Reactive oxygen species and insulin resistance: the good, the bad and the ugly
Abstract
Reactive oxygen species (ROS) contribute to the progression of various human diseases, including type 2 diabetes mellitus (T2DM). ROS can suppress the insulin response and contribute to the development of insulin resistance, a key pathological feature of T2DM. Paradoxically, ROS generated by NADP(H) oxidases at the plasma membrane and endomembranes might also be required for normal intracellular signaling. Growth factors, cytokines and hormones such as insulin promote the generation of ROS for the coordinated inactivation of protein tyrosine phosphatases and the promotion of tyrosine phosphorylation-dependent signaling. A recent study has established the potential of H(2)O(2) to enhance insulin sensitivity in vivo and attenuate the development of insulin resistance. Thus, ROS have the capacity to both promote and attenuate the insulin response. Here I review evidence indicating that ROS promote insulin sensitivity versus insulin resistance and discuss the potential complications associated with the widespread use of antioxidants.
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The increase in lipid peroxidation in Mck-Cre;Nox4fl/fl mice approximated that seen in high fat-fed obese mice.
“the increase in lipid peroxidation approximated that seen in high fat–fed obese mice (fig. S9E) that are characterized by systemic oxidative stress (13, 17).”
From Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance (2021) · cites this paper as [17]
Oxidative stress and consequent oxidative damage have the potential to drive insulin resistance.
“Given the well-established potential for oxidative stress and consequent oxidative damage to drive insulin resistance (11–18), we reasoned that the development of insulin resistance in the sedentary aged mice may be attributed to decreased NOX4 abundance or activity.”
From Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance (2021) · cites this paper as [17]
Obesity is associated with systemic oxidative stress, which promotes insulin resistance.
“Obesity is associated with systemic oxidative stress (43, 44), which promotes insulin resistance (11–18).”
From Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance (2021) · cites this paper as [17]
Cites
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413 · see citing works
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275 · see citing works
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
H <sub>2</sub> O <sub>2</sub> , a Necessary Evil for Cell Signaling
Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160 · see citing works
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,120 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773 · see citing works
Protein tyrosine phosphatases: from genes, to function, to disease
Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,685 · see citing works
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604 · see citing works
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Regulation of JNK signaling by GSTp
Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1321 · Cited by 1,105 · see citing works
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
Meng, T.-C., Fukada, T., & Tonks, N. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00445-8 · Cited by 1,040 · see citing works
Lee, S.-R., Kwon, K.-S., Kim, S.-R., & Rhee, S. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15366 · Cited by 969 · see citing works
Schulze‐Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., & Fiers, W. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42768-8 · Cited by 935 · see citing works
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · see citing works
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887 · see citing works
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Ozcan, L., Ergin, A. S., Lu, A., Chung, J., Sarkar, S., Nie, D., Myers, M. G., & Ozcan, U. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.004 · Cited by 875 · see citing works
Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works
The Burden of Mortality Attributable to Diabetes
Roglić, G., Unwin, N. C., Bennett, P. H., Mathers, C. D., Tuomilehto, J. O., Nag, S., Connolly, V. M., & King, H. O. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2130 · Cited by 809 · see citing works
Tripathy, D., Mohanty, P., Dhindsa, S., Syed, T., Ghanim, H., Aljada, A., & Dandona, P. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2882 · Cited by 658 · see citing works
Kwon, J., Lee, S.-R., Yang, K.-S., Ahn, Y., Kim, Y. J., Stadtman, E. R., & Rhee, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407396101 · Cited by 631 · see citing works
Plomgaard, P., Bouzakri, K., Krogh-Madsen, R., Mittendorfer, B., Zierath, J. R., & Pedersen, B. K. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2939 · Cited by 627 · see citing works
Glucose Challenge Stimulates Reactive Oxygen Species (ROS) Generation by Leucocytes
Mohanty, P., Hamouda, W., Garg, R., Aljada, A., Ghanim, H., & Dandona, P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6854 · Cited by 621 · see citing works
