Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
Open accessAbstract
Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of AMPK by berberine may be dependent on SIRT1, as SIRT1-knockdown cells blocked AMPK activation and prevented the effect of berberine on diet-induced insulin resistance.
“Notably, the activation of AMPK by berberine may be dependent on SIRT1, as SIRT1-knockdown cells blocked AMPK activation and prevented the effect of berberine on diet-induced insulin resistance [95].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [95]
Berberine supplementation protects from high-fat diet-induced mitochondrial dysfunction and hyperglycemia in skeletal muscle, partially attributed to an increase in mitochondrial biogenesis.
“While the precise mechanisms of berberine needs further exploration, recent reports show that berberine supplementation protects from high-fat diet-induced mitochondrial dysfunction and hyperglycemia in skeletal muscle, partially attributed to an increase in mitochondrial biogenesis [95].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [95]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: Redox Regulation of the AMP-Activated Protein Kinase
Han, Y., Wang, Q., Song, P., Zhu, Y., & Zou, M.-H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015420 · Cited by 71 · see citing works
RetractedMootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Self-citationLagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Haslam, D. W., & James, W. P. T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67483-1 · Cited by 3,757 · see citing works
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Self-citationMitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., et al. (2007) · Nature · doi:10.1038/nature06261 · Cited by 1,707 · see citing works
Self-citationTranscriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
Gerhart‐Hines, Z., Rodgers, J. T., Bare, O., Lerin, C., Kim, S., Mostoslavsky, R., Alt, F. W., Wu, Z., & Puigserver, P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601633 · Cited by 1,294 · see citing works
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols · doi:10.1038/nprot.2006.478 · Cited by 1,188 · see citing works
Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., et al. (2006) · Diabetes · doi:10.2337/db06-0006 · Cited by 1,054 · see citing works
Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
Rolo, A. P., & Palmeira, C. M. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.01.003 · Cited by 1,007 · see citing works
Self-citationUncoupling: new approaches to an old problem of bioenergetics
Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893 · see citing works
SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1
Lan, F., Cacicedo, J. M., Ruderman, N., & Ido, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805711200 · Cited by 825 · see citing works
Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705408104 · Cited by 759 · see citing works
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719 · see citing works
The Citrate Condensing Enzyme of Pigeon Breast Muscle and Moth Flight Muscle.
Srere, P. A., Brazil, H., Gonen, L., & Takahashi, M. T. (1963) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.17s-0129 · Cited by 536 · see citing works
Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes · doi:10.2337/db07-1552 · Cited by 535 · see citing works
Berberine suppresses proinflammatory responses through AMPK activation in macrophages
Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454 · see citing works
The role of AMP‐activated protein kinase in mitochondrial biogenesis
Reznick, R. M., & Shulman, G. I. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109512 · Cited by 371 · see citing works
Brautigan, D. L., Ferguson-Miller, S. M., & Margoliash, E. (1978) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(78)53021-8 · Cited by 352 · see citing works
Obesity-related derangements in metabolic regulation
Muoio, D. M., & Newgard, C. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142512 · Cited by 345 · see citing works
Brusq, J.-M. G., Ancellin, N., Grondin, P., Guillard, R., Martin, S., Saintillan, Y., & Issandou, M. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600020-jlr200 · Cited by 344 · see citing works
Determination of the Activity of Succinate, NADH, Choline, and α‐Glycerophosphate Dehydrogenases
