H., Kuntzen, C., Sakurai, T., Sieghart, W., Peck-Radosavljevic, M., Leffert, H. L., & Karin, M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.048 · Cited by 427 · see citing works

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Lu, M., Wan, M., Leavens, K. F., Chu, Q., Monks, B. R., Fernandez, S., Ahima, R. S., Ueki, K., Kahn, C. R., & Birnbaum, M. J. (2012) · Nature Medicine · doi:10.1038/nm.2686 · Cited by 396 · see citing works

Role for PPARγ in obesity‐induced hepatic steatosis as determined by hepatocyte‐ and macrophage‐specific conditional knockouts

Morán‐Salvador, E., López‐Parra, M., García‐Alonso, V., Titos, E., Martínez‐Clemente, M., González‐Périz, A., López‐Vicario, C., Barak, Y., Arroyo, V., & Clària, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-173716 · Cited by 388 · see citing works

Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone

Nam, S., Lee, E. J., Kim, K., Cha, B., Song, Y., Lim, S., Lee, H., & Kb, H. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800412 · Cited by 385 · see citing works

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

Aoyama, T., Paik, Y.-H., Watanabe, S., Laleu, B., Gaggini, F., Fioraso-Cartier, L., Molango, S., Heitz, F., Merlot, C., Szyndralewiez, C., et al. (2012) · Hepatology · doi:10.1002/hep.25938 · Cited by 336 · see citing works

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316 · cited 3× · see citing works

Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-α) and PPAR-γ Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-γ-Responsive Adipose Tissue-Specific Genes in the Liver of Obese Diabetic Mice**This work was supported by grants from the Research Service of the Department of Veterans Affairs (to C.G. and K.R.F.), NIH Grant DK-49448 (to C.G.), and Merck Research Laboratories (to L.H.T. and K.N.).

Memon, R. A., Tecott, L. H., Nonogaki, K., Beigneux, A. P., Moser, A. H., Grünfeld, C., & Feingold, K. R. (2000) · Endocrinology · doi:10.1210/endo.141.11.7771 · Cited by 302 · see citing works

Protein tyrosine phosphatase function: the substrate perspective

Tiganis, T., & Bennett, A. M. (2007) · Biochemical Journal · doi:10.1042/bj20061548 · Cited by 299 · see citing works

Dietary Factors Alter Hepatic Innate Immune System in Mice With Nonalcoholic Ratty Liver Disease * #

Li, Z., Soloski, M. J., & Diehl, A. M. (2005) · Hepatology · doi:10.1002/hep.20826 · Cited by 294 · see citing works

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

Leavens, K. F., Easton, R., Shulman, G. I., Previs, S. F., & Birnbaum, M. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.004 · Cited by 278 · see citing works

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

Delibegović, M., Zimmer, D. J., Kauffman, C., Rak, K. J., Hong, E., Cho, Y.-R., Kim, J. K., Kahn, B. B., Neel, B. G., & Bence, K. K. (2008) · Diabetes · doi:10.2337/db08-0913 · Cited by 277 · see citing works

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

Tiganis, T. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.006 · Cited by 256 · see citing works

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

Wiede, F., Shields, B. J., Chew, S., Kyparissoudis, K., van Vliet, C., Galić, S., Tremblay, M. L., Russell, S. M., Godfrey, D. I., & Tiganis, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59492 · Cited by 225 · see citing works

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

Haas, J. T., Miao, J., Chanda, D., Wang, Y., Zhao, E., Haas, M. E., Hirschey, M. D., Vaitheesvaran, B., Farese, R. V., Kurland, I. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.002 · Cited by 207 · see citing works

PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis

Tiganis, T. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08563.x · Cited by 205 · see citing works

Association between the Insulin Resistance of Puberty and the Insulin-Like Growth Factor-I/Growth Hormone Axis

Moran, A., Jacobs, D. R., Steinberger, J., Cohen, P., Hong, C.-P., Prineas, R. J., & Sinaiko, A. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020517 · Cited by 204 · see citing works

The Nicotinamide Adenine Dinucleotide Phosphate Oxidase Homologues NOX1 and NOX2/gp91phox Mediate Hepatic Fibrosis in Mice

Paik, Y., Iwaisako, K., Seki, E., Inokuchi, S., Schnabl, B., Österreicher, C. H., Kisseleva, T., & Brenner, D. A. (2011) · Hepatology · doi:10.1002/hep.24281 · Cited by 195 · see citing works

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration†

Cui, Y., Hosui, A., Sun, R., Shen, K., Gavrilova, O., Chen, W., Cam, M. C., Gao, B., Robinson, G. W., & Hennighausen, L. G. (2007) · Hepatology · doi:10.1002/hep.21713 · Cited by 184 · see citing works

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Loh, K., Fukushima, A., Zhang, X., Galić, S., Briggs, D. I., Enriori, P. J., Simonds, S. E., Wiede, F., Reichenbach, A., Hauser, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.011 · Cited by 180 · see citing works

