A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728 · see citing works

Genetic studies of body mass index yield new insights for obesity biology

Study, T. L. C., Locke, A. E., The ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The, G. L. G. C., The, I. C. B. P., The MAGIC Investigators, The MuTHER Consortium, et al. (2015) · Nature · doi:10.1038/nature14177 · Cited by 4,534 · see citing works

Untitled work

Willer (2013) · doi:10.1038/ng.2797 · Cited by 2,983 · see citing works

A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

the CARDIoGRAMplusC4D Consortium (2015) · Nature Genetics · doi:10.1038/ng.3396 · Cited by 2,447 · see citing works

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works

Defining the role of common variation in the genomic and biological architecture of adult human height

The Electronic Medical Records and Genomics (eMERGE) Consortium, Wood, A. R., The MIGen Consortium, The PAGE Consortium, Study, T. L. C., Esko, T., Yang, J., Vedantam, S., Pers, T. H., Gustafsson, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.3097 · Cited by 1,853 · see citing works

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works

New genetic loci link adipose and insulin biology to body fat distribution

The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580 · cited 4× · see citing works

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Mahajan, A., Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.2897 · Cited by 1,034 · see citing works

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works

Mapping the Genetic Architecture of Gene Expression in Human Liver

Schadt, E. E., Molony, C. M., Chudin, E., Hao, K., Yang, X., Lum, P. Y., Kasarskis, A., Zhang, B., Wang, S. S.-M., Suver, C., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060107 · Cited by 909 · see citing works

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2795 · Cited by 862 · see citing works

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott, R. A., Lagou, V., Welch, R., Wheeler, E., Montasser, M. E., Luan, J., Mägi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., et al. (2012) · Nature Genetics · doi:10.1038/ng.2385 · Cited by 817 · see citing works

Variation in<i>PCSK9</i>and<i>HMGCR</i>and Risk of Cardiovascular Disease and Diabetes

Ference, B. A., Robinson, J. G., Brook, R. D., Catapano, A. L., Chapman, M. J., Neff, D. R., Voros, S., Giugliano, R. P., Davey Smith, G., Fazio, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1604304 · Cited by 743 · see citing works

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738 · see citing works

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., Holmes, M. V., Engmann, J. E. L., Shah, T., Sofat, R., Stender, S., Johnson, P. C. D., Scott, R. A., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61183-1 · Cited by 680 · see citing works

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Lotta, L. A., Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., Sharp, S. J., Luan, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 587 · see citing works

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Chambers, J. C., Study, D. G. R. A. M.-A. (., Zhang, W., Sehmi, J., Li, X., Wass, M. N., van der Harst, P., Hólm, H., Sanna, S., Kavousi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.970 · Cited by 546 · see citing works

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545 · see citing works

A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects

Talukdar, S., Zhou, Y., Li, D., Rossulek, M., Dong, J., Somayaji, V., Weng, Y., Clark, R., Lanba, A., Owen, B. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.001 · Cited by 496 · see citing works

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

Mokry, L. E., Ross, S., Ahmad, O. S., Forgetta, V., Smith, G. D., Leong, A., Greenwood, C. M. T., Thanassoulis, G., & Richards, J. B. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001866 · Cited by 445 · see citing works

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426 · see citing works

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R., Umpleby, A. M., Thomas, E. L., Bell, J. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.4.910 · Cited by 423 · see citing works

Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis

Lotta, L. A., Sharp, S. J., Burgess, S., Perry, J. R. B., Stewart, I. D., Willems, S. M., Luan, J., Ardanaz, E., Arriola, L., Balkau, B., et al. (2016) · JAMA · doi:10.1001/jama.2016.14568 · Cited by 394 · see citing works

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Schmidt, A. F., Swerdlow, D. I., Holmes, M. V., Patel, R. S., Fairhurst-Hunter, Z., Lyall, D. M., Hartwig, F. P., Horta, B. L., Hyppönen, E., Power, C., et al. (2017) · The Lancet Diabetes &amp; Endocrinology · doi:10.1016/s2213-8587(16)30396-5 · Cited by 380 · see citing works

FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver

von Holstein-Rathlou, S., BonDurant, L. D., Peltekian, L., Naber, M. C., Yin, T. C., Claflin, K. E., Urizar, A. I., Madsen, A. N., Ratner, C., Holst, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.003 · Cited by 347 · see citing works

FGF21 Regulates Sweet and Alcohol Preference

Talukdar, S., Owen, B. M., Song, P., Hernandez, G., Zhang, Y., Zhou, Y., Scott, W. T., Paratala, B., Turner, T., Smith, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.008 · Cited by 342 · see citing works

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen, T. O., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.866 · Cited by 335 · see citing works

FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms

BonDurant, L. D., Ameka, M., Naber, M. C., Markan, K. R., Idiga, S. O., Acevedo, M. R., Walsh, S. A., Ornitz, D. M., & Potthoff, M. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.005 · Cited by 330 · see citing works

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

Berglund, E. D., Li, C. Y., Bina, H. A., Lynes, S. E., Michael, M. D., Shanafelt, A. B., Kharitonenkov, A., & Wasserman, D. H. (2009) · Endocrinology · doi:10.1210/en.2009-0221 · Cited by 297 · see citing works

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V. A., Cousminer, D. L., Dastani, Z., Drong, A., Esko, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10495 · Cited by 285 · see citing works

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3250 · Cited by 230 · see citing works

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

Tanaka, T., Ngwa, J. S., van Rooij, F. J., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.052183 · Cited by 226 · cited 2× · see citing works

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes

Yaghootkar, H., Scott, R. A., White, C. C., Zhang, W., Speliotes, E. K., Munroe, P. B., Ehret, G., Bis, J. C., Fox, C. S., Walker, M., et al. (2014) · Diabetes · doi:10.2337/db14-0318 · Cited by 218 · see citing works

FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans

Søberg, S., Sandholt, C. H., Jespersen, N. Z., Toft, U., Madsen, A. L., von Holstein-Rathlou, S., Grevengoed, T. J., Christensen, K. B., Bredie, W. L. P., Potthoff, M. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.009 · Cited by 216 · see citing works

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

Innocenti, F., Cooper, G. M., Stanaway, I. B., Gamazon, E. R., Smith, J. D., Mirkov, S., Ramı́rez, J., Liu, W., Lin, Y. S., Moloney, C., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002078 · Cited by 205 · see citing works

Novel locus including FGF21 is associated with dietary macronutrient intake

Chu, A. Y., Workalemahu, T., Paynter, N. P., Rose, L. M., Giulianini, F., Tanaka, T., Ngwa, J. S., Qi, Q., Curhan, G. C., Rimm, E. B., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt032 · Cited by 195 · see citing works

Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity

Scott, R. A., Fall, T., Pasko, D., Barker, A., Sharp, S. J., Arriola, L., Balkau, B., Barricarte, A., Barroso, I., Boeing, H., et al. (2014) · Diabetes · doi:10.2337/db14-0319 · Cited by 172 · see citing works

Common variants of FUT2 are associated with plasma vitamin B12 levels

Hazra, A., Kraft, P., Selhub, J., Giovannucci, E. L., Thomas, G. D., Hoover, R. N., Chanock, S. J., & Hunter, D. J. (2008) · Nature Genetics · doi:10.1038/ng.210 · Cited by 166 · see citing works

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohortPreprint

Greenawalt, D. M., Dobrin, R., Chudin, E., Hatoum, I. J., Suver, C., Beaulaurier, J., Zhang, B., Castro, V., Zhu, J., Sieberts, S. K., et al. (2011) · Genome Research · doi:10.1101/gr.112821.110 · Cited by 165 · see citing works

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., van der Most, P. J., Erzurumluoglu, A. M., O’Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09438 · Cited by 163 · see citing works