Singer, T. P. (1974) · Methods of biochemical analysis · doi:10.1002/9780470110423.ch3 · Cited by 325 · see citing works
Short Term Effects of Leptin on Hepatic Gluconeogenesis and in Vivo Insulin Action
Rossetti, L., Massillon, D., Barzilai, N., Vuguin, P., Chen, W., Hawkins, M., Wu, J., & Wang, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27758 · Cited by 304 · see citing works
de Kreutzenberg, S. V., Ceolotto, G., Papparella, I., Bortoluzzi, A., Semplicini, A., Man, C. D., Cobelli, C., Fadini, G. P., & Avogaro, A. (2010) · Diabetes · doi:10.2337/db09-1187 · Cited by 299 · see citing works
Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity
Ruderman, N. B., Saha, A. K., & Kraegen, E. W. (2003) · Endocrinology · doi:10.1210/en.2003-0849 · Cited by 266 · see citing works
Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis
Xia, X., Yan, J., Shen, Y., Tang, K., Yin, J., Zhang, Y., Yang, D., Liang, H., Ye, J., & Weng, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016556 · Cited by 262 · see citing works
The role of intramuscular lipid in insulin resistance
Hegarty, B. D., Furler, S. M., Ye, J.-M., Cooney, G. J., & Kraegen, E. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01162.x · Cited by 256 · see citing works
Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK
Cheng, Z., Pang, T., Gu, M., Gao, A., Xie, C., Li, J.-Y., Nan, F., & Li, J. X. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.09.007 · Cited by 240 · see citing works
Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S. S., Lee, M., Oh, G. T., Park, H., Lee, K., Lane, M. D., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90710.2008 · Cited by 239 · see citing works
Role of adiponectin in human skeletal muscle bioenergetics
Civitarese, A. E., Ukropcova, B., Carling, S., Hulver, M., DeFronzo, R. A., Mandarino, L., Ravussin, E., & Smith, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.002 · Cited by 234 · see citing works
Zhou, J., Zhou, S., Tang, J., Zhang, K., Guang, L.-X., Huang, Y., Xu, Y. X., Ying, Y., Zhang, L., & Li, D. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.12.056 · Cited by 208 · see citing works
Heilbronn, L. K., Gan, S. K., Turner, N., Campbell, L. V., & Chisholm, D. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2210 · Cited by 184 · see citing works
Bile Acids Affect Liver Mitochondrial Bioenergetics: Possible Relevance for Cholestasis Therapy
Rolo, A. P. (2000) · Toxicological Sciences · doi:10.1093/toxsci/57.1.177 · Cited by 182 · see citing works
Self-citationPereira, G. C., Branco, A. F., Matos, J. A. C., Pereira, S. L., Parke, D., Perkins, E. L., Serafim, T. L., Sardão, V. A., Santos, M. S., Moreno, A. J. M., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.128017 · Cited by 152 · see citing works
Lu, D., Tang, C., Chen, Y., & Wei, I. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22580 · Cited by 151 · see citing works
PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
Rasbach, K. A., Gupta, R. K., Ruas, J. L., Wu, J., Naseri, E., Estall, J. L., & Spiegelman, B. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016089107 · Cited by 142 · see citing works
Yokota, T., Kinugawa, S., Hirabayashi, K., Matsushima, S., Inoue, N., Ohta, Y., Hamaguchi, S., Sobirin, M. A., Ono, T., Suga, T., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00267.2009 · Cited by 139 · see citing works
Muoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-083 · Cited by 129 · see citing works
Hyperglycemia decreases mitochondrial function: The regulatory role of mitochondrial biogenesis
Palmeira, C. M., Rolo, A. P., Berthiaume, J. M., Bjork, J. A., & Wallace, K. B. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.07.015 · Cited by 123 · see citing works
Self-citationLu, S.-S., Yu, Y.-L., Zhu, H., Liu, X., Liu, L., Liu, Y.-W., Wang, P., Xie, L. Y., & Wang, G.-J. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0419 · Cited by 111 · see citing works
Berberine inhibits PTP1B activity and mimics insulin action
Chen, C., Zhang, Y., & Huang, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.153 · Cited by 106 · see citing works
Nutrient-Induced Insulin Resistance in Human Skeletal Muscle
Krebs, M., & Roden, M. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043455620 · Cited by 82 · see citing works
Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.