Woo, H. A., Yim, S. H., Shin, D. H., Kang, D., Yu, D., & Rhee, S. G. (2010) · Cell · doi:10.1016/j.cell.2010.01.009 · Cited by 613 · see citing works
Reactive oxygen species enhance insulin sensitivity
Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.009 · Cited by 581 · see citing works
Self-citationLiu, H., Nishitoh, H., Ichijo, H., & Kyriakis, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2198-2208.2000 · Cited by 545 · see citing works
Insulin resistance is a cellular antioxidant defense mechanism
Hoehn, K. L., Salmon, A. B., Hohnen-Behrens, C., Turner, N., Hoy, A. J., Maghzal, G. J., Stocker, R., Van Remmen, H., Kraegen, E. W., Cooney, G. J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902380106 · Cited by 540 · see citing works
Kim, Y., Morgan, M. J., Choksi, S., & Liu, Z.-G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.021 · Cited by 517 · see citing works
Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., & Goldstein, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1844-1854.2004 · Cited by 513 · see citing works
Mahadev, K., Zilbering, A., Zhu, L., & Goldstein, B. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100109200 · Cited by 509 · see citing works
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Chen, K., Kirber, M. T., Xiao, H. Q., Yang, Y., & Keaney, J. F. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709049 · Cited by 468 · see citing works
Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men
Urakawa, H., Katsuki, A., Sumida, Y., Gabazza, E. C., Murashima, S., Morioka, K., Maruyama, N., Kitagawa, N., Tanaka, T., Hori, Y., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030202 · Cited by 416 · see citing works
Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works
Dandona, P., Mohanty, P., Ghanim, H., Aljada, A., Browne, R. W., Hamouda, W., Prabhala, A., Afzal, A., & Garg, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7150 · Cited by 370 · see citing works
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337 · see citing works
Protein kinase D mediates a stress‐induced NF‐κB activation and survival pathway
Störz, P., & Toker, A. (2002) · The EMBO Journal · doi:10.1093/emboj/cdg009 · Cited by 325 · see citing works
Foxo1 integrates insulin signaling with mitochondrial function in the liver
Cheng, Z., Guo, S., Copps, K., Dong, X., Kollipara, R., Rodgers, J. T., Depinho, R. A., Puigserver, P., & White, M. F. (2009) · Nature Medicine · doi:10.1038/nm.2049 · Cited by 321 · see citing works
IRS1-Independent Defects Define Major Nodes of Insulin Resistance
Hoehn, K. L., Hohnen-Behrens, C., Cederberg, A., Wu, L. E., Turner, N. A., Yuasa, T., Ebina, Y., & James, D. E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.005 · Cited by 321 · see citing works
Dang, P. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27544 · Cited by 319 · see citing works
Protein tyrosine phosphatase function: the substrate perspective
Tiganis, T., & Bennett, A. M. (2007) · Biochemical Journal · doi:10.1042/bj20061548 · Cited by 299 · see citing works
Self-citationMeng, T., Buckley, D. A., Galić, S., Tiganis, T., & Tonks, N. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404606200 · Cited by 276 · see citing works
Self-citationOmenn, G. S., Goodman, G. E., Thornquist, M. D., Grizzle, J. E., Rosenstock, L., Barnhart, S., Balmes, J. R., Cherniack, M. G., Cullen, M. R., & Glass, A. G. (1994) · PubMed · Cited by 256 · see citing works
Disulfide Formation in the ER and Mitochondria: Two Solutions to a Common Process
Riemer, J., Bulleid, N. J., & Herrmann, J. M. (2009) · Science · doi:10.1126/science.1170653 · Cited by 250 · see citing works
Mohanty, P., Ghanim, H., Hamouda, W., Aljada, A., Garg, R., & Dandona, P. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.4.767 · Cited by 239 · see citing works
Use of Dietary Supplements for Weight Loss in the United States: Results of a National Survey
Pillitteri, J. L., Shiffman, S. M., Rohay, J. M., Harkins, A. M., Burton, S. L., & Wadden, T. A. (2008) · Obesity · doi:10.1038/oby.2007.136 · Cited by 237 · see citing works
Haber, C. A., Lam, T. K. T., Yu, Z., Gupta, N., Goh, T. T., Bogdanovic, E., Giacca, A., & Fantus, I. G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00355.2002 · Cited by 225 · see citing works
Millen, A. E., Dodd, K. W., & Subar, A. F. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.03.022 · Cited by 217 · see citing works
NADPH oxidases: New kids on the block
Geiszt, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.05.004 · Cited by 214 · see citing works
Paquot, N., Castillo, M. J., Lefèbvre, P. J., & Scheen, A. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6417 · Cited by 213 · see citing works
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Jang, Y. C., Pérez, V., Song, W. J., Lustgarten, M. S., Salmon, A. B., Mele, J., Qi, W., Liu, Y., Liang, H., Chaudhuri, A. R., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp100 · Cited by 201 · see citing works