Global proteomic assessment of the classical protein-tyrosine phosphatome and “Redoxome”

Karisch, R., Fernandez, M., Taylor, P., Virtanen, C., St-Germain, J. R., Jin, L. L., Harris, I. S., Mori, J., Mak, T. W., Senis, Y. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.020 · Cited by 179 · see citing works

GH-Dependent STAT5 Signaling Plays an Important Role in Hepatic Lipid Metabolism

Barclay, J. L., Nelson, C. N., Ishikawa, M., Murray, L. A., Kerr, L. M., McPhee, T. R., Powell, E. E., & Waters, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0537 · Cited by 176 · see citing works

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

Hermiston, M. L., Zikherman, J., & Zhu, J. W. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00752.x · Cited by 170 · see citing works

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

Donahue, L. R., & Beamer, W. G. (1993) · Journal of Endocrinology · doi:10.1677/joe.0.1360091 · Cited by 169 · see citing works

In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts

Rowland, J., Lichanska, A. M., Kerr, L. M., White, M. E., d’Aniello, E., Maher, S., Brown, R. J. P., Teasdale, R. D., Noakes, P. G., & Waters, M. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.66-77.2005 · Cited by 152 · see citing works

How growth hormone controls growth, obesity and sexual dimorphism

Lichanska, A. M., & Waters, M. J. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.10.006 · Cited by 126 · see citing works

Stat5 is a physiological substrate of the insulin receptor

Chen, J., Sadowski, H. B., Kohanski, R. A., & Wang, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2295 · Cited by 124 · see citing works

Effects of Insulin on Rat Anterior Pituitary Cells: Inhibition of Growth Hormone Secretion and mRNA Levels

Yamashita, S., & Melmed, S. K. (1986) · Diabetes · doi:10.2337/diab.35.4.440 · Cited by 121 · see citing works

Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells

Lou, Y., Chen, Y., Hsu, S.-F., Chen, R., Lee, C., Khoo, K., Tonks, N. K., & Meng, T. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06173.x · Cited by 112 · see citing works

Obesity, growth hormone and weight loss

Rasmussen, M. H. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.017 · Cited by 111 · see citing works

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

Kanashiro‐Takeuchi, R. M., Τζιόμαλος, Κ., Takeuchi, L. M., Treuer, A. V., Lamirault, G., Dulce, R. A., Hurtado, M., Song, Y. G., Block, N. L., Rick, F. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914138107 · Cited by 107 · see citing works

Differential redox regulation within the PTP superfamily

Ross, S. H., Lindsay, Y. E., Safrany, S. T., Lorenzo, Ó., Villa, F., Toth, R. L., Clague, M. J., Downes, C. P., & Leslie, N. R. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.01.026 · Cited by 101 · see citing works

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Fukushima, A., Loh, K., Galić, S., Fam, B. C., Shields, B., Wiede, F., Tremblay, M. L., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2010) · Diabetes · doi:10.2337/db09-1365 · Cited by 91 · see citing works

The Effect of Simple Obesity on Growth and Growth Hormone

Vanderschueren‐Lodeweyckx, M. (2008) · Hormone Research · doi:10.1159/000183763 · Cited by 71 · see citing works

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Merry, T. L., Tran, M., Stathopoulos, M., Wiede, F., Fam, B. C., Dodd, G. T., Clarke, I. J., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5428 · Cited by 69 · see citing works

Systemic upregulation of NADPH oxidase in diet-induced obesity in rats

Jiang, F., Lim, H. K., Morris, M. J., Prior, L. J., Velkoska, E., Wu, X. L., & Dusting, G. J. (2011) · Redox Report · doi:10.1179/174329211x13049558293713 · Cited by 68 · see citing works

Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model

Romero, C. J., Ng, Y., Luque, R. M., Kineman, R. D., Koch, L., Brüning, J. C., & Radovick, S. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0393 · Cited by 60 · see citing works

The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes

White, U. A., Coulter, A. A., Miles, T. K., & Stephens, J. M. (2007) · Diabetes · doi:10.2337/db06-1286 · Cited by 59 · see citing works

Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy

Snel, Y. E. M., Doerga, M. E., Brummer, R. J., ZELISSEN, P. M. J., Zonderland, M. L., & Koppeschaar, H. P. F. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1330445 · Cited by 50 · see citing works

Gut and the Induction of Immune Tolerance in Type 1 Diabetes

Vaarala, O. (1999) · Diabetes/Metabolism Research and Reviews · doi:10.1002/(sici)1520-7560(199909/10)15:5 · Cited by 47 · see citing works

An antibody-based method for monitoring in vivo oxidation of protein tyrosine phosphatases

PERSSON, C., Kappert, K., Engström, U., Östman, A., & Sjöblom, T. (2004) · Methods · doi:10.1016/j.ymeth.2004.07.006 · Cited by 47 · see citing works

Calorigenic effects of growth hormone: the role of thyroid hormones

Wolthers, T., Grøftne, T., Møller, N., Christiansen, J. S., Ørskov, H., Weeke, J., & Jørgensen, J. O. L. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636344 · Cited by 47 · see citing works

Role of hepatic STAT3 in the regulation of lipid metabolism.

