Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

Orr, Miranda; Gonzales, Mitzi; Garbarino, Valentina; Kautz, Tiffany; Palavicini, Juan; Lopez-Cruzan, Marisa; Dehkordi, Shiva Kazempour; Mathews, Julia; Zare, Habil; Xu, Peng; Zhang, Bin; Franklin, Crystal; Habes, Mohamad; Craft, Suzanne; Petersen, Ronald; Tchkonia, Tamara; Kirkland, James; Salardini, Arash; Seshadri, Sudha; Musi, Nicolas

doi:10.21203/rs.3.rs-2809973/v1

PreprintCited by 335Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchTelomeres, Telomerase, and Senescence

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Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

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Orr, Miranda, Gonzales, Mitzi, Garbarino, Valentina, Kautz, Tiffany, Palavicini, Juan, Lopez-Cruzan, Marisa, Dehkordi, Shiva Kazempour, Mathews, Julia, Zare, Habil, Xu, Peng, Zhang, Bin, Franklin, Crystal, Habes, Mohamad, Craft, Suzanne, Petersen, Ronald, Tchkonia, Tamara, Kirkland, James, Salardini, Arash, Seshadri, Sudha, Musi, Nicolas·2023·Nature Medicine

DOI 10.21203/rs.3.rs-2809973/v1PMC PMC10875739

Preprint — published as 10.1038/s41591-023-02543-w · Paper page

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Abstract

Cellular senescence has been identified as a pathological mechanism linked to tau and amyloid beta (Aβ) accumulation in mouse models of Alzheimer's disease (AD). Clearance of senescent cells using the senolytic compounds dasatinib (D) and quercetin (Q) reduced neuropathological burden and improved clinically relevant outcomes in the mice. Herein, we conducted a vanguard open-label clinical trial of senolytic therapy for AD with the primary aim of evaluating central nervous system (CNS) penetrance, as well as exploratory data collection relevant to safety, feasibility, and efficacy. Participants with early-stage symptomatic AD were enrolled in an open-label, 12-week pilot study of intermittent orally-delivered D+Q. CNS penetrance was assessed by evaluating drug levels in cerebrospinal fluid (CSF) using high performance liquid chromatography with tandem mass spectrometry. Safety was continuously monitored with adverse event reporting, vitals, and laboratory work. Cognition, neuroimaging, and plasma and CSF biomarkers were assessed at baseline and post-treatment. Five participants (mean age: 76±5 years; 40% female) completed the trial. The treatment increased D and Q levels in the blood of all participants ranging from 12.7 to 73.5 ng/ml for D and 3.29-26.30 ng/ml for Q. D levels were detected in the CSF of four participants ranging from 0.281 to 0.536 ng/ml (t(4)=3.123, p=0.035); Q was not detected. Treatment was well-tolerated with no early discontinuation and six mild to moderate adverse events occurring across the study. Cognitive and neuroimaging endpoints did not significantly differ from baseline to post-treatment. CNS levels of IL-6 and GFAP increased from baseline to post-treatment (t(4)=3.913, p=008 and t(4)=3.354, p=0.028, respectively) concomitant with decreased levels of several cytokines and chemokines associated with senescence, and a trend toward higher levels of Aβ42 (t(4)=-2.338, p=0.079). Collectively the data indicate the CNS penetrance of D and provide preliminary support for the safety, tolerability, and feasibility of the intervention and suggest that astrocytes and Aβ may be particularly responsive to the treatment. While early results are promising, fully powered, placebo-controlled studies are needed to evaluate the potential of AD modification with the novel approach of targeting cellular senescence.

