Orr, Miranda E.

Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

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Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial

Gonzales, M. M., Garbarino, V. R., Kautz, T. F., Palavicini, J. P., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J. J., Zare, H., Xu, P., Zhang, B., et al. (2023) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 334

Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

Orr, M., Gonzales, M., Garbarino, V., Kautz, T., Palavicini, J., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J., Zare, H., Xu, P., et al. (2023) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 319

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

Cited by 203

Autophagic/lysosomal dysfunction in Alzheimer’s disease

Orr, M. E., & Oddo, S. (2013) · Alzheimer's Research & Therapy

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 199

Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceAlzheimer's disease research and treatments

Cited by 169

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Xu, P., Wang, M., Song, W.-M., Wang, Q., Yuan, G.-C., Sudmant, P. H., Zare, H., Tu, Z., Orr, M. E., & Zhang, B. (2022) · Molecular Neurodegeneration

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

Ramirez, P., Zuniga, G., Sun, W., Beckmann, A., Ochoa, E., DeVos, S. L., Hyman, B., Chiu, G., Roy, E. R., Cao, W., et al. (2022) · Progress in Neurobiology

Alzheimer's disease research and treatmentsChromosomal and Genetic Variations

Cited by 79

Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling

Walker, J. M., Kazempour Dehkordi, S., Fracassi, A., Vanschoiack, A., Pavenko, A., Taglialatela, G., Woltjer, R., Richardson, T. E., Zare, H., & Orr, M. E. (2022) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 59

Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease

Garbarino, V. R., Palavicini, J. P., Melendez, J., Barthelemy, N. R., He, Y., Kautz, T. F., Lopez-Cruzan, M., Mathews, J. J., Xu, P., Zhang, B., et al. (2025) · Neurotherapeutics

Alzheimer's disease research and treatmentsTelomeres, Telomerase, and Senescence

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