Kosako, Hidetaka

Ubiquitin is phosphorylated by PINK1 to activate parkin

Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., et al. (2014) · Nature

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,477

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., & Matsuda, N. (2013) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 209

Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2

Harita, Y., Kurihara, H., Kosako, H., Tezuka, T., Sekine, T., Igarashi, T., & Hattori, S. (2008) · Journal of Biological Chemistry

Renal Diseases and GlomerulopathiesProtein Kinase Regulation and GTPase Signaling

Cited by 81

Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation

Yamanaka, S., Furihata, H., Yanagihara, Y., Taya, A., Nagasaka, T., Usui, M., Nagaoka, K., Shoya, Y., Nishino, K., Yoshida, S., et al. (2023) · Nature Communications

Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments

Cited by 73

Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding

Yamada, K., Shioya, R., Nishino, K., Furihata, H., Hijikata, A., Kaneko, M. K., Kato, Y., Shirai, T., Kosako, H., & Sawasaki, T. (2023) · Nature Communications

Biotin and Related StudiesHER2/EGFR in Cancer Research

Cited by 18

PITHD1 is a proteasome-interacting protein essential for male fertilization

Kondo, H., Matsumura, T., Kaneko, M., Inoue, K., Kosako, H., Ikawa, M., Takahama, Y., & Ohigashi, I. (2020) · Journal of Biological Chemistry

Sperm and Testicular FunctionUbiquitin and proteasome pathways

Cited by 17

OMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity

Nishigori, M., Hirata, S., Kosako, H., Nolte, H., Riemer, J., Langer, T., & Koshiba, T. (2025) · The EMBO Journal

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 2