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

Yaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L. A., Beaumont, R. N., Campbell, A. I., Tuke, M. A., Hayward, C., et al. (2016) · Diabetes · doi:10.2337/db15-1671 · Cited by 152 · see citing works

Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates

Kim, A. M., Somayaji, V. R., Dong, J. Q., Rolph, T. P., Weng, Y., Chabot, J. R., Gropp, K. E., Talukdar, S., & Calle, R. A. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13023 · Cited by 145 · see citing works

Fibroblast growth factor 21 night watch: advances and uncertainties in the field

Kharitonenkov, A., & DiMarchi, R. D. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12580 · Cited by 97 · see citing works

FGF21 Mimetic Shows Therapeutic Promise

Reitman, M. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.014 · Cited by 47 · see citing works

Statins and type 2 diabetes: genetic studies on target

Frayling, T. M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61639-1 · Cited by 22 · see citing works

Erratum: Impact of genetically supported target selection on R&D productivity

Hurle, M. R., Nelson, M. R., Agarwal, P., & Cardon, L. R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.187 · Cited by 10 · see citing works

Blood Lipids and Type 2 Diabetes Risk: Can Genetics Help Untangle the Web?

Swerdlow, D. I., & Sattar, N. A. (2015) · Diabetes · doi:10.2337/db15-0458 · Cited by 9 · see citing works

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Warrington, N. M., Beaumont, R. N., Horikoshi, M., Day, F. R., Helgeland, Ø., Laurin, C., Bačelis, J., Peng, S., Hao, K., Feenstra, B., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0403-1 · Cited by 574 · see citing works

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial

Harrison, S. A., Ruane, P. J., Freilich, B. L., Neff, G., Patil, R., Behling, C. A., Hu, C., Fong, E., de Temple, B., Tillman, E. J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01425-3 · Cited by 368 · see citing works

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

Eslam, M., & George, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0212-0 · Cited by 310 · see citing works

Metabolic messengers: FGF21

Flippo, K. H., & Potthoff, M. J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00354-2 · Cited by 311 · see citing works

Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study

Budu‐Aggrey, A., Brumpton, B. M., Tyrrell, J., Watkins, S., Modalsli, E. H., Celis-Morales, C. A., Ferguson, L. D., Vie, G. Å., Palmer, T., Fritsche, L. G., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002739 · Cited by 266 · see citing works

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.008 · Cited by 166 · see citing works

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

Parisinos, C. A., Wilman, H. R., Thomas, E. L., Kelly, M., Nicholls, R. C., McGonigle, J., Neubauer, S., Hingorani, A. D., Patel, R. S., Hemingway, H., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.032 · Cited by 148 · see citing works

New developments in the biology of fibroblast growth factors

Ornitz, D. M., & Itoh, N. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1549 · Cited by 143 · see citing works

The FGF metabolic axis

Li, X. (2019) · Frontiers of Medicine · doi:10.1007/s11684-019-0711-y · Cited by 139 · see citing works

AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Kaufman, A., Abuqayyas, L., Denney, W. S., Tillman, E. J., & Rolph, T. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100057 · Cited by 131 · see citing works

Factors influencing the choice of beer: A review

Betancur, M. I. N., Motoki, K., Spence, C. J., & Velasco, C. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109367 · Cited by 131 · see citing works

Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

May-Wilson, S., Matoba, N., Wade, K. H., Hottenga, J., Concas, M. P., Mangino, M., Grzeszkowiak, E. J., Menni, C., Gasparini, P., Timpson, N. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30187-w · Cited by 114 · see citing works

FGF21 and the physiological regulation of macronutrient preference

Hill, C. M., Qualls-Creekmore, E., Berthoud, H.-R., Soto, P., Yu, S., McDougal, D. H., Münzberg, H., & Morrison, C. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa019 · Cited by 99 · see citing works

The role of FGF21 and its analogs on liver associated diseases

Falamarzi, K., Malekpour, M., Tafti, M. F., Azarpira, N., Behboodi, M., & Zarei, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.967375 · Cited by 94 · see citing works

