Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
Open accessAbstract
PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinase, whereas Parkin functions as an E3 ubiquitin ligase. Under steady-state conditions, Parkin localizes to the cytoplasm where its E3 activity is repressed. A decrease in mitochondrial membrane potential triggers Parkin E3 activity and recruits it to depolarized mitochondria for ubiquitylation of mitochondrial substrates. The molecular basis for how the E3 activity of Parkin is re-established by mitochondrial damage has yet to be determined. Here we provide in vitro biochemical evidence for ubiquitin-thioester formation on Cys-431 of recombinant Parkin. We also report that Parkin forms a ubiquitin-ester following a decrease in mitochondrial membrane potential in cells, and that this event is essential for substrate ubiquitylation. Importantly, the Parkin RING2 domain acts as a transthiolation or acyl-transferring domain rather than an E2-recruiting domain. Furthermore, formation of the ubiquitin-ester depends on PINK1 phosphorylation of Parkin Ser-65. A phosphorylation-deficient mutation completely inhibited formation of the Parkin ubiquitin-ester intermediate, whereas phosphorylation mimics, such as Ser to Glu substitution, enabled partial formation of the intermediate irrespective of Ser-65 phosphorylation. We propose that PINK1-dependent phosphorylation of Parkin leads to the ubiquitin-ester transfer reaction of the RING2 domain, and that this is an essential step in Parkin activation. Background: Parkin is a ubiquitin ligase activated by a decrease in the mitochondrial membrane potential (ΔΨm). However, details regarding its mechanism remain limited. Results: PINK1-dependent phosphorylation of Parkin at Ser-65 following dissipation of ΔΨm triggers ubiquitin-ester transfer by the RING2 domain of Parkin to Cys-431. Conclusion: Parkin catalyzes trans- (ubiquitin-thioester)ification upon PINK1-dependent phosphorylation. Significance: The molecular process of Parkin-catalyzed ubiquitylation has been determined.
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Phosphorylation of ubiquitin and PRKN at Ser65 by PINK1 is required for activation of the PINK1-PRKN pathway.
“Both events are required for the activation of the pathway.”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [10]
The paper’s Parkin phosphorylation and ubiquitin-ester formation sections report that PINK1-dependent phosphorylation of Parkin at Ser65 is important for Parkin activation. They do not establish that PINK1 phosphorylation of ubiquitin at Ser65 is also required; the discussion only speculates that other PINK1 substrates may be involved. Page numbers are unavailable in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredUpon mitochondrial depolarization, PINK1 stabilizes on the outer mitochondrial membrane and phosphorylates ubiquitin and PRKN at Ser65.
“Upon mitochondrial depolarization, PINK1 stabilizes on the outer mitochondrial membrane, where it phosphorylates ubiquitin (Ub) and PRKN at Ser65 [5–10].”
From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [10]
The Abstract says PINK1 localizes to mitochondria after escaping membrane-potential-dependent degradation and describes PINK1 phosphorylation of Parkin at Ser-65. The paper discusses ubiquitin attachment to Parkin, but the passages found do not say that PINK1 phosphorylates ubiquitin; that part of the citing sentence is unsupported by this source. (LLM, conf=0.90)
Experimental — accuracy not yet measured
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- Authors
- Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., & Matsuda, N.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- Keio University (JP)
- Tokushima University (JP)
- Tokyo Women's Medical University (JP)
- Corresponding author
- Tanaka, Keiji
- Matsuda, Noriyuki
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 288
- Issue
- 30
- Pages
- 22019-22032
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3724655
- OpenAlex
- W2015758704
- Cited by
- 209
- References
- 75
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 19 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 8 · 2016: 18 · 2015: 36 · 2014: 25 · 2013: 5
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (publishedVersion, cc-by)
- Funders
- Japan Society for the Promotion of Science (23570231, 25860721)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- Parkin, PINK1, mitochondrial membrane potential, mitochondrial depolarization, familial parkinsonism
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Binding Sites, Carbonyl Cyanide m-Chlorophenyl Hydrazone, Cells, Cultured, Cysteine, Embryo, Mammalian, Esters, Fibroblasts, HeLa Cells, Humans, Models, Biological, Phosphorylation, Protein Kinases, Serine, Substrate Specificity, Immunoblotting, Mice, Knockout, Ubiquitin, Ubiquitin-Protein Ligases, Mice, Membrane Potential, Mitochondrial, Ubiquitination, Biocatalysis, HEK293 Cells, Proton Ionophores
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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