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The role of cellular senescence in neurodegenerative diseases
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Cellular senescence, DNA damage, and neuroinflammation in the aging brain
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Adipose tissue as a linchpin of organismal ageing
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Inflammation and aging-related disease: A transdisciplinary inflammaging framework
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Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
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Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
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SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights
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Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
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Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
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A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease
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“14,27,28 To date, four human studies administering DQ as a combination senolytic therapy have been completed in various populations, including idiopathic pulmonary ﬁ brosis, 29 diabetic kidney disease, 30 age-related osteoporosis, 31 and Alzheimer ’ s disease.”
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Current senolytics: Mode of action, efficacy and limitations, and their future
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Cellular senescence in brain aging and cognitive decline
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Therapeutic targeting of senescent cells in the CNS
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Emerging epigenetic insights into aging mechanisms and interventions
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Frailty Trajectories Preceding Dementia in the US and UK
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Cellular senescence in Alzheimer’s disease: from physiology to pathology
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Senescent-like microglia limit remyelination through the senescence associated secretory phenotype
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The Role of Glial Cell Senescence in Alzheimer's Disease
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A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
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Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cognitive Impairment
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Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases
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Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging
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Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics
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Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial
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Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy
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Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans
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Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
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Uremic Toxins, CKD, and Cognitive Dysfunction
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Aging, cellular senescence and Parkinson's disease
Ma, Y., Erb, M. L., & Moore, D. J. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x251316552 · Cited by 48
Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease
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Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice
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Focus on senescence: Clinical significance and practical applications
Boccardi, V., Orr, M. E., Polidori, M. C., Ruggiero, C., & Mecocci, P. (2024) · Journal of Internal Medicine · doi:10.1111/joim.13775 · Cited by 40
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Geroscience
Kritchevsky, S. B., & Cummings, S. R. (2025) · JAMA · doi:10.1001/jama.2025.11289 · Cited by 40
Frailty for neurologists: perspectives on how frailty influences care planning
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Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle
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Latest Perspectives on Alzheimer’s Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems
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Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
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Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventions
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Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep
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Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies
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Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19
