Sinclair, David A.

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 834

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 820

NAD+ in Brain Aging and Neurodegenerative Disorders

Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineNuclear Receptors and Signaling

Cited by 790

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. (2003) · Nature

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 736

Loss of epigenetic information as a cause of mammalian aging

Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 643

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 592

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., et al. (2008) · PLoS ONE

Sirtuins and Resveratrol in MedicineWnt/β-catenin signaling in development and cancer

Cited by 588

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineDNA Repair Mechanisms

Cited by 575

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience

Sirtuins and Resveratrol in MedicineNeuroscience and Neuropharmacology Research

Cited by 541

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell

Nitric Oxide and Endothelin EffectsSirtuins and Resveratrol in Medicine

Cited by 496

Sirtuin activators and inhibitors: Promises, achievements, and challenges

Dai, H., Sinclair, D. A., Ellis, J. L., & Steegborn, C. (2018) · Pharmacology & Therapeutics

Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors Research

Cited by 463

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 451

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

Sinclair, D. A., Mills, K., & Guarente, L. (1997) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 401

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae

Kennedy, B. K., Gotta, M., Sinclair, D. A., Mills, K., McNabb, D. S., Murthy, M., Pak, S. M., Laroche, T., Gasser, S. M., & Guarente, L. (1997) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 375

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Mitchell, S. J., Bernier, M., Aon, M. A., Cortassa, S., Kim, E. Y., Fang, E. F., Palacios, H. H., Ali, A., Navas-Enamorado, I., Di Francesco, A., et al. (2018) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 338

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

Mills, K. D., Sinclair, D. A., & Guarente, L. (1999) · Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 334

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38

Escande, C., Nin, V., Price, N. L., Capellini, V., Gomes, A. P., Barbosa, M. T., O’Neil, L., White, T. A., Sinclair, D. A., & Chini, E. N. (2013) · Diabetes

Sirtuins and Resveratrol in MedicineNatural Antidiabetic Agents Studies

Cited by 332

The role of nuclear architecture in genomic instability and ageing.

Oberdoerffer, P., & Sinclair, D. A. (2007) · Nature Reviews Molecular Cell Biology

Nuclear Structure and FunctionGenomics and Chromatin Dynamics

Cited by 305

Epigenetic changes during aging and their reprogramming potential

Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 283

The economic value of targeting aging

Scott, A. J., Ellison, M., & Sinclair, D. A. (2021) · Nature Aging

Global Health Care IssuesHealth Systems, Economic Evaluations, Quality of Life

Cited by 267

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Schmeisser, K., Mansfeld, J., Kuhlow, D., Weimer, S., Priebe, S., Heiland, I., Birringer, M., Groth, M., Segref, A., Kanfi, Y., et al. (2013) · Nature Chemical Biology

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 236

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., et al. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

Cited by 182

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Berberine and alkaloids researchSirtuins and Resveratrol in Medicine

Cited by 159

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal

Cholesterol and Lipid MetabolismSirtuins and Resveratrol in Medicine

Cited by 153