Kinoshita, S., Ogawa, W., Okamoto, Y., Takashima, M., Inoue, H., Matsuki, Y., Watanabe, E., Hiramatsu, R., & Kasuga, M. (2008) · PubMed · doi:10.24546/81000870 · Cited by 43 · see citing works

Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain

Steyn, F. J., Xie, T. Y., Huang, L., Ngo, S. T., Veldhuis, J. D., Waters, M. J., & Chen, C. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0084 · Cited by 41 · see citing works

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner

Kim, Y. D., Kim, Y., Tadi, S., Yu, J. H., Yim, Y., Jeoung, N. H., Shong, M., Hennighausen, L. G., Harris, R. A., Lee, I., et al. (2012) · Diabetes · doi:10.2337/db11-1665 · Cited by 28 · see citing works

Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases

Sandin, Å., Dagnell, M., Gonon, A. T., Pernow, J., Stangl, V., Aspenström, P., Kappert, K., & Östman, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.004 · Cited by 26 · see citing works

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

Miraldi, E. R., Sharfi, H., Friedline, R. H., Johnson, H., Zhang, T., Lau, K. S., Ko, H. J., Curran, T. G., Haigis, K. M., Yaffe, M. B., et al. (2013) · Integrative Biology · doi:10.1039/c3ib40013a · Cited by 25 · see citing works

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

Loh, K., Merry, T. L., Galić, S., Wu, B. J., Watt, M. J., Zhang, S., Zhang, Z., Neel, B. G., & Tiganis, T. (2011) · Diabetologia · doi:10.1007/s00125-011-2386-z · Cited by 25 · see citing works

Dual Mechanism of Signal Transducer and Activator of Transcription 5 Activation by the Insulin Receptor

Le, M. N., Kohanski, R. A., Wang, L., & Sadowski, H. B. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0017 · Cited by 21 · see citing works

Insulin hypoglycemia and growth hormone secretion in sheep: a paradox revisited

Jaffe, C. A., Huffman, B. W., & DeMott-Friberg, R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e253 · Cited by 12 · see citing works

Morbidity and mortality associated with obesity

Abdelaal, M., le Roux, C. W., & Docherty, N. G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.03.107 · Cited by 1,052 · see citing works

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.053 · Cited by 373 · see citing works

STAT proteins in cancer: orchestration of metabolism

Li, Y., Zhang, C., Martincuks, A., Herrmann, A., & Yu, H. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-022-00537-3 · Cited by 287 · see citing works

The JAK / STAT pathway in obesity and diabetes

Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016) · FEBS Journal · doi:10.1111/febs.13709 · Cited by 253 · see citing works

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

Chattopadhyay, M., Khemka, V. K., Chatterjee, G., Ganguly, A., Mukhopadhyay, S., & Chakrabarti, S. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2236-7 · Cited by 171 · see citing works

PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours

Wiede, F., Lu, K., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C. J., Meyran, D., Beavis, P. A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2019103637 · Cited by 140 · see citing works

Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk

Ogawa-Wong, A. N., Berry, M. J., & Seale, L. A. (2016) · Nutrients · doi:10.3390/nu8020080 · Cited by 125 · see citing works

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

Xirouchaki, C. E., Jia, Y., McGrath, M. J., Greatorex, S., Tran, M., Merry, T. L., Hong, D., Eramo, M. J., Broome, S. C., Woodhead, J. S. T., et al. (2021) · Science Advances · doi:10.1126/sciadv.abl4988 · Cited by 107 · see citing works

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Lückel, C., Picard, F. S. R., Raifer, H., Carrascosa, L. C., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13731-z · Cited by 104 · see citing works

Protein tyrosine phosphatases: molecular switches in metabolism and diabetes

Gurzov, E. N., Stanley, W. J., Brodnicki, T. C., & Thomas, H. E. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.10.004 · Cited by 97 · see citing works

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

Liang, S., Tran, E., Du, X., Dong, J., Sudholz, H., Chen, H., Qu, Z., Huntington, N. D., Babon, J. J., Kershaw, N. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40170-8 · Cited by 96 · see citing works

The Interconnection between Hepatic Insulin Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease—The Transition from an Adipocentric to Liver-Centric Approach

Vesković, M. N., Šutulović, N., Hrnčić, D., Stanojlović, O. P., Μacut, D., & Mladenović, D. R. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110570 · Cited by 91 · see citing works

Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

Brahma, M. K., Gilglioni, E. H., Zhou, L., Trépo, E., Chen, P., & Gurzov, E. N. (2021) · Oncogene · doi:10.1038/s41388-021-01950-y · Cited by 84 · see citing works

Towards a comprehensive theory of obesity and a healthy diet: The causal role of oxidative stress in food addiction and obesity