Owens, C. D., Pinto, C. B., Detwiler, S., Olay, L., Pinaffi‐Langley, A. C. D. C., Mukli, P., Péterfi, A., Szarvas, Z., James, J. A., Galván, V., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae080 · Cited by 36
The 2023 yearbook of Neurorestoratology
Huang, H., Bach, J. R., Sharma, H. S., Chen, L., Wu, P., Sarnowska, A., Otom, A. H., Xue, M., Saberi, H., He, X., et al. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100136 · Cited by 33
Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets
Nisar, A., Khan, S., Li, W., Hu, L., Samarawickrama, P. N., Gold, N. M., Zi, M., Mehmood, S. A., Miao, J., & He, Y. (2024) · MedComm · doi:10.1002/mco2.786 · Cited by 33
Hallmarks of aging and Alzheimer’s Disease pathogenesis: Paving the route for new therapeutic targets
Bellelli, F., Angioni, D., Arosio, B., Vellas, B. J., & Barreto, P. D. S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102699 · Cited by 33
Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients
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Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics
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Chronic social stress induces p16-mediated senescent cell accumulation in mice
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Anti-senescence therapies: a new concept to address cardiovascular disease
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Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
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Targeting DNA damage in ageing: towards supercharging DNA repair
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Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration
Trisal, A., & Singh, A. K. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01493-2 · Cited by 29
Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities
Hudson, H. R., Sun, X., & Orr, M. E. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00519 · Cited by 28
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Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Zhang, G., Samarawickrama, P. N., Gui, L., Ma, Y., Cao, M., Zhu, H., Li, W., Yang, H., Li, K., Yang, Y., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0065 · Cited by 27
A Critical Appraisal of the Utility of Targeting Therapy-Induced Senescence for Cancer Treatment
Saleh, T., Greenberg, E. F., Faber, A. C., Harada, H., & Gewirtz, D. A. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2219 · Cited by 27
Targeting vascular senescence in cardiovascular disease with aging
Hall, S. A., & Lesniewski, L. A. (2024) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.45 · Cited by 25
Trajectories of cardiovascular ageing—from molecular mechanisms to clinical implementation
Ministrini, S., Wenzl, F. A., Lüscher, T. F., & Camici, G. G. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae178 · Cited by 25
Cellular Senescence Is a Central Driver of Cognitive Disparities in Aging
Baier, M. P., Ranjit, R., Owen, D. B., Wilson, J. L., Stiles, M. A., Masingale, A. M., Thomas, Z., Bredegaard, A., Sherry, D. M., & Logan, S. (2025) · Aging Cell · doi:10.1111/acel.70041 · Cited by 25
A new clinical age of aging research
Zhang, Z., Yang, R., Zi, Z., & Liu, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.08.004 · Cited by 25
Dasatinib and Quercetin Limit Gingival Senescence, Inflammation, and Bone Loss
Rattanaprukskul, K., Xia, X.-J., Hysa, M., Jiang, M., Hung, M., Suslavich, S. F., & Sahingur, S. E. (2025) · Journal of Dental Research · doi:10.1177/00220345241299789 · Cited by 24
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Suda, M., Chaib, S., Prata, L. G. P. L., Zhu, Y. Z., Tripathi, U., Paul, K. H., Palmer, A. K., Pirtskhalava, T., Kulshreshtha, V., Inman, C. L., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.009 · Cited by 24
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Cellular senescence and frailty: a comprehensive insight into the causal links
Marcozzi, S., Bigossi, G., Giuliani, M. E., Giacconi, R., Piacenza, F., Cardelli, M., Brunetti, D., Segala, A., Valerio, A., Nisoli, E., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00960-w · Cited by 24
Fyn Kinase in Alzheimer’s Disease: Unraveling Molecular Mechanisms and Therapeutic Implications
Meur, S., & Karati, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04286-2 · Cited by 24
The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging
Lavarti, R., Alvarez-Diaz, T., Marti, K., Kar, P., & Raju, R. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102760 · Cited by 21
Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging
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Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications
Chen, Z., Mao, Z., Tang, W., Shi, Y., Liu, J., & You, Y. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00517-1 · Cited by 27
Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination?
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Quercetin as a Multi‐Target Natural Therapeutic in Aging‐Related Diseases: Systemic Molecular and Cellular Mechanisms
