Wink, David A.

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 1,606

The chemical biology of nitric oxide: Implications in cellular signaling

Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 975

Cannabidiol and (−)Δ 9 -tetrahydrocannabinol are neuroprotective antioxidants

Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998) · Proceedings of the National Academy of Sciences

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 850

Nitric oxide and redox mechanisms in the immune response

Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 765

Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects

Maragos, C. M., Morley, D., Wink, D. A., Dunams, T. M., Saavedra, J. E., Hoffman, A., Bove, A. A., Isaac, L., Hrabie, J. A., & Keefer, L. K. (1991) · Journal of Medicinal Chemistry

Nitric Oxide and Endothelin EffectsStructural and Chemical Analysis of Organic and Inorganic Compounds

Cited by 722

The multifaceted roles of nitric oxide in cancer

Wink, D. (1998) · Carcinogenesis

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 682

Methods for detection of reactive metabolites of oxygen and nitrogen: In vitro and in vivo considerations

Tarpey, M. M., Wink, D. A., & Grisham, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 673

“NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms

Keefer, L. K., Nims, R. W., Davies, K. M., & Wink, D. A. (1996) · Methods in Enzymology

Nitric Oxide and Endothelin EffectsStructural and Chemical Analysis of Organic and Inorganic Compounds

Cited by 670

The emerging biology of the nitrite anion

Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 609

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

Wink, D. A., Darbyshire, J. F., Nims, R. W., Saavedra, J. E., & Ford, P. C. (1993) · Chemical Research in Toxicology

Nitric Oxide and Endothelin EffectsFree Radicals and Antioxidants

Cited by 480

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: Implications of their possible biological activity and utility

Ono, K., Akaike, T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., et al. (2014) · Free Radical Biology and Medicine

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 422

Autoxidation kinetics of aqueous nitric oxide

Ford, P. C., Wink, D. A., & Stanbury, D. M. (1993) · FEBS Letters

Nitric Oxide and Endothelin EffectsFree Radicals and Antioxidants

Cited by 419

Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species

Fukuto, J. M., Carrington, S. J., Tantillo, D. J., Harrison, J. G., Ignarro, L. J., Freeman, B. A., Chen, A., & Wink, D. A. (2012) · Chemical Research in Toxicology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 389

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Hofseth, L. J., Saito, S., Hussain, S. P., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., et al. (2003) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysRedox biology and oxidative stress

Cited by 355

The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations

Ridnour, L. A., Thomas, D. D., Mancardi, D., Espey, M. G., Miranda, K. M., Paolocci, N., Feelisch, M., Fukuto, J., & Wink, D. A. (2004) · Biological Chemistry

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 312

Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide

Thomas, D. D., Espey, M. G., Ridnour, L. A., Hofseth, L. J., Mancardi, D., Harris, C. C., & Wink, D. A. (2004) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismNitric Oxide and Endothelin Effects

Cited by 289

A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system

Miranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., Espey, M. G., Kass, D. A., Feelisch, M., Fukuto, J. M., et al. (2003) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 283

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

Isenberg, J. S., Ridnour, L. A., Perruccio, E. M., Espey, M. G., Wink, D. A., & Roberts, D. D. (2005) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerNitric Oxide and Endothelin Effects

Cited by 273

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

Weiss, J. M., Davies, L. C., Karwan, M., Ileva, L., Ozaki, M. K., Cheng, R. Y. S., Ridnour, L. A., Annunziata, C. M., Wink, D. A., & McVicar, D. W. (2018) · Journal of Clinical Investigation

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 267

Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients

Glynn, S. A., Boersma, B. J., Dorsey, T. H., Yi, M., Yfantis, H. G., Ridnour, L. A., Martin, D. N., Switzer, C. H., Hudson, R. S., Wink, D. A., et al. (2010) · Journal of Clinical Investigation

Breast Cancer Treatment StudiesEstrogen and related hormone effects

Cited by 254

The biphasic nature of nitric oxide responses in tumor biology

Ridnour, L. A., Thomas, D. D., Donzelli, S., Espey, M. G., Roberts, D. D., Wink, D. A., & Isenberg, J. S. (2006) · Antioxidants & Redox Signaling

Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in Cancer

Cited by 247

Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites

Immune cells in cancerNitric Oxide and Endothelin Effects

Cited by 237

Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways

Ridnour, L. A., Windhausen, A. N., Isenberg, J. S., Yeung, N., Thomas, D. D., Vitek, M. P., Roberts, D. D., & Wink, D. A. (2007) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsNitric Oxide and Endothelin Effects

Cited by 219

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

Isenberg, J. S., Romeo, M. J., Yu, C., Yu, C. K., Nghiem, K., Monsale, J., Rick, M. E., Wink, D. A., Frazier, W. A., & Roberts, D. D. (2008) · Blood

Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms

Cited by 205