Tobore, T. O. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112560 · Cited by 73 · see citing works

Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats

Rahmani, A. H., Alsahli, M. A., Khan, A. A., & Almatroodi, S. A. (2023) · Metabolites · doi:10.3390/metabo13010130 · Cited by 70 · see citing works

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

Krishnan, N., Bonham, C. A., Rus, I. A., Shrestha, O. K., Gauss, C. M., Haque, A., Tocilj, A., Joshua‐Tor, L., & Tonks, N. K. (2018) · Nature Communications · doi:10.1038/s41467-017-02252-2 · Cited by 66 · see citing works

Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma

Talamantes, S., Lisjak, M., Gilglioni, E. H., Llamoza-Torres, C. J., Ramos‐Molina, B., & Gurzov, E. N. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100811 · Cited by 60 · see citing works

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity

Greatorex, S., Kaur, S., Xirouchaki, C. E., Goh, P. K., Wiede, F., Genders, A., Tran, M., Jia, Y., Raajendiran, A., Brown, W., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162533 · Cited by 50 · see citing works

Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review

Li, J., Bai, L., Wei, F., Zhao, J., Wang, D., Xiao, Y., Yan, W., & Wei, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00661 · Cited by 58 · see citing works

PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

Goh, P. K., Wiede, F., Zeissig, M. N., Britt, K. L., Liang, S., Molloy, T., Goode, N., Xu, R., Loi, S., Müller, M. M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk3338 · Cited by 56 · see citing works

Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma

Atabay, E. K., Mecca, C., Wang, Q., Ambrogio, C., Mota, I. A., Prokoph, N., Mura, G., Martinengo, C., Patrucco, E., Leonardi, G. C., et al. (2021) · Blood · doi:10.1182/blood.2020008136 · Cited by 51 · see citing works

Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways

Liu, Y., Tan, S. H., Zhang, H., Kong, X., Ding, L., Shen, J., Yan, L., Cheng, C., Zhu, T., & Xia, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-08792-3 · Cited by 49 · see citing works

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

Dodd, G. T., Lee, R. S., Brüning, J. C., & Tiganis, T. (2018) · Diabetes · doi:10.2337/db17-1485 · Cited by 46 · see citing works

The Role of the Growth Hormone/Insulin-Like Growth Factor System in Visceral Adiposity

LEWITT, M. S. (2017) · Biochemistry Insights · doi:10.1177/1178626417703995 · Cited by 46 · see citing works

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification

Wiede, F., Dudakov, J. A., Lu, K., Dodd, G. T., Butt, T., Godfrey, D. I., Strasser, A., Boyd, R. L., & Tiganis, T. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161903 · Cited by 43 · see citing works

Upregulated PTPN2 induced by inflammatory response or oxidative stress stimulates the progression of thyroid cancer

Zhang, Z., Xu, T., Qin, W., Huang, B., Chen, W., Li, S., & Li, J. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.047 · Cited by 45 · see citing works

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Merry, T. L., Tran, M., Dodd, G. T., Mangiafico, S. P., Wiede, F., Kaur, S., McLean, C., Andrikopoulos, S., & Tiganis, T. (2016) · Diabetologia · doi:10.1007/s00125-016-4084-3 · Cited by 43 · see citing works

A Tale of Two Complications of Obesity: NASH and Hepatocellular Carcinoma

Dhanasekaran, R., & Felsher, D. W. (2019) · Hepatology · doi:10.1002/hep.30649 · Cited by 43 · see citing works

Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice

Yao, Z., Gong, Y., Chen, W., Shao, S., Song, Y., Guo, H., Li, Q., Liu, S., Wang, X., Zhang, Z., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00896-7 · Cited by 43 · see citing works

High‐fat diet in a mouse insulin‐resistant model induces widespread rewiring of the phosphotyrosine signaling network

Dittmann, A., Kennedy, N. J., Soltero, N. L., Morshed, N., Mana, M., Yilmaz, Ö. H., Davis, R. J., & White, F. M. (2019) · Molecular Systems Biology · doi:10.15252/msb.20198849 · Cited by 34 · see citing works

Type I interferons as key players in pancreatic β-cell dysfunction in type 1 diabetes

Marroquí, L., Perez-Serna, A. A., Babiloni-Chust, I., & dos Santos, R. S. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.02.011 · Cited by 37 · see citing works

Zinc, selenium and chromium co-supplementation improves insulin resistance by preventing hepatic endoplasmic reticulum stress in diet-induced gestational diabetes rats

Yao, X., Liu, R., Li, X., Yan, L., Zhang, Z., Huang, S., Ge, Y., Chen, X., & Yang, X. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108810 · Cited by 37 · see citing works

Role of NLRP3 inflammasome and oxidative stress in hepatic insulin resistance and the ameliorative effect of phytochemical intervention

de Deus, I. J., Martins-Silva, A. F., Fagundes, M. M. D. A., Paula-Gomes, S., Silva, F. G. D. E., da Cruz, L. L., de Abreu, A. R. R., & de Queiroz, K. B. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1188829 · Cited by 34 · see citing works

