Frost, Bess

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 1,252

Prion-like mechanisms in neurodegenerative diseases

Frost, B., & Diamond, M. I. (2010) · Nature Reviews Neuroscience

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 776

Tau promotes neurodegeneration through global chromatin relaxation

Frost, B., Hemberg, M., Lewis, J., & Feany, M. B. (2014) · Nature Neuroscience

Alzheimer's disease research and treatmentsGenomics and Chromatin Dynamics

Cited by 495

Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies

Sun, W., Samimi, H., Gamez, M., Zare, H., & Frost, B. (2018) · Nature Neuroscience

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 300

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

Frost, B., Bardai, F. H., & Feany, M. B. (2016) · Current Biology

Alzheimer's disease research and treatmentsNuclear Structure and Function

Cited by 226

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

Frost, B., Ollesch, J., Wille, H., & Diamond, M. I. (2009) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 224

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceAlzheimer's disease research and treatments

Cited by 169

Connecting the dots between tau dysfunction and neurodegeneration

Frost, B., Götz, J., & Feany, M. B. (2015) · Trends in Cell Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 124

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

Ramirez, P., Zuniga, G., Sun, W., Beckmann, A., Ochoa, E., DeVos, S. L., Hyman, B., Chiu, G., Roy, E. R., Cao, W., et al. (2022) · Progress in Neurobiology

Alzheimer's disease research and treatmentsChromosomal and Genetic Variations

Cited by 79

Alzheimer's disease: An acquired neurodegenerative laminopathy

Frost, B. (2016) · Nucleus

Nuclear Structure and FunctionAlzheimer's disease research and treatments

Cited by 74

Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation

Ochoa, E., Ramirez, P., Gonzalez, E., De Mange, J., Ray, W. J., Bieniek, K. F., & Frost, B. (2023) · Science Advances

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 73

The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders

Frost, B., & Dubnau, J. (2024) · Annual Review of Neuroscience

Chromosomal and Genetic VariationsAmyotrophic Lateral Sclerosis Research

Cited by 45

Awakening the dark side: retrotransposon activation in neurodegenerative disorders

Ochoa Thomas, E., Zuniga, G., Sun, W., & Frost, B. (2020) · Current Opinion in Neurobiology

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 35

m6A-dependent circular RNA formation mediates tau-induced neurotoxicity

Atrian, F., Ramirez, P., De Mange, J., Marquez, M., Gonzalez, E. M., Minaya, M., Karch, C. M., & Frost, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Circular RNAs in diseasesAlzheimer's disease research and treatments

Cited by 7