Bignell, Elaine

Tackling the emerging threat of antifungal resistance to human health

Fisher, M. C., Alastruey-Izquierdo, A., Berman, J., Bicanic, T., Bignell, E. M., Bowyer, P., Bromley, M., Brüggemann, R., Garber, G., Cornely, O. A., et al. (2022) · Nature Reviews Microbiology

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 1,179

Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence

Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H. N., Haynes, K., & Haas, H. (2004) · The Journal of Experimental Medicine

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 493

Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection

Schrettl, M., Bignell, E., Kragl, C., Sabiha, Y., Loss, O., Eisendle, M., Wallner, A., Arst, H. N., Haynes, K., & Haas, H. (2007) · PLoS Pathogens

Microbial Natural Products and BiosynthesisFungal and yeast genetics research

Cited by 405

Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA

Soriani, F. M., Malavazi, I., Da Silva Ferreira, M. E., Savoldi, M., Von Zeska Kress, M. R., De Souza Goldman, M. H., Loss, O., Bignell, E., & Goldman, G. H. (2008) · Molecular Microbiology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 168

The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

Bertuzzi, M., Schrettl, M., Alcazar-Fuoli, L., Cairns, T. C., Muñoz, A., Walker, L. A., Herbst, S., Safari, M., Cheverton, A. M., Chen, D., et al. (2014) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 158

The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen

Krappmann, S., Bignell, E. M., Reichard, U., Rogers, T., Haynes, K., & Braus, G. H. (2004) · Molecular Microbiology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 133

Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus

Yasmin, S., Alcazar-Fuoli, L., Gründlinger, M., Puempel, T., Cairns, T., Blatzer, M., Lopez, J. F., Grimalt, J. O., Bignell, E., & Haas, H. (2012) · Proceedings of the National Academy of Sciences

Microbial Natural Products and BiosynthesisFungal and yeast genetics research

Cited by 126

Inactivation of Transcription Factor Gene ACE2 in the Fungal Pathogen Candida glabrata Results in Hypervirulence

Kamran, M., Calcagno, A.-M., Findon, H., Bignell, E., Jones, M. D., Warn, P., Hopkins, P., Denning, D. W., Butler, G., Rogers, T., et al. (2004) · Eukaryotic Cell

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 75

Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease

Bertuzzi, M., Hayes, G., Icheoku, U., Van Rhijn, N., Denning, D., Osherov, N., & Bignell, E. (2018) · Journal of Fungi

Antifungal resistance and susceptibilityAsthma and respiratory diseases

Cited by 64

The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans

Han, K., Chun, Y., De Castro Pimentel Figueiredo, B., Soriani, F. M., Savoldi, M., Almeida, A., Rodrigues, F., Cairns, C. T., Bignell, E., Tobal, J. M., et al. (2010) · Molecular Microbiology

Enzyme function and inhibitionFungal and yeast genetics research

Cited by 30

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

Rhijn, N. V., Zhao, C., Al-Furaji, N., Storer, I., Valero, C., Gago, S., Chown, H., Baldin, C., Fortune-Grant, R., Shuraym, H. B., et al. (2023) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 30

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

van Rhijn, N., Zhao, C., Al-Furaiji, N., Storer, I. S. R., Valero, C., Gago, S., Chown, H., Baldin, C., Grant, R.-F., Bin Shuraym, H., et al. (2024) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 30

Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?

Amich, J., & Bignell, E. (2016) · Current Opinion in Microbiology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 26

Functional characterization of the Aspergillus fumigatus PHO80 homologue

de Gouvêa, P. F., Soriani, F. M., Malavazi, I., Savoldi, M., Goldman, M. H. D. S., Loss, O., Bignell, E., da Silva Ferreira, M. E., & Goldman, G. H. (2008) · Fungal Genetics and Biology

Fungal and yeast genetics researchPlant nutrient uptake and metabolism

Cited by 21

Conservation in Aspergillus fumigatus of pH‐signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery

Bignell, E. M. (2012) · Annals of the New York Academy of Sciences

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 6