Choi, M. S., Yuk, D. Y., Oh, J. H., Jung, H. Y., Han, S., Moon, D. C., & Hong, J. T. (2008) · PubMed · Cited by 80 · see citing works
Berberine acutely activates the glucose transport activity of GLUT1
Cok, A., Rosenberger, C. L., Salie, M. J., Oram, D. S., Chenge, J., & Louters, L. L. (2011) · Biochimie · doi:10.1016/j.biochi.2011.04.013 · Cited by 73 · see citing works
Wang, Z., Lu, F., Leng, S.-H., Fang, X., Chen, G., Wang, Z.-S., Dong, L., & Yan, Z.-Q. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6004 · Cited by 61 · see citing works
Pereira, C. V., Machado, N. G., & Oliveira, P. J. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn131 · Cited by 58 · see citing works
Bova, S., Padrini, R., Goldman, W. F., Berman, D. M., & Cargnelli, G. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10978-6 · Cited by 56 · see citing works
Mitochondrially mediated synergistic cell killing by bile acids
Rolo, A. P., Palmeira, C. M., & Wallace, K. B. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00224-7 · Cited by 55 · see citing works
Self-citationJones, J. G., Fagulha, A., Barosa, C., Bastos, M., Barros, L. M., Baptista, C. F., Caldeira, M. M., & Carvalheiro, M. C. (2006) · Diabetes · doi:10.2337/db06-0304 · Cited by 33 · see citing works
Self-citationVarela, A. T. I. F., Gomes, A. P., Simões, A. M., Teodoro, J. S., Duarte, F. V., Rolo, A. P., & Palmeira, C. M. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.08.005 · Cited by 24 · see citing works
Self-citation
Flagged first, then by citations
1 of the 61 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602 · see citing works
Self-citationGomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works
Self-citationBiological properties and clinical applications of berberine
Song, D., Hao, J., & Fan, D. (2020) · Frontiers of Medicine · doi:10.1007/s11684-019-0724-6 · Cited by 510 · see citing works
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.
O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364 · see citing works
Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
Di Meo, S., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0598 · Cited by 282 · see citing works
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 262 · see citing works
Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review
Wu, J., Shi, S., Wang, H., & Wang, S. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.02.040 · Cited by 242 · see citing works
Dietary Regulation of Oxidative Stress in Chronic Metabolic Diseases
Jiang, S., Liu, H., & Li, C. (2021) · Foods · doi:10.3390/foods10081854 · Cited by 230 · see citing works
Chang, W., Chen, L., & Hatch, G. M. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0107 · Cited by 159 · see citing works
Insulin Resistance and Mitochondrial Dysfunction
González-Franquesa, A., & Patti, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_25 · Cited by 154 · see citing works
Rato, L., Duarte, A. I., Tomás, G. D., Santos, M. S., Moreira, P. I., Socorro, S., Cavaco, J. E. B., Alves, M. G., & Oliveira, P. F. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.12.008 · Cited by 154 · see citing works
Sun, Y., Xia, M., Yan, H., Han, Y., Zhang, F., Hu, Z., Cui, A., Ma, F., Liu, Z., Gong, Q., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14079 · Cited by 150 · see citing works
The Role of microRNAs in Mitochondria: Small Players Acting Wide
Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2014) · Genes · doi:10.3390/genes5040865 · Cited by 151 · see citing works
Self-citationHuang, Z., Han, Z., Ye, B., Dai, Z., Shan, P., Lu, Z., Dai, K., Wang, C., & Huang, W. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.028 · Cited by 151 · see citing works
Guo, P., Pi, H., Xu, S., Zhang, L., Li, Y., Li, M., Cao, Z., Li, T. X., Xie, J., Li, R., et al. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu164 · Cited by 132 · see citing works
Rafiei, H., Omidian, K., & Bandy, B. (2019) · Nutrients · doi:10.3390/nu11030541 · Cited by 130 · see citing works
Yu, L., Li, Q., Yu, B., Yang, Y., Jin, Z., Duan, W., Zhao, G., Zhai, M., Liu, L., Yi, D., et al. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1689602 · Cited by 122 · see citing works
Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway
Wu, Y., Zhang, L., Wu, Z., Shan, T.-T., & Xiong, C. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2150394 · Cited by 121 · see citing works
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62556 · Cited by 110 · see citing works
Belwal, T., Bisht, A., Devkota, H. P., Ullah, H., Khan, H. Z., Pandey, A., BHATT, I. D., & Echeverría, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00041 · Cited by 115 · see citing works
