Brugge, Joan S.
Harvard University
13 papers on CoChatORCID 0000-0002-2547-4814
Most cited papers
- Verified
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics
Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer
Cited by 1,120
- Verified
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature
Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer
Cited by 1,031
- Verified
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell
Cancer-related Molecular PathwaysCell Adhesion Molecules Research
Cited by 796
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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion
Overholtzer, M., Mailleux, A. A., Mouneimne, G., Normand, G., Schnitt, S. J., King, R. W., Cibas, E. S., & Brugge, J. S. (2007) · Cell
Cell death mechanisms and regulationCellular Mechanics and Interactions
Cited by 748
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Ovarian Cancer Spheroids Use Myosin-Generated Force to Clear the Mesothelium
Iwanicki, M. P., Davidowitz, R. A., Ng, M. R., Besser, A., Muranen, T., Merritt, M., Danuser, G., Ince, T., & Brugge, J. S. (2011) · Cancer Discovery
Cellular Mechanics and InteractionsCancer Cells and Metastasis
Cited by 303
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Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells
Coloff, J. L., Murphy, J. P., Braun, C. R., Harris, I. S., Shelton, L. M., Kami, K., Gygi, S. P., Selfors, L. M., & Brugge, J. S. (2016) · Cell Metabolism
Amino Acid Enzymes and MetabolismCancer, Hypoxia, and Metabolism
Cited by 288
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BIM Regulates Apoptosis during Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms
Mailleux, A. A., Overholtzer, M., Schmelzle, T., Bouillet, P., Strasser, A., & Brugge, J. S. (2007) · Developmental Cell
Cell death mechanisms and regulationDevelopmental Biology and Gene Regulation
Cited by 255
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Vav family GEFs link activated ephs to endocytosis and axon guidance
Cowan, C. W., Shao, Y. R., Sahin, M., Shamah, S. M., Lin, M. Z., Greer, P. L., Gao, S., Griffith, E. C., Brugge, J. S., & Greenberg, M. E. (2005) · Neuron
Axon Guidance and Neuronal SignalingDevelopmental Biology and Gene Regulation
Cited by 246
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A non-genetic route to aneuploidy in human cancers
Krajcovic, M., Johnson, N. B., Sun, Q., Normand, G., Hoover, N., Yao, E., Richardson, A. L., King, R. W., Cibas, E. S., Schnitt, S. J., et al. (2011) · Nature Cell Biology
Microtubule and mitosis dynamicsCellular Mechanics and Interactions
Cited by 188
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Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports
Single-cell and spatial transcriptomicsBreast Cancer Treatment Studies
Cited by 184
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Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics
Liu, J. F., Palakurthi, S., Zeng, Q., Zhou, S., Ivanova, E., Huang, W., Zervantonakis, I. K., Selfors, L. M., Shen, Y., Pritchard, C. C., et al. (2017) · Clinical Cancer Research
Ovarian cancer diagnosis and treatmentBRCA gene mutations in cancer
Cited by 127
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Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
Hung, Y. P., Teragawa, C., Kosaisawe, N., Gillies, T. E., Pargett, M., Minguet, M., Distor, K., Rocha-Gregg, B. L., Coloff, J. L., Keibler, M. A., et al. (2017) · eLife
Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism
Cited by 74
- Verified
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations
Williams, M. J., Oliphant, M. U. J., Au, V., Liu, C., Baril, C., O’Flanagan, C., Lai, D., Beatty, S., Van Vliet, M., Yiu, J. C., et al. (2024) · Nature Genetics
Cancer Genomics and DiagnosticsBRCA gene mutations in cancer
Cited by 34
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