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice

Yin, W., Xu, H., Bai, Z., Wu, Y., Zhang, Y., Liu, R., Wang, Z., Zhang, B., Shen, J., Zhang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-55939-2 · Cited by 34 · see citing works

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity

Gilglioni, E. H., Li, A., St‐Pierre‐Wijckmans, W., Shen, T.-K., Pérez-Chávez, I., Hovhannisyan, G., Lisjak, M., Negueruela, J., Vandenbempt, V., Bauzá‐Martinez, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53733-0 · Cited by 32 · see citing works

PTPN2 improved renal injury and fibrosis by suppressing STAT‐induced inflammation in early diabetic nephropathy

Li, Y., Zhou, H., Li, Y., Han, L., Song, M., Chen, F., Shang, G., Wang, D., Wang, Z., Zhang, W., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14304 · Cited by 31 · see citing works

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

Elvira, B., Vandenbempt, V., Bauzá‐Martinez, J., Crutzen, R., Negueruela, J., Ibrahim, H., Winder, M. L., Brahma, M. K., Vekeriotaite, B., Martens, P.-J., et al. (2022) · Diabetes · doi:10.2337/db21-0443 · Cited by 31 · see citing works

Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling

Duval, R., Bui, L. C., Mathieu, C., Nian, Q., Berthelet, J., Xu, X., Haddad, I., Vinh, J., Dupret, J., Busi, F., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008666 · Cited by 30 · see citing works

Effect of N-acetyl-l-cysteine on insulin resistance caused by prolonged free fatty acid elevation

Pereira, S., Shah, A., Fantus, I. G., Joseph, J. W., & Giacca, A. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0676 · Cited by 29 · see citing works

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity

Litwak, S. A., Pang, L., Galić, S., Igoillo‐Esteve, M., Stanley, W. J., Turatsinze, J., Loh, K., Thomas, H. E., Sharma, A., Trépo, E., et al. (2017) · Diabetes · doi:10.2337/db17-0348 · Cited by 29 · see citing works

The oncogenic mechanisms of the Janus kinase-signal transducer and activator of transcription pathway in digestive tract tumors

Zhao, R., Hu, Z., Zhang, X., Huang, S., Yu, G., Wu, Z. B., Yu, W., Lu, J., & Ruan, B. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01421-9 · Cited by 29 · see citing works

Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice

Wali, J. A., Galić, S., Tan, C. Y. R., Gurzov, E. N., Frazier, A. E., Connor, T., Ge, J., Pappas, E. G., Stroud, D. A., Varanasi, L., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.168 · Cited by 26 · see citing works

Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice

Hsu, M.-F., Koike, S., Mello, A., Nagy, L. E., & Haj, F. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101658 · Cited by 25 · see citing works

Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice

Xi, Y., Liu, S., Bettaieb, A., Matsuo, K., Matsuo, I., Hosein, E., Chahed, S. L., Wiede, F., Zhang, S., Zhang, Z., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3413-7 · Cited by 23 · see citing works

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

Stanley, W. J., Litwak, S. A., Quah, H. S., Tan, S. M., Kay, T. W. H., Tiganis, T., de Haan, J. B., Thomas, H. E., & Gurzov, E. N. (2015) · Diabetes · doi:10.2337/db14-1575 · Cited by 22 · see citing works

Anti-diabetic effect of Alpinia oxyphylla extract on 57BL/KsJ db-/db- mice

Xie, Y., Xiao, M., Li, D., Liu, H., Yun, F., Yi, W., Sang, S., & Du, G. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4152 · Cited by 22 · see citing works

Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases

Tiganis, T., & Tonks, N. K. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00882-9 · Cited by 22 · see citing works

STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity

Schaschkow, A., Pang, L., Vandenbempt, V., Elvira, B., Litwak, S. A., Vekeriotaite, B., Maillard, É., Vermeersch, M., de Paula, F. M. M., Pinget, M., et al. (2021) · Diabetes · doi:10.2337/db20-1222 · Cited by 21 · see citing works

MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes

Zhang, Y., Hui, J., Xu, Y., Ma, Y., Sun, Z., Zhang, M., Nie, L., & Ye, L. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133925 · Cited by 21 · see citing works

Zinc oxide nanoparticles characterization and therapeutic evaluation on high fat / sucrose diet induced-obesity

El‐Seidy, A. M. A., Bashandy, S. A. E., Ibrahim, F., El-Rahman, S. A., Ahmed-Farid, O. A.-H., Moussa, S. A. A., & Elbaset, M. A. (2022) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2022.112166.5113 · Cited by 19 · see citing works

Endocrine, Genetic, and Microbiome Nexus of Obesity and Potential Role of Postbiotics: A Narrative Review