Teodoro, J. S., Duarte, F. V., Gomes, A. P., Varela, A. T. I. F., Peixoto, F., Rolo, A. P., & Palmeira, C. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.09.002 · Cited by 111 · see citing works
Self-citationYu, Y., Zhao, Y., Teng, F., Li, J., Guan, Y., Xu, J., Lv, X., Guan, F., Zhang, M., & Chen, L. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1015-7 · Cited by 110 · see citing works
Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure
Abudureyimu, M., Yu, W., Cao, R. Y., Zhang, Y., Liu, H., & Zheng, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565751 · Cited by 108 · see citing works
Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
Jeong, J., Moon, M., Lee, Y.-J., Seol, J., & Park, S. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.04.002 · Cited by 102 · see citing works
Fields, J. A., Serger, E., Campos, S., Divakaruni, A. S., Kim, C., Smith, K., Trejo, M., Adame, A., Spencer, B. J., Rockenstein, E. M., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.11.015 · Cited by 101 · see citing works
Berberine alleviates nonalcoholic fatty liver induced by a high‐fat diet in mice by activating SIRT3
Xu, X., Zhu, X., Bai, J., Xia, P., Li, Y., Lü, Y., Li, X.-Y., & Gao, X. (2019) · The FASEB Journal · doi:10.1096/fj.201802316r · Cited by 86 · see citing works
Xu, J. H., Liu, X., Pan, W., & Zou, D. J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6321 · Cited by 86 · see citing works
The Emerging Role of MitomiRs in the Pathophysiology of Human Disease
Duarte, F. V., Palmeira, C. M., & Rolo, A. P. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-22671-2_8 · Cited by 81 · see citing works
Self-citationDeng, Y., Tang, K., Chen, R., Nie, H., Shu, L., Zhang, J., Zhang, Y., & Yang, Q. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7208 · Cited by 79 · see citing works
Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated H9c2 cardiomyoblasts
Coelho, A. R., Martins, T. R., Couto, R., Deus, C. M., Pereira, C. V., Simões, R. F., Rizvanov, A. A., Silva, F. S. G., Cunha‐Oliveira, T., Oliveira, P. J., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.030 · Cited by 78 · see citing works
Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect
Giovannini, L., & Bianchi, S. E. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.008 · Cited by 77 · see citing works
Zhang, Y., Deng, Y., Tang, K., Chen, R.-S., Shu, L., Liang, Y., Li, H., Jin, L., Liang, Z., Chen, Y., et al. (2019) · Current Medical Science · doi:10.1007/s11596-019-1997-3 · Cited by 76 · see citing works
Lee, J., Moon, J.-H., Kim, S.-W., Jeong, J., Nazim, U. M., Lee, Y.-J., Seol, J., & Park, S. (2015) · Oncotarget · doi:10.18632/oncotarget.3832 · Cited by 76 · see citing works
MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes
Latouche, C., Natoli, A., Reddy-Luthmoodoo, M., Heywood, S. E., Armitage, J. A., & Kingwell, B. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155108 · Cited by 72 · see citing works
Using mitochondrial sirtuins as drug targets: disease implications and available compounds
Gertz, M., & Steegborn, C. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2180-7 · Cited by 71 · see citing works
miR-378a: a new emerging microRNA in metabolism
Machado, I. F., Teodoro, J. S., Palmeira, C. M., & Rolo, A. P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03375-z · Cited by 69 · see citing works
Self-citationResearch progress on the pharmacological effects of berberine targeting mitochondria
Fang, X., Wu, H., Wei, J., Miao, R., Zhang, Y., & Tian, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.982145 · Cited by 72 · see citing works
Geng, F., Li, G., Zhang, X., Zhang, P., Dong, M., Zhao, Z., Zhang, Y., Dong, L., & Gao, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13466 · Cited by 68 · see citing works
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
Li, H., Wang, X.-C., Xu, Y., Luo, N., Luo, S., Hao, X.-Y., Cheng, S., Fang, J., Wang, Q., Zhang, S., et al. (2017) · Rejuvenation Research · doi:10.1089/rej.2017.1972 · Cited by 67 · see citing works
Nutraceutical Activation of Sirt1: A Review
DiNicolantonio, J. J., McCarty, M. F., & O'Keefe, J. H. (2022) · Open Heart · doi:10.1136/openhrt-2022-002171 · Cited by 65 · see citing works
Nie, Q., Li, M., Huang, C., Yongwei, Y., Liang, Q., Ma, X., Qiu, T., & Li, J. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05011-2 · Cited by 65 · see citing works
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
Yang, J., Suo, H., & Song, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1809344 · Cited by 66 · see citing works
Fan, J., Fan, J., & Khanzada, Z. (2025) · Muscles · doi:10.3390/muscles4030026 · Cited by 64 · see citing works
