Wink, David A.

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

Heinecke, J. L., Ridnour, L. A., Cheng, R. Y. S., Switzer, C. H., Lizardo, M. M., Khanna, C., Glynn, S. A., Hussain, S. P., Young, H. A., Ambs, S., et al. (2014) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsImmune cells in cancer

Cited by 177

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

Switzer, C. H., Cheng, R. Y. S., Vitek, T. M., Christensen, D. J., Wink, D. A., & Vitek, M. P. (2011) · Oncogene

Protein Kinase Regulation and GTPase SignalingMechanisms of cancer metastasis

Cited by 171

Signaling and stress: The redox landscape in NOS2 biology

Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., et al. (2015) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 150

S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer

Switzer, C. H., Glynn, S. A., Cheng, R. Y.-S., Ridnour, L. A., Green, J. E., Ambs, S., & Wink, D. A. (2012) · Molecular Cancer Research

HER2/EGFR in Cancer ResearchNitric Oxide and Endothelin Effects

Cited by 141

NO synthase 2 ( NOS2 ) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease

Colton, C. A., Vitek, M. P., Wink, D. A., Xu, Q., Cantillana, V., Previti, M. L., Van Nostrand, W. E., Weinberg, J. B., & Dawson, H. (2006) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 128

Effect of Superoxide Dismutase on the Stability ofS-Nitrosothiols

Jourd'heuil, D., Laroux, F. S., Miles, A. M., Wink, D. A., & Grisham, M. B. (1999) · Archives of Biochemistry and Biophysics

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 123

Superoxide fluxes limit nitric oxide-induced signaling

Thomas, D. D., Ridnour, L. A., Espey, M. G., Donzelli, S., Ambs, S., Hussain, S. P., Harris, C. C., DeGraff, W., Roberts, D. D., Mitchell, J. B., et al. (2006) · Journal of Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 121

Discriminating formation of HNO from other reactive nitrogen oxide species

Donzelli, S., Espey, M. G., Thomas, D. D., Mancardi, D., Tocchetti, C. G., Ridnour, L. A., Paolocci, N., King, S. B., Miranda, K. M., Lazzarino, G., et al. (2006) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 112

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-l-arginine

Donzelli, S., Espey, M. G., Flores-Santana, W., Switzer, C. H., Yeh, G. C., Huang, J., Stuehr, D. J., King, S. B., Miranda, K. M., & Wink, D. A. (2008) · Free Radical Biology and Medicine

Hemoglobin structure and functionNitric Oxide and Endothelin Effects

Cited by 91

Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers

de Oliveira, G. A., Cheng, R. Y. S., Ridnour, L. A., Basudhar, D., Somasundaram, V., McVicar, D. W., Monteiro, H. P., & Wink, D. A. (2017) · Antioxidants & Redox Signaling

Nitric Oxide and Endothelin EffectsInflammatory mediators and NSAID effects

Cited by 91

Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer

Switzer, C. H., Cheng, R. Y.-S., Ridnour, L. A., Glynn, S. A., Ambs, S., & Wink, D. A. (2012) · Breast Cancer Research

Breast Cancer Treatment StudiesEstrogen and related hormone effects

Cited by 91

Heme Proteins and Nitric Oxide (NO): The Neglected, Eloquent Chemistry in NO Redox Signaling and Regulation

Thomas, D. D., Miranda, K. M., Colton, C. A., Citrin, D., Espey, M. G., & Wink, D. A. (2003) · Antioxidants & Redox Signaling

Hemoglobin structure and functionMetal-Catalyzed Oxygenation Mechanisms

Cited by 89

Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species

Sidorkina, O., Espey, M. G., Miranda, K. M., Wink, D. A., & Laval, J. (2003) · Free Radical Biology and Medicine

Redox biology and oxidative stressPARP inhibition in cancer therapy

Cited by 79

Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems

Thomas, D. D., Miranda, K. M., Graham Espey, M., Citrin, D., Jourd'heuil, D., Paolocci, N., Hewett, S. J., Colton, C. A., Grisham, M. B., Feelisch, M., et al. (2002) · Methods in Enzymology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 76

Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer

Switzer, C. H., Glynn, S. A., Ridnour, L. A., Cheng, R. Y.-S., Vitek, M. P., Ambs, S., & Wink, D. A. (2011) · Trends in Pharmacological Sciences

Breast Cancer Treatment StudiesNitric Oxide and Endothelin Effects

Cited by 74

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation

Ridnour, L. A., Barasch, K. M., Windhausen, A. N., Dorsey, T. H., Lizardo, M. M., Yfantis, H. G., Lee, D. H., Switzer, C. H., Cheng, R. Y. S., Heinecke, J. L., et al. (2012) · PLoS ONE

Protease and Inhibitor MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 71

Nitric oxide‐mediated regulation of ‐amyloid clearance via alterations of MMP‐9/TIMP‐1

Ridnour, L. A., Dhanapal, S., Hoos, M., Wilson, J., Lee, J., Cheng, R. Y. S., Brueggemann, E. E., Hines, H. B., Wilcock, D. M., Vitek, M. P., et al. (2012) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsProtease and Inhibitor Mechanisms

Cited by 54

Comparing the chemical biology of NO and HNO

Flores-Santana, W., Switzer, C., Ridnour, L. A., Basudhar, D., Mancardi, D., Donzelli, S., Thomas, D. D., Miranda, K. M., Fukuto, J. M., & Wink, D. A. (2009) · Archives of Pharmacal Research

Nitric Oxide and Endothelin EffectsHemoglobin structure and function

Cited by 50

Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death

Gbadegesin, M., Vicini, S., Hewett, S. J., Wink, D. A., Espey, M., Pluta, R. M., & Colton, C. A. (1999) · American Journal of Physiology-Cell Physiology

Neuroscience and Neuropharmacology ResearchNitric Oxide and Endothelin Effects

Cited by 47

Nitroxyl anion regulation of the NMDA receptor

Colton, C. A., Gbadegesin, M., Wink, D. A., Miranda, K. M., Espey, M. G., & Vicini, S. (2001) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchNitric Oxide and Endothelin Effects

Cited by 45

Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: insights into listeriocidal activity of oxidative and nitrosative stress

Ogawa, R., Pacelli, R., Espey, M. G., Miranda, K. M., Friedman, N., Kim, S., Cox, G., Mitchell, J. B., Wink, D. A., & Russo, A. (2001) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 35