Wu, W., Chen, Z., Han, J., Qian, L., Wang, W., Lei, J., & Wang, H. (2023) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/s40519-023-01593-w · Cited by 18 · see citing works

Zinc Supplementation and Strength Exercise in Rats with Type 2 Diabetes: Akt and PTP1B Phosphorylation in Nonalcoholic Fatty Liver

Vivero, A., Manuel Ruz, O., Rivera, M., Miranda, K., Sacristán, C., Espinosa, A., Codoceo, J., Inostroza, J., Vásquez, K. Y., Pérez, Á., et al. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02324-3 · Cited by 18 · see citing works

A Narrative Review of Diabetic Macroangiopathy: From Molecular Mechanism to Therapeutic Approaches

Yin, J., Fu, X., Luo, Y., Leng, Y., Ao, L., & Xie, C. (2024) · Diabetes Therapy · doi:10.1007/s13300-024-01532-7 · Cited by 25 · see citing works

Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity

Zhou, S., Yu, D., Ning, S., Zhang, H., Jiang, L., He, L., Li, M., & Sun, M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000374019 · Cited by 18 · see citing works

Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2

Hamel-Côté, G., Lapointe, F., Véronneau, S., Mayhue, M., Rola‐Pleszczynski, M., & Staňková, J. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0316-9 · Cited by 18 · see citing works

IL-15 and N-803 for HIV Cure Approaches

Howard, J. N., & Bosque, A. (2023) · Viruses · doi:10.3390/v15091912 · Cited by 16 · see citing works

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration

Wu, W., Hale, A. J., Lemeer, S., & den Hertog, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-07109-8 · Cited by 17 · see citing works

Inflammation in glomerular diseases

Xiong, Y., Li, W., Jin, S., Wan, S., & Wu, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526285 · Cited by 18 · see citing works

The water extract of Potentilla discolor Bunge (PDW) ameliorates high-sugar diet-induced type II diabetes model in Drosophila melanogaster via JAK/STAT signaling

Li, Y., Wang, J., Xu, Y., Meng, Q., Su, Y., Su, Y., Miao, Y., & Wang, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116760 · Cited by 17 · see citing works

OP449 inhibits breast cancer growth without adverse metabolic effects

Shlomai, G., Zelenko, Z., Antoniou, I. M., Stasinopoulos, M., Tobin‐Hess, A., Vitek, M. P., LeRoith, D., & Gallagher, E. J. (2017) · Endocrine Related Cancer · doi:10.1530/erc-17-0077 · Cited by 16 · see citing works

Metabolism-programming mRNA-lipid nanoparticles remodel the immune microenvironment to improve immunotherapy against MAFLD.

Yu, X.-Y., Qi, S.-L., Cao, W.-Y., Cheng, M.-Q., Zhang, W.-J., Wang, Y.-F., Zheng, R.-J., Jin, G.-W., Gao, X.-M., Lu, M., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adv2293 · Cited by 16 · see citing works

Sex Differences in Glutathione Peroxidase Activity and Central Obesity in Patients with Type 2 Diabetes at High Risk of Cardio-Renal Disease

Steyn, M., Zitouni, K., Kelly, F. J., Cook, P. R., & Earle, K. (2019) · Antioxidants · doi:10.3390/antiox8120629 · Cited by 15 · see citing works

Selective Effects of Cold Atmospheric Plasma on Bone Sarcoma Cells and Human Osteoblasts

Nitsch, A., Sieb, K. F., Qarqash, S., Schoon, J., Ekkernkamp, A., Wassilew, G. I., Niethard, M., & Haralambiev, L. (2023) · Biomedicines · doi:10.3390/biomedicines11020601 · Cited by 15 · see citing works

Insights on post-translational modifications in fatty liver and fibrosis progression

Raju, C. N., & Sankaranarayanan, K. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167659 · Cited by 15 · see citing works

Potent and selective PTP1B inhibition by a platinum( ii ) complex: possible implications for a new antitumor strategy

Yuan, C., Wang, W., Wang, J., Li, X., Wu, Y., Li, S., Lu, L., Zhu, M., Xing, S., & Fu, X. (2019) · Chemical Communications · doi:10.1039/c9cc06972k · Cited by 15 · see citing works

Mechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomics and gut microbiome

Sun, C., Lan, F., Zhou, Q., Guo, X., Jin, J., Wen, C., Guo, Y., Hou, Z., Zheng, J., Wu, G., et al. (2024) · GigaScience · doi:10.1093/gigascience/giae023 · Cited by 14 · see citing works

Regulation of protein phosphorylation by PTPN2 and its small-molecule inhibitors/degraders as a potential disease treatment strategy

Wang, D., Wang, W., Song, M., Xie, Y., Kuang, W., & Yang, P. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116774 · Cited by 14 · see citing works

In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K., Tun, X., & Utsumi, H. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7336 · Cited by 14 · see citing works

Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 signalling pathway

Zhang, X., Zhuang, Y., Qin, T., Chang, M., Ji, X., Wang, N., Zhang, Z., Zhou, H., Wang, Q., & Li, J. Z. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154823 · Cited by 14 · see citing works

PCBP2 regulates hepatic insulin sensitivity via HIF-1α and STAT3 pathway in HepG2 cells

Xia, N., Tang, Z., Wang, C., Xu, G., Nie, X., Zhang, W., Zhao, Y., Wang, S., Zhu, X., & Cui, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.150 · Cited by 13 · see citing works

Genetic susceptibility of increased intestinal permeability is associated with progressive liver disease and diabetes in patients with non-alcoholic fatty liver disease

Miele, L., Giorgio, V., Liguori, A., Petta, S., Pastorino, R., Arzani, D., Alberelli, M. A., Cefalo, C., Marrone, G., Biolato, M., et al. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.06.013 · Cited by 13 · see citing works

T Cell Protein Tyrosine Phosphatase in Osteoimmunology

Wang, Y., Liu, S., Jia, T., Feng, Y., Zhang, W., Xu, X., & Zhang, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620333 · Cited by 12 · see citing works

The Role of Oxidative Inactivation of Phosphatase PTEN and TCPTP in Fatty Liver Disease

Huu, T. N., Park, J., Zhang, Y., Thanh, H. D., Park, I., Choi, J. M., Yoon, H. J., Park, S. C., Woo, H. A., & Lee, S.-R. (2023) · Antioxidants · doi:10.3390/antiox12010120 · Cited by 12 · see citing works

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Wang, Y., Liu, S., Jia, T., Feng, Y., Xu, X., & Zhang, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.682947 · Cited by 10 · see citing works

Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and atherosclerosis

Mo, S., Wang, Y., Yuan, X., Wu, W.-H., Zhao, H., Wei, H., Qin, H., Jiang, H., & Qin, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1142296 · Cited by 9 · see citing works

Association of metabolic syndrome components with alterations in oxidative stress and cytokines expression

Abdelazeem, A. H., Abuelsaad, A. S. A., Abdel‐Moneim, A., & Abdel‐Gabbar, M. (2021) · Journal of Taibah University for Science · doi:10.1080/16583655.2021.2009680 · Cited by 9 · see citing works

Metabolic dysfunction-associated steatohepatitis reduces hepatic H2S-producing enzymes altering persulfidome composition

Shen, T. K., Vignane, T., Gilglioni, E. H., Traini, L., Kalaitsidou, E., Conan, P., Li, A., St‐Pierre‐Wijckmans, W., Herranz, J. M., Elvira, B., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103809 · Cited by 8 · see citing works

Protein tyrosine phosphatase nonreceptor type 2 exerts antimetastatic functions in pancreatic ductal adenocarcinoma

Zhang, S., Wang, H., Mao, P., Sun, Q., Su, H., Zhang, Y., Shen, S., Xu, G., Wang, L., Zou, X., et al. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23554 · Cited by 8 · see citing works

p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

Litwak, S. A., Loh, K., Stanley, W. J., Pappas, E. G., Wali, J. A., Selck, C., Strasser, A., Thomas, H. E., & Gurzov, E. N. (2016) · Scientific Reports · doi:10.1038/srep23802 · Cited by 8 · see citing works

Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa

Bellomo, C., Furone, F., Rotondo, R., Ciscognetti, I., Carpinelli, M., Nicoletti, M., D’Aniello, G., Sepe, L., Barone, M. V., & Nanayakkara, M. (2024) · Cells · doi:10.3390/cells13231981 · Cited by 7 · see citing works

Advancing the Metabolic Dysfunction-Associated Steatotic Liver Disease Proteome: A Post-Translational Outlook

Chowdhury, K., Das, D., & Huang, M. (2025) · Genes · doi:10.3390/genes16030334 · Cited by 7 · see citing works

Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

Wang, A., Zhang, Y., Lv, X., & Liang, G. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.006 · Cited by 7 · see citing works

SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis

Kumar, A., Schwab, M. G., Labrada, B. L., Silveira, M. A. D., Goudreault, M., Fournier, É., Bellmann, K., Beauchemin, N., Gingras, A., Bilodeau, S., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105164 · Cited by 7 · see citing works

Insulin Resistance in Obesity

Qi, Y., Guo, X., & Guo, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_28 · Cited by 7 · see citing works

How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?

