D’Alessandro, Angelo

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Pollyea, D. A., Stevens, B. M., Jones, C. L., Winters, A., Pei, S., Minhajuddin, M., D’Alessandro, A., Culp-Hill, R., Riemondy, K. A., Gillen, A. E., et al. (2018) · Nature Medicine

Acute Myeloid Leukemia ResearchChronic Myeloid Leukemia Treatments

Cited by 778

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

Thomas, T., Stefanoni, D., Reisz, J. A., Nemkov, T., Bertolone, L., Francis, R. O., Hudson, K. E., Zimring, J. C., Hansen, K. C., Hod, E. A., et al. (2020) · JCI Insight

COVID-19 Clinical Research StudiesTryptophan and brain disorders

Cited by 586

The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease

Lonnemann, N., Hosseini, S., Marchetti, C., Skouras, D. B., Stefanoni, D., D’Alessandro, A., Dinarello, C. A., & Korte, M. (2020) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsInflammasome and immune disorders

Cited by 298

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

Dong, S., Wang, Q., Kao, Y.-R., Diaz, A., Tasset, I., Kaushik, S., Thiruthuvanathan, V., Zintiridou, A., Nieves, E., Dzieciatkowska, M., et al. (2021) · Nature

Autophagy in Disease and TherapyHematopoietic Stem Cell Transplantation

Cited by 275

Mitochondrial complex I activity in microglia sustains neuroinflammation

Peruzzotti-Jametti, L., Willis, C. M., Krzak, G., Hamel, R., Pirvan, L., Ionescu, R.-B., Reisz, J. A., Prag, H. A., Garcia-Segura, M. E., Wu, V., et al. (2024) · Nature

Neuroinflammation and Neurodegeneration MechanismsMitochondrial Function and Pathology

Cited by 239

Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle

Perreault, L., Newsom, S. A., Strauss, A., Kerege, A., Kahn, D. E., Harrison, K. A., Snell-Bergeon, J. K., Nemkov, T., D’Alessandro, A., Jackman, M. R., et al. (2018) · JCI Insight

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 184

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Traxler, L., Herdy, J. R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R. K., Schlachetzki, J. C. M., et al. (2022) · Cell Metabolism

Alzheimer's disease research and treatmentsCancer, Hypoxia, and Metabolism

Cited by 179

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Jones, C. L., Stevens, B. M., D’Alessandro, A., Culp-Hill, R., Reisz, J. A., Pei, S., Gustafson, A., Khan, N., DeGregori, J., Pollyea, D. A., et al. (2019) · Blood

Acute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism

Cited by 158

Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5′ Pause Release, Termination, and Transcription Elongation Rate

Sheridan, R. M., Fong, N., D’Alessandro, A., & Bentley, D. L. (2019) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 123

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

Stevens, B. M., Khan, N., D’Alessandro, A., Nemkov, T., Winters, A., Jones, C. L., Zhang, W., Pollyea, D. A., & Jordan, C. T. (2018) · Nature Communications

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 78

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Giordano, A. M. S., Luciani, M., Gatto, F., Abou Alezz, M., Beghè, C., Della Volpe, L., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., et al. (2022) · Journal of Experimental Medicine

interferon and immune responsesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 76

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

Lesbats, J., Brillac, A., Reisz, J. A., Mukherjee, P., Lhuissier, C., Fernández-Monreal, M., Dupuy, J.-W., Sequeira, A., Tioli, G., De La Calle Arregui, C., et al. (2025) · Nature

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 74

Metabolic alterations mediated by STAT3 promotes drug persistence in CML

Patel, S. B., Nemkov, T., Stefanoni, D., Benavides, G. A., Bassal, M. A., Crown, B. L., Matkins, V. R., Camacho, V., Kuznetsova, V., Hoang, A. T., et al. (2021) · Leukemia

Chronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia Research

Cited by 56

CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer

Joshi, M., Kim, J., D’Alessandro, A., Monk, E., Bruce, K., Elajaili, H., Nozik-Grayck, E., Goodspeed, A., Costello, J. C., & Schlaepfer, I. R. (2020) · Cancers

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 54

Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis

Ionescu, R.-B., Nicaise, A. M., Reisz, J. A., Williams, E. C., Prasad, P., Willis, C. M., Simões-Abade, M. B. C., Sbarro, L., Dzieciatkowska, M., Stephenson, D., et al. (2024) · Cell Stem Cell

Multiple Sclerosis Research StudiesTelomeres, Telomerase, and Senescence

Cited by 34