The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease
Zhu, X., Bian, H., & Gao, X. (2016) · Molecules · doi:10.3390/molecules21101336 · Cited by 62 · see citing works
Metformin attenuates osteoarthritis by targeting chondrocytes, synovial macrophages and adipocytes
Li, D., Ruan, G., Zhang, Y., Zhao, Y., Zhu, Z., Ou, Q., Huang, H., Chen, J., Han, W., Tang, S., et al. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac467 · Cited by 61 · see citing works
Tan, M., Tang, C., Zhang, Y., Cheng, Y., Cai, L., Chen, X., Gao, Y., Deng, Y., & Pan, M. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1016020 · Cited by 61 · see citing works
Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations
Liang, K. X., Kristiansen, C. K., Mostafavi, S., Vatne, G. H., Zantingh, G. A., Kianian, A., Tzoulis, C., Høyland, L. E., Ziegler, M., Pérez, R., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012146 · Cited by 60 · see citing works
Cell-specific pattern of berberine pleiotropic effects on different human cell lines
Agnarelli, A., Natali, M., Garcia‐Gil, M., Pesi, R., Tozzi, M. G., Ippolito, C., Bernardini, N., Vignali, R., Batistoni, R., Bianucci, A. M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-28952-3 · Cited by 57 · see citing works
Lin, Y., Sheng, M., Weng, Y., Xu, R., Lü, N., Du, H., & Yu, W. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.028 · Cited by 56 · see citing works
Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice
Zhang, P., Ma, D., Wang, Y., Zhang, M., Qiang, X., Liao, M., Xie, L., Wu, H., & Zhang, Y. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.10.005 · Cited by 55 · see citing works
Purohit, P., & Saini, N. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03670-0 · Cited by 40 · see citing works
Binding of plant alkaloids berberine and palmatine to serum albumins: a thermodynamic investigation
Khan, A. Y., Hossain, M., & Kumar, G. S. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2092-z · Cited by 53 · see citing works
Abu Bakar, M. H., Shariff, K. A., Tan, J. S., & Lee, L. K. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173371 · Cited by 51 · see citing works
Barhwal, K. K., Das, S. K., Kumar, A., Hota, S. K., & Srivastava, R. B. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13225 · Cited by 50 · see citing works
RetractedRafiei, H., Omidian, K., & Bandy, B. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600781 · Cited by 51 · see citing works
Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
Shan, Y., Zhang, S., Gao, B., Liang, S., Zhang, H., Yu, X., Zhao, J., Ye, L., Yang, Q., & Shang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.591227 · Cited by 49 · see citing works
Berberine prevents NAFLD and HCC by modulating metabolic disorders.
Lin, X., Zhang, J.-H., Chu, Y., Nie, Q.-Y., & Zhang, J.-M. (2024) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2024.108593 · Cited by 52 · see citing works
Natural products: Potential therapeutic agents to prevent skeletal muscle atrophy.
Yadav, A., Yadav, S., Singh, S., & Dabur, R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174995 · Cited by 45 · see citing works
Chen, D., & Yang, K. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26089 · Cited by 45 · see citing works
High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes
Teodoro, J. S., Varela, A. T. I. F., Rolo, A. P., & Palmeira, C. M. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0406-6 · Cited by 42 · see citing works
Self-citationCombination of Berberine with Resveratrol Improves the Lipid-Lowering Efficacy
Zhu, X., Yang, J., Zhu, W., Yin, X., Yang, B., Wei, Y., & Guo, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123903 · Cited by 43 · see citing works
Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury
Machado, I. F., Palmeira, C. M., & Rolo, A. P. (2023) · Biomedicines · doi:10.3390/biomedicines11030948 · Cited by 41 · see citing works
Self-citationLi, S., Gaur, U., Chong, C., Lin, S., Fang, J., Zeng, Z., Wang, H., & Zheng, W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061736 · Cited by 41 · see citing works
Hassanein, E. H. M., Kamel, E. O., Ali, F. E. M., & Ahmed, M. A. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119754 · Cited by 39 · see citing works
Azzolini, M., Mattarei, A., Spina, M. L., Fanin, M., Chiodarelli, G., Romio, M., Zoratti, M., Paradisi, C., & Biasutto, L. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.02.017 · Cited by 38 · see citing works
Ma, H., He, K., Zhu, J., Li, X., & Ye, X. (2019) · Fitoterapia · doi:10.1016/j.fitote.2019.03.003 · Cited by 37 · see citing works