Seo, J. H., Ahn, Y., Lee, S.-R., Yeo, C., & Hur, K. C. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0369 · Cited by 175 · see citing works
Dandona, P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.1.355 · Cited by 171 · see citing works
Russell, A. P., Gastaldi, G., Bobbioni-Harsch, E., Arboit, P., Gobelet, C., Dériaz, O., Golay, A., Witztum, J. L., & Giacobino, J.-P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00875-5 · Cited by 166 · see citing works
Song, Y., Cook, N. R., Albert, C. M., Van Denburgh, M., & Manson, J. E. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27491 · Cited by 162 · see citing works
Plomgaard, P., Nielsen, A. R., Fischer, C. P., Mortensen, O. H., Broholm, C., Penkowa, M., Krogh-Madsen, R., Erikstrup, C., Lindegaard, B., Petersen, A. M. W., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0834-6 · Cited by 152 · see citing works
Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A., Dauchet, L., Galan, P., & Herçberg, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.394 · Cited by 150 · see citing works
Loya, A. M., González-Stuart, A., & Rivera, J. O. (2009) · Drugs & Aging · doi:10.2165/00002512-200926050-00006 · Cited by 149 · see citing works
Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial
Liu, S., Lee, I.-M. M., Song, Y., Denburgh, M. V., Cook, N. R., Manson, J. E., & Buring, J. E. (2006) · Diabetes · doi:10.2337/db06-0456 · Cited by 148 · see citing works
Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance
Sabio, G., Kennedy, N. J., Cavanagh, J., Jung, D. Y., Ko, H. J., Ong, H., Barrett, T., Kim, J. K., & Davis, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01162-09 · Cited by 144 · see citing works
Kwon, J., Shatynski, K. E., Chen, H., Morand, S. C., Deken, X. D., Miot, F., Leto, T. L., & Williams, M. S. (2010) · Science Signaling · doi:10.1126/scisignal.2000976 · Cited by 139 · see citing works
Morino, K., Neschen, S., Bilz, S., Sono, S., Tsirigotis, D., Reznick, R. M., Moore, I., Nagai, Y., Samuel, V., Sebastian, D., et al. (2008) · Diabetes · doi:10.2337/db06-0454 · Cited by 125 · see citing works
Redox Regulation of Interleukin-4 Signaling
Sharma, P., Chakraborty, R., Wang, L., Min, B., Tremblay, M. L., Kawahara, T., Lambeth, J. D., & Haque, S. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.019 · Cited by 100 · see citing works
Effect of α-tocopherol and β-carotene supplementation on the incidence of type 2 diabetes
Kataja-Tuomola, M., Sundell, J., Männistö, S., Virtanen, M. J., Kontto, J. P., Albanes, D., & Virtamo, J. R. K. (2007) · Diabetologia · doi:10.1007/s00125-007-0864-0 · Cited by 88 · see citing works
Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A., Dauchet, L., Galan, P., & Herçberg, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.395 · Cited by 82 · see citing works
Storozhevykh, T. P., Senilova, Y. E., Persiyantseva, N. A., Pinelis, V. G., & Pomytkin, I. A. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-84 · Cited by 69 · see citing works
Lamb, M. J. (1977) · Blackie eBooks · Cited by 64 · see citing works
Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK
Berdichevsky, A., Guarente, L., & Bose, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093633 · Cited by 62 · see citing works
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Li, M., Chi, X., Wang, Y., Setrerrahmane, S., Xie, W., & Xu, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01073-0 · Cited by 939 · see citing works
Tebay, L. E., Robertson, H., Durant, S. T., Vitale, S. R., Penning, T. M., Dinkova-Kostova, A. T., & Hayes, J. D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.021 · Cited by 837 · see citing works
Redox regulation of FoxO transcription factors
Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747 · see citing works
Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works
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Finkel, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r111.271999 · Cited by 390 · see citing works
Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.053 · Cited by 373 · see citing works
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Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316 · see citing works
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- Authors
- Tiganis, T.
- Affiliations
- Monash University (AU)
- Corresponding author
- Tiganis, Tony
- ORCID
- Tiganis, Tony
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 32
- Issue
- 2
- Pages
- 82-89
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2033242249
- Cited by
- 256
- References
- 88
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 16 · 2023: 19 · 2022: 14 · 2021: 15 · 2020: 25 · 2019: 14 · 2018: 18 · 2017: 18 · 2016: 24 · 2015: 18 · 2014: 12 · 2013: 20 · 2012: 14
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, insulin resistance, type 2 diabetes, NADPH oxidase, hydrogen peroxide, insulin signaling, protein tyrosine phosphatase, tyrosine phosphorylation, antioxidants, oxidative stress
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Signal Transduction, Reactive Oxygen Species, Disease Progression
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