Sinclair, David A.

The Information Theory of Aging

Lu, Y. R., Tian, X., & Sinclair, D. A. (2023) · Nature Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 141

Chemically induced reprogramming to reverse cellular aging

Yang, J.-H., Petty, C. A., Dixon-McDougall, T., Lopez, M. V., Tyshkovskiy, A., Maybury-Lewis, S., Tian, X., Ibrahim, N., Chen, Z., Griffin, P. T., et al. (2023) · Aging

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 136

Why NAD + Declines during Aging: It’s Destroyed

Schultz, M. B., & Sinclair, D. A. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 126

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

Rutanen, J., Yaluri, N., Modi, S., Pihlajamäki, J., Vänttinen, M., Itkonen, P., Kainulainen, S., Yamamoto, H., Lagouge, M., Sinclair, D. A., et al. (2010) · Diabetes

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 104

Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice

Uddin, G. M., Youngson, N. A., Sinclair, D. A., & Morris, M. J. (2016) · Frontiers in Pharmacology

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 95

Resveratrol Inhibits Pathologic Retinal Neovascularization in Vldlr−/−Mice

Hua, J., Guerin, K. I., Chen, J., Michán, S., Stahl, A., Krah, N. M., Seaward, M. R., Dennison, R. J., Juan, A. M., Hatton, C. J., et al. (2011) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsSirtuins and Resveratrol in Medicine

Cited by 94

Dietary restriction: standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 76

Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming

Cipriano, A., Moqri, M., Maybury-Lewis, S. Y., Rogers-Hammond, R., de Jong, T. A., Parker, A., Rasouli, S., Schöler, H. R., Sinclair, D. A., & Sebastiano, V. (2023) · Nature Aging

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 66

NAD+ in COVID-19 and viral infections

Zheng, M., Schultz, M. B., & Sinclair, D. A. (2022) · Trends in Immunology

Sirtuins and Resveratrol in MedicineInflammasome and immune disorders

Cited by 62

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

Kim, J., Sturgill, D., Tran, A. D., Sinclair, D. A., & Oberdoerffer, P. (2016) · Nucleic Acids Research

DNA Repair MechanismsEpigenetics and DNA Methylation

Cited by 62

SIRT1 limits adipocyte hyperplasia through c-Myc inhibition

Abdesselem, H., Madani, A., Hani, A., Al-Noubi, M., Goswami, N., Ben Hamidane, H., Billing, A. M., Pasquier, J., Bonkowski, M. S., Halabi, N., et al. (2016) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 56

Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

Ross, J. M., Coppotelli, G., Branca, R. M., Kim, K. M., Lehtiö, J., Sinclair, D. A., & Olson, L. (2019) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 41

Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals

Yang, J.-H., Griffin, P. T., Vera, D. L., Apostolides, J. K., Hayano, M., Meer, M. V., Salfati, E. L., Su, Q., Munding, E. M., Blanchette, M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 38

Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma

Karg, M. M., Lu, Y. R., Refaian, N., Cameron, J., Hoffmann, E., Hoppe, C., Shirahama, S., Shah, M., Krasniqi, D., Krishnan, A., et al. (2023) · Cellular Reprogramming

Retinal Development and DisordersGlaucoma and retinal disorders

Cited by 34

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Uddin, G. M., Youngson, N. A., Chowdhury, S. S., Hagan, C., Sinclair, D. A., & Morris, M. J. (2020) · Cells

Sirtuins and Resveratrol in MedicineBirth, Development, and Health

Cited by 32

Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming

Lu, Y., Krishnan, A., Brommer, B., Tian, X., Meer, M., Vera, D. L., Wang, C., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Epigenetics and DNA MethylationRetinal Development and Disorders

Cited by 20