Zhou, S., Qingman, X., Zhang, W., Zhang, D., & Liu, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.70078 · Cited by 20
Alzheimer Combination Therapies: Overview and Scenarios
Cummings, J. L., Burstein, A. H., & Fillit, H. M. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100328 · Cited by 20
Cellular senescence of granulosa cells in the pathogenesis of polycystic ovary syndrome
Tanaka, T., Urata, Y., Harada, M., Kunitomi, C., Kusamoto, A., Koike, H., Xu, Z., Sakaguchi, N., Tsuchida, C., Komura, A., et al. (2024) · Molecular Human Reproduction · doi:10.1093/molehr/gaae015 · Cited by 20
Network pharmacology and molecular docking approach to elucidate potential phytocompounds, targets, and mechanisms of Glycyrrhiza glabra in the alleviation of cellular senescence
Sharma, R., & Bala, E. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100579 · Cited by 20
Senolytic Prodrugs: A Promising Approach to Enhancing Senescence‐Targeting Intervention
Chang, M., Dong, Y., Cruickshank‐Taylor, A. B., Gnawali, G. R., Bi, F., & Wang, W. (2024) · ChemBioChem · doi:10.1002/cbic.202400355 · Cited by 20
Cellular senescence: A novel therapeutic target for central nervous system diseases
Lei, S.-Y., Qu, Y., Yang, Y.-Q., Liu, J., Zhang, Y.-F., Zhou, S., He, Q., Jin, H., Yang, Y., & Guo, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117311 · Cited by 20
Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke
Huang, Z., Xu, P., Hess, D. C., & Zhang, Q. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00457-2 · Cited by 20
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Evaluation of exploratory fluid biomarkers from a phase 1 senolytic trial in mild Alzheimer's disease
Garbarino, V. R., Palavicini, J. P., Melendez, J., Barthelemy, N. R., He, Y., Kautz, T. F., Lopez-Cruzan, M., Mathews, J. J., Xu, P., Zhang, B., et al. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00591 · Cited by 26
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From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease
Hayashide, L. D. S., Pessoa, B., Dias, G. R., Pontes, B., Pinto, R. S., & Diniz, L. P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70361 · Cited by 19
Senescence, Aging and Disease Throughout the Gastrointestinal System
Ferreira-González, S., Matsumoto, T., Hara, E., & Forbes, S. J. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.06.010 · Cited by 18
p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression and Progression That Can Be Reversed by Senolytic Therapy
Zhou, L., DeMarco, K. D., Murphy, K. C., Wu, Z., Li, J., Johnson, C., Liu, B., Giwa, H. K., Ma, B., Bhalerao, N., et al. (2025) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-1212 · Cited by 18
Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases
Hugo, C., Asante, I., Sadybekov, A., Katritch, V., & Yassine, H. N. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2024.0794 · Cited by 18
The senotherapeutic potential of phytochemicals for age-related intestinal disease
Costa, C. M., Pedrosa, S. S., Kirkland, J. L., Reis, F., & Madureira, A. R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102619 · Cited by 18
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Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan
Fetarayani, D., Kahdina, M., Waitupu, A., Pratiwi, L., Ningtyas, M. C., Adytia, G. J., & Sutanto, H. (2025) · Medical Sciences · doi:10.3390/medsci13030100 · Cited by 17
Senotherapeutics for Brain Aging Management
Saliev, T. M., & Singh, P. B. (2025) · Neurology International · doi:10.3390/neurolint17120204 · Cited by 16
Overcoming the blood‒brain barrier: nanomedicine strategies for targeted delivery and multimodal therapy in Alzheimer's disease
Li, J., Guo, L., Cai, W., Mei, J., Liu, J., & Liu, Y. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2645830 · Cited by 16
Senescent T Cells in Age-Related Diseases
Yu, P.-J., Zhou, M. L., Liu, Y., & Du, J. (2024) · Aging and Disease · doi:10.14336/ad.2024.0219 · Cited by 16
Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline
Basurco, L., Abellanas, M. A., Purnapatre, M., Antonello, P., & Schwartz, M. (2024) · Neuron · doi:10.1016/j.neuron.2024.12.004 · Cited by 16
Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line
de Godoy, M. C. X., Macedo, J. A., & Gambero, A. (2024) · Pharmaceuticals · doi:10.3390/ph17010070 · Cited by 16
Translating cellular senescence research into clinical practice for metabolic disease
Chaib, S., Palmer, A. K., Wyles, S. P., Musi, N., Kirkland, J. L., & Tchkonia, T. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01187-9 · Cited by 15
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Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions
Shafqat, A., Masters, M. C., Tripathi, U., Tchkonia, T., Kirkland, J. L., & Hashmi, S. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102400 · Cited by 15
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Addition of Polyphenols to Drugs: The Potential of Controlling “Inflammaging” and Fibrosis in Human Senescent Lung Fibroblasts In Vitro
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Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203
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Self-citation