Marcinko, K., Bujak, A. L., Lally, J., Ford, R. J., Wong, T. H., Smith, B. K., Kemp, B. E., Jenkins, Y., Li, W., Kinsella, T. M., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.002 · Cited by 35 · see citing works
The multifaceted roles of natural products in mitochondrial dysfunction
Chen, Q., Ruan, D., Shi, J., Du, D., & Bian, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1093038 · Cited by 36 · see citing works
Exploiting Common Aspects of Obesity and Alzheimer’s Disease
Tabassum, S., Misrani, A. A., & Yang, L. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.602360 · Cited by 36 · see citing works
SIRT1 activation attenuates palmitate induced apoptosis in C2C12 muscle cells
Taheripak, G., Sabeti, N., Najar, N., Razavi, Z., Saharkhiz, S., & Alipourfard, I. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09250-w · Cited by 33 · see citing works
Pharmacological properties and therapeutic potential of berberine: a comprehensive review
Fan, K.-Q., Zhang, L., Song, F., Zhang, Y., Chen, T., Cheng, X., Su, N., Zou, Y., Yu, T., Tan, F., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1604071 · Cited by 33 · see citing works
Lin, Y., Sheng, M., Ding, Y., Zhang, N., Song, Y., Du, H., Lü, N., & Yu, W. (2018) · Journal of Natural Medicines · doi:10.1007/s11418-018-1210-1 · Cited by 33 · see citing works
Javadipour, M., Rezaei, M., Keshtzar, E., & Khodayar, M. J. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22368 · Cited by 33 · see citing works
Li, P., Song, X., Zhang, D., Guo, N., Wu, C., Chen, K., Liu, Y., Yuan, L., Chen, X., & Huang, X. (2019) · BioFactors · doi:10.1002/biof.1584 · Cited by 33 · see citing works
Uncoupling proteins as a therapeutic target to protect the diabetic heart
Dludla, P. V., Nkambule, B. B., Tiano, L., Louw, J., Jastroch, M., & Mazibuko-Mbeje, S. E. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.013 · Cited by 32 · see citing works
Berberine Ameliorates Hepatic Insulin Resistance by Regulating microRNA-146b/SIRT1 Pathway
Sui, M., Jiang, X., Sun, H., Liu, C., & Fan, Y. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s313068 · Cited by 32 · see citing works
Han, J. Y., Park, S. H., Yang, J. H., Kim, M. G., Cho, S., Yoon, G., Cheon, S. H., & Ki, S. H. (2014) · Toxicological Research · doi:10.5487/tr.2014.30.1.019 · Cited by 31 · see citing works
Rezaei, M., Keshtzar, E., Khodayar, M. J., & Javadipour, M. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.10.025 · Cited by 30 · see citing works
Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells
Seo, D.-B., Jeong, H. W., Lee, S.-J., & Lee, S. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf404882w · Cited by 30 · see citing works
Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
Wang, S., Kang, Y., Wang, R., Deng, J., Yu, Y., Yu, J. J., & Wang, J. (2022) · Molecules · doi:10.3390/molecules27248754 · Cited by 28 · see citing works
Jun, L., Tao, Y.-X., Geetha, T., & Babu, J. R. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00555-7 · Cited by 27 · see citing works
Chappell, W. H., Abrams, S. L., Franklin, R. A., LaHair, M. M., Montalto, G., Cervello, M., Martelli, A. M., Nicoletti, F., Candido, S., Libra, M., et al. (2012) · Cell Cycle · doi:10.4161/cc.22786 · Cited by 27 · see citing works
Araj‐Khodaei, M., Ayati, M. H., Azizi-Zeinalhajlou, A., Novinbahador, T., Yousefi, M., Shiri, M., Mahmoodpoor, A., Shamekh, A., Namazi, N., & Sanaie, S. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2258559 · Cited by 30 · see citing works
Kurniawan, A. L., Lee, Y., Shih, C., Hsieh, R., Chen, S., & Chang, J. (2019) · Food & Function · doi:10.1039/c8fo01870g · Cited by 26 · see citing works
Wu, Y. S., Li, Z. M., Chen, Y. T., Dai, S. J., Zhou, X. J., Yang, Y. X., Lou, J. S., Ji, L. T., Bao, Y. T., Xuan, L., et al. (2020) · Journal of Immunology Research · doi:10.1155/2020/2141508 · Cited by 25 · see citing works
Lee, I., Chao, C., Yang, Y.-C., Cheng, J., Huang, C., Chiou, C., Huang, H., Kuo, Y., & Huang, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111170 · Cited by 25 · see citing works
Mahmoud, A. M., Abdel-Rahman, M. M., Bastawy, N., & Eissa, H. (2017) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2017.70401 · Cited by 25 · see citing works
An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity
Pereira, L. C., Duarte, F. V., Varela, A. T. I. F., Rolo, A. P., Palmeira, C. M., & Dorta, D. J. (2016) · Toxicology · doi:10.1016/j.tox.2016.05.022 · Cited by 24 · see citing works
Self-citationShi, Z., Li, X., Peng, Z.-C., Peng, Z., Zhao, C.-X., Du, X.-L., Fang, Z.-Y., Fang, Z., Liu, G.-W., & Liu, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061691 · Cited by 24 · see citing works
Cost-effectiveness of immunization in The Gambia.
