Tyrrell, Jessica

Using human genetics to understand the disease impacts of testosterone in men and women

The Endometrial Cancer Association Consortium, Ruth, K. S., Day, F. R., Tyrrell, J., Thompson, D. J., Wood, A. R., Mahajan, A., Beaumont, R. N., Wittemans, L., Martin, S., et al. (2020) · Nature Medicine

Hormonal and reproductive studiesGenetic Associations and Epidemiology

Cited by 720

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones, S. E., Lane, J. M., Wood, A. R., van Hees, V. T., Tyrrell, J., Beaumont, R. N., Jeffries, A. R., Dashti, H. S., Hillsdon, M., Ruth, K. S., et al. (2019) · Nature Communications

Circadian rhythm and melatoninGenetic Associations and Epidemiology

Cited by 691

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Dashti, H. S., Jones, S. E., Wood, A. R., Lane, J. M., van Hees, V. T., Wang, H., Rhodes, J. A., Song, Y., Patel, K., Anderson, S. G., et al. (2018) · Nature Communications

Sleep and related disordersGenetic Associations and Epidemiology

Cited by 614

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci

Jones, S. E., Tyrrell, J., Wood, A. R., Beaumont, R. N., Ruth, K. S., Tuke, M. A., Yaghootkar, H., Hu, Y., Teder-Laving, M., Hayward, C., et al. (2016) · PLOS Genetics

Circadian rhythm and melatoninGenetic Associations and Epidemiology

Cited by 388

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank

Tyrrell, J., Jones, S. E., Beaumont, R., Astley, C. M., Lovell, R., Yaghootkar, H., Tuke, M., Ruth, K. S., Freathy, R. M., Hirschhorn, J. N., et al. (2016) · BMJ

Genetic Associations and EpidemiologyIntergenerational and Educational Inequality Studies

Cited by 372

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

Jones, S. E., van Hees, V. T., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., van der Spek, A., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2019) · Nature Communications

Sleep and related disordersGenetic Associations and Epidemiology

Cited by 300

Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., et al. (2016) · JAMA

Birth, Development, and HealthGestational Diabetes Research and Management

Cited by 284

Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001–2010

Tyrrell, J., Melzer, D., Henley, W., Galloway, T. S., & Osborne, N. J. (2013) · Environment International

Heavy Metal Exposure and ToxicityEffects and risks of endocrine disrupting chemicals

Cited by 226

Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting

Wright, C. F., West, B., Tuke, M., Jones, S. E., Patel, K., Laver, T. W., Beaumont, R. N., Tyrrell, J., Wood, A. R., Frayling, T. M., et al. (2019) · The American Journal of Human Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 212

Genetic predictors of participation in optional components of UK Biobank

Tyrrell, J., Zheng, J., Beaumont, R., Hinton, K., Richardson, T. G., Wood, A. R., Davey Smith, G., Frayling, T. M., & Tilling, K. (2021) · Nature Communications

Genetic Associations and EpidemiologyEthics in Clinical Research

Cited by 162

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

Frayling, T. M., Beaumont, R. N., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J., Sharp, S., et al. (2018) · Cell Reports

Fibroblast Growth Factor ResearchGenetic Associations and Epidemiology

Cited by 101

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively

The GIANT consortium, Wood, A. R., Tyrrell, J., Beaumont, R., Jones, S. E., Tuke, M. A., Ruth, K. S., Yaghootkar, H., Freathy, R. M., Murray, A., et al. (2016) · Diabetologia

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 74

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health

Ruth, K. S., Beaumont, R. N., Tyrrell, J., Jones, S. E., Tuke, M. A., Yaghootkar, H., Wood, A. R., Freathy, R. M., Weedon, M. N., Frayling, T. M., et al. (2016) · Human Reproduction

Hypothalamic control of reproductive hormonesReproductive Biology and Fertility

Cited by 70

Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health

O’Loughlin, J., Casanova, F., Jones, S. E., Hagenaars, S. P., Beaumont, R. N., Freathy, R. M., Watkins, E. R., Vetter, C., Rutter, M. K., Cain, S. W., et al. (2021) · Molecular Psychiatry

Circadian rhythm and melatoninSleep and related disorders

Cited by 44

Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

Martin, S., Tyrrell, J., Thomas, E. L., Bown, M. J., Wood, A. R., Beaumont, R. N., Tsoi, L. C., Stuart, P. E., Elder, J. T., Law, P., et al. (2022) · eLife

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 43

Assessing the analytical validity of SNP-chips for detecting very rare pathogenic variants: implications for direct-to-consumer genetic testing

Weedon, M. N., Jackson, L., Harrison, J. W., Ruth, K. S., Tyrrell, J., Hattersley, A. T., & Wright, C. F. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 19

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

Jones, S. E., Hees, V. T. V., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., der Spek, A. V., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

Sleep and related disordersGenetic Associations and Epidemiology

Cited by 14

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

Harlow, C. E., Gandawijaya, J., Bamford, R. A., Martin, E.-R., Wood, A. R., van der Most, P. J., Tanaka, T., Leonard, H. L., Etheridge, A. S., Innocenti, F., et al. (2022) · The American Journal of Human Genetics

Erythropoietin and Anemia TreatmentGenetic Associations and Epidemiology

Cited by 13