Asim, F., Clarke, L., Donnelly, E., Jamal, F. R., Piccicacchi, L. M., Qadir, M., Raja, N. T., Samadi, C., Then, C. K., & Kiltie, A. E. (2023) · BMJ Oncology · doi:10.1136/bmjonc-2023-000107 · Cited by 5 · see citing works

Biomarkers of growth and carbohydrate metabolism in neonatal rats supplemented with fish oil and/or antioxidants during intermittent hypoxia

Galetaki, D. M., Cai, C. L., Bhatia, K., Chin, V. L., Aranda, J. V., & Beharry, K. D. A. (2022) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2022.101513 · Cited by 5 · see citing works

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunityPreprint

Liang, S., Tran, E., Du, X., Dong, J., Sudholz, H., Chen, H., Qu, Z., Huntington, N. D., Babon, J. J., Kershaw, N. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.16.545220 · Cited by 5 · see citing works

Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis

Meng, H., Li, J., Yang, Y., Zheng, Y., Wang, S., Guo, X., Du, L., & Wu, H. (2024) · Journal of Oleo Science · doi:10.5650/jos.ess24055 · Cited by 4 · see citing works

S‐9‐PAHSA's neuroprotective effect mediated by CAIII suppresses apoptosis and oxidative stress in a mouse model of type 2 diabetes

Wang, J.-T., Wang, X.-R., Ren, J.-Q., Lin, J.-H., Yu, Z., Huang, S.-S., Hu, Y., Fu, J.-Y., Wang, M., Zhang, Y., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14594 · Cited by 4 · see citing works

A crucial role of adenosine deaminase in regulating gluconeogenesis in mice

Ding, Z., Ge, W., Xu, X., Xu, X., Sun, Q., Xu, X., & Zhang, J. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107425 · Cited by 4 · see citing works

Characterization of novel dual PTPN1 and PTPN2 inhibitorsPreprint

Bosque, A., Howard, J. N., Zaikos, T. D., Levinger, C., Rivera, E., McMahon, E. K., Sanz, M., Copertino, D. C., Wang, W., Soriano-Sarabia, N., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2869323/v1 · Cited by 4 · see citing works

Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice

Brahma, M. K., Xiao, P., Popa, M. O., Negueruela, J., Vandenbempt, V., Demine, S., Cardozo, A. K., & Gurzov, E. N. (2022) · Nutrients · doi:10.3390/nu14183866 · Cited by 3 · see citing works

Targeting Protein Phosphatases for the Treatment of Chronic Liver Disease

Li, Y., He, H., & Zhang, N. (2024) · Current Drug Targets · doi:10.2174/0113894501278886231221092522 · Cited by 2 · see citing works

STAT Signature Dish: Serving Immunity with a Side of Dietary Control

Metwally, H. (2025) · Biomolecules · doi:10.3390/biom15040487 · Cited by 2 · see citing works

Dissociating nonalcoholic steatohepatitis from hepatocellular carcinoma in obesity

Pοlyzos, S. A., Kountouras, J., Goulas, A., Papakonstantinou, E., & Papaioannidou, P. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.07.18 · Cited by 2 · see citing works

Renoprotective effect of polyphenolic-rich extract of Phyllanthus niruri in streptozotocin-induced diabetic nephropathy via moderation of oxidative stress and inhibition of kidney injury

Afolabi, O. B., Akinola, A. G., Raji, A. K., Obafemi, T. O., Olasehinde, O. R., Olorunlagba, A. O., Babatunde, O. J., Obafemi, B. A., Omotuyi, O. I., Oloyede, O. I., et al. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10667-1 · Cited by 1 · see citing works

Anti-diabetic Effect of Opuntia humifusa Extracts in Diabetic db/db Mice

Park, Y. M., Lee, H. Y., Shin, D. Y., Kim, K. H., Yoo, K. H., Yoo, S., Yoo, S., & Kim, J. G. (2024) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2024.32.4.234 · Cited by 1 · see citing works

Insulin Resistance in Obesity

Qi, Y., Guo, X., & Guo, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_28-1 · Cited by 1 · see citing works

A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes.

Lin, Q. (2018) · doi:10.18297/etd/3016

Protein tyrosine phosphatase receptor kappa regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesityPreprint

Gilglioni, E. H., Li, A., St‐Pierre‐Wijckmans, W., Shen, T.-K., Pérez-Chávez, I., Hovhannisyan, G., Lisjak, M., Negueruela, J., Vandenbempt, V., Bauzá‐Martinez, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.01.569004 · Cited by 1 · see citing works

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Merry, T. L., Tran, M., Stathopoulos, M., Wiede, F., Fam, B. C., Dodd, G. T., Clarke, I. J., Watt, M. J., Andrikopoulos, S., & Tiganis, T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5428 · Cited by 69 · see citing works

Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity

Li, Z., Lai, Z. W., Christiano, R., Gazos‐Lopes, F., Walther, T. C., & Farese, R. V. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000560 · Cited by 22 · see citing works

Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling

González‐Rodríguez, Á., & Valverde, Á. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7855-3_6

Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance

Xu, E., Charbonneau, A., Rolland, Y., Bellmann, K., Pao, L. I., Siminovitch, K. A., Neel, B. G., Beauchemin, N., & Marette, A. (2012) · Diabetes · doi:10.2337/db11-1502 · Cited by 41 · see citing works

Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects

Rametta, R., Mozzi, E., Dongiovanni, P., Motta, B. M., Milano, M., Roviaro, G., Fargion, S. R., & Valenti, L. V. C. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.181 · Cited by 43 · see citing works