Robertson, R. L., Foster, S. O., Hull, H. F., & Williams, P. J. (1985) · PubMed · Cited by 24 · see citing works
Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status
Lu, J., Cao, Y., Cheng, K., Xu, B., Wang, T., Yang, Q., Yang, Q., Feng, X., & Xia, Q. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.04.006 · Cited by 23 · see citing works
Zou, D., Liu, P., Chen, K., Xie, Q., Liang, X., Bai, Q., Zhou, Q., Liu, K., Zhang, T., Zhu, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124727 · Cited by 23 · see citing works
Berberine improves intralipid-induced insulin resistance in murine
Dong, Z.-H., Lin, H., Chen, F., Che, X.-Q., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0493-4 · Cited by 23 · see citing works
Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status
Wang, L., Sagada, G., Wang, C., Gao, C. Y., Wang, B., Shao, Q., & Yan, Y. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.967748 · Cited by 22 · see citing works
G-quadruplex-mediated reduction of a pathogenic mitochondrial heteroplasmy
Naeem, M. M., Maheshan, R., Costford, S. R., Wahedi, A., Trajkovski, M., Plavec, J., Yatsunyk, L. A., Ciesielski, G. L., Kaufman, B. A., & Sondheimer, N. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz153 · Cited by 21 · see citing works
Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives
Yan, L.-S., Cheng, B. C., Zhang, S., Luo, G., Zhang, C., Wang, Q.-G., Fu, X., Wang, Y., & Zhang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.748500 · Cited by 21 · see citing works
BinMowyna, M. N., AlFaris, N. A., AL-SANEA, E. A., ALTAMIMI, J. Z., & Aldayel, T. S. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2022.2046106 · Cited by 21 · see citing works
Wu, K., Chen, G., Högstrand, C., Ling, S.-C., Wu, L., & Luo, Z. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126732 · Cited by 21 · see citing works
Inhibition of mTOR/S6K1/4E-BP1 Signaling by Nutraceutical SIRT1 Modulators
Bianchi, S. E., & Giovannini, L. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1446093 · Cited by 20 · see citing works
Xu, J. F., Zhang, Y., Yu, Z., Guan, Y., Lv, Y., Zhang, M., Zhang, M., Chen, L., Lv, X., & Guan, F. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022146 · Cited by 20 · see citing works
- Authors
- Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P.
- Affiliations
- Harvard University (US)
- Centro de Neurociências e Biologia Celular (PT)
- Corresponding author
- Palmeira, Carlos M.
- Rolo, Anabela P.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 1822
- Issue
- 2
- Pages
- 185-195
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3366688
- OpenAlex
- W2016281492
- Cited by
- 159
- References
- 61
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Portuguese Foundation for Science and Technology
- NIH/NIA
- Topics
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- berberine, SIRT1, mitochondrial biogenesis, skeletal muscle mitochondria, mitochondrial dysfunction, high-fat diet, insulin resistance, AMPK, hyperglycemia, SIRT1 knockdown
- MeSH terms
- Animals, Berberine, Organelle Biogenesis, Cell Line, Glucose, Hormones, Hyperglycemia, Insulin Resistance, Male, Mitochondria, Mitochondria, Muscle, NAD, Obesity, Phosphorylation, Rats, Sprague-Dawley, Muscle, Skeletal, Myoblasts, Mice, Rats, AMP-Activated Protein Kinases, Sirtuin 1, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