Authors: Orr, M., Gonzales, M., Garbarino, V., Kautz, T., Palavicini, J., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J., Zare, H., Xu, P., Zhang, B., Franklin, C., Habes, M., Craft, S., Petersen, R., Tchkonia, T., Kirkland, J., Salardini, A., Seshadri, S., & Musi, N.
Affiliations: W. G. (Bill) Hefner VA Medical Center (US)
The University of Texas at San Antonio Health Science Center (US)
University of Texas Health Science Center
Icahn School of Medicine at Mount Sinai (US)
Wake Forest University Health Sciences (US)
Mayo Clinic (US)
Mayo Clinic
Boston University (US)
Cedars-Sinai Medical Center (US)
Corresponding author: Orr, Miranda
Gonzales, Mitzi
ORCID: Orr, Miranda
Gonzales, Mitzi
Garbarino, Valentina
Kautz, Tiffany
Palavicini, Juan
Lopez-Cruzan, Marisa
Dehkordi, Shiva Kazempour
Zare, Habil
Xu, Peng
Zhang, Bin
Franklin, Crystal
Habes, Mohamad
Craft, Suzanne
Petersen, Ronald
Tchkonia, Tamara
Kirkland, James
Salardini, Arash
Seshadri, Sudha
Musi, Nicolas
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2023-04-24
Volume: 29
Issue: 10
Pages: 2481-2488
ISSN: 1078-8956 (ISSN-L)
DOI: 10.21203/rs.3.rs-2809973/v1
PMC: PMC10875739
OpenAlex: W4386499275
Cited by: 319
References: 64
Citations by year: 2026: 100 · 2025: 116 · 2024: 82 · 2023: 21
FWCI: 56.36
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Nature Medicine (publishedVersion)
Research Square (acceptedVersion, cc-by)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
PubMed Central (submittedVersion, cc-by)
ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
Funders: Hevolution Foundation
U.S. Department of Health and Human Services (TR002647, RF1AG059421, T32-AG021890, P30 AG062677, R01AG068293, R37AG13925, U01AG22307, R01AG080821, UF1 NS125417, R21NS125171, U19AG024904, R01AG069690, P30 AG066546, U54AG07594, R33AG061456, U01 AG046170, 1R01AG065301, R01AG054076, R01NS017950, P01AG062413, P30-AG013319, R01AG077472, R01AG068030, R01AG075684, R01AG033193, U01 AG006786, U24AG059624, PG30AG044271, U19NS115388, P30AG044271, R01AG066524, 1R01AG0665241A, P30AG072947, R01AG057896, U24 AG057437, 1RF1AG063507, RF1NS112391)
U.S. Department of Veterans Affairs (I01 BX005717, P30AG013319)
Alzheimer's Association (PTC REG-20-651687)
American Federation for Aging Research
Alzheimer's Drug Discovery Foundation (AG059421, GC-201908-2019443)
Cure Alzheimer's Fund
McGill University
GHR Foundation
Noaber Foundation
National Heart and Lung Institute (R01HL105756)
National Institutes of Health (4r01ag065301-03, TL1TR002647)
University of Texas Health Science Center at San Antonio (TR002647)
National Institute on Aging (R24AG073199, 1R01AG0665241A, RF1AG065301, U01AG22307, AG054076, U01AG046170, R01AG066524, R01AG069690, U01AG006786, R37 AG13925, R01AG068030, U54AG07594, R01AG057896, R01AG054076, R01AG065839, R01AG013925, 1R01AG065301, R01 AG065301, AG059421, PG30AG044271, RF1AG063507, R01AG033193, T32AG021890, RF1AG059421, R33AG061456, P30AG013319, U01AG022307, R37AG013925, R01AG080821, R01AG077472, U24AG057437, U19AG024904, U24AG059624, U54AG079754, P01AG062413, P30AG062677, R01AG068293, P30AG044271, P30AG072947, R01AG075684, P30AG066546)
National Heart, Lung, and Blood Institute (R01HL105756)
National Institute of Neurological Disorders and Stroke (R21NS125171, U19NS115388, RF1NS112391, UF1NS125417, R01NS017950)
National Center for Advancing Translational Sciences (TR002647)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: senolytic therapy, Alzheimer's disease, cellular senescence, dasatinib, quercetin, oral drug delivery, CNS penetration, cerebrospinal fluid drug concentration, drug safety and tolerability, interleukin-6, glial fibrillary acidic protein, amyloid-beta 42, aging biomarkers, early Alzheimer's disease

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Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

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