FGF19 and FGF21 for the Treatment of NASH—Two Sides of the Same Coin? Differential and Overlapping Effects of FGF19 and FGF21 From Mice to Human

Henriksson, E., & Andersen, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601349 · Cited by 95 · see citing works

New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances

Hwang, L., Lin, C., Gharahkhani, P., Cuéllar-Partida, G., Ong, J., An, J., Gordon, S. D., Zhu, G., MacGregor, S., Lawlor, D. A., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz043 · Cited by 88 · see citing works

Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges

Martínez‐Garza, Ú., Torres‐Oteros, D., Yarritu, A., Marrero, P. F., Haro, D., & Relat, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194692 · Cited by 87 · see citing works

Factors affecting odour-induced taste enhancement

Spence, C. J. (2021) · Food Quality and Preference · doi:10.1016/j.foodqual.2021.104393 · Cited by 90 · see citing works

Circulating FGF21 Levels in Human Health and Metabolic Disease

Keuper, M., Häring, H., & Staiger, H. (2019) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-0879-2968 · Cited by 82 · see citing works

Neuroscience and the Criminal Justice System

Greely, H. T., & Farahany, N. A. (2018) · Annual Review of Criminology · doi:10.1146/annurev-criminol-011518-024433 · Cited by 77 · see citing works

Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?

Rohde, K., Schamarek, I., & Blüher, M. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0058 · Cited by 74 · see citing works

The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model

Spann, R. A., Morrison, C. D., & den Hartigh, L. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.802541 · Cited by 75 · see citing works

Mendelian randomization as a tool for causal inference in human nutrition and metabolism

Larsson, S. C. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000721 · Cited by 67 · see citing works

Pegbelfermin (BMS-986036): an investigational PEGylated fibroblast growth factor 21 analogue for the treatment of nonalcoholic steatohepatitis

Verzijl, C. R. C., van de Peppel, I. P., Struik, D., & Jonker, J. W. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1708898 · Cited by 67 · see citing works

Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application

Struik, D., Dommerholt, M. B., & Jonker, J. W. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000599 · Cited by 61 · see citing works

Genome-wide association study of breakfast skipping links clock regulation with food timing

Dashti, H. S., Merino, J., Lane, J. M., Song, Y., Smith, C. E., Tanaka, T., McKeown, N. M., Tucker, C., Sun, D., Bartz, T. M., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz076 · Cited by 61 · see citing works

FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system

Choi, M., Schneeberger, M., Fan, W., Bugde, A., Gautron, L., Vale, K., Hammer, R. E., Zhang, Y., Friedman, J. M., Mangelsdorf, D. J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.005 · Cited by 51 · see citing works

Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

Le, T. D. V., Fathi, P. A., Watters, A. B., Ellis, B. J., Besing, G.-L. K., Bozadjieva-Kramer, N., Perez, M. B., Sullivan, A. I., Rose, J. P., Baggio, L. L., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101718 · Cited by 48 · see citing works

Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite

von Holstein‐Rathlou, S., & Gillum, M. P. (2019) · The Journal of Physiology · doi:10.1113/jp277117 · Cited by 44 · see citing works

Enhancement effect of odor and multi‐sensory superposition on sweetness

Zhang, D., Lao, F., Pan, X. Y., Li, J., Yuan, L., Li, M., Cai, Y., & Wu, J. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13245 · Cited by 40 · see citing works

Non-pharmacological management options for MAFLD: a practical guide

Stefano, J. T., Duarte, S. M. B., Altikes, R. G., & de Oliveira, C. P. M. S. (2023) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188231160394 · Cited by 41 · see citing works

Do men and women really live in different taste worlds?

Spence, C. J. (2018) · Food Quality and Preference · doi:10.1016/j.foodqual.2018.12.002 · Cited by 38 · see citing works

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH

Larsson, S. C., Michaëlsson, K., Mola-Caminal, M., Höijer, J., & Mantzoros, C. S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155329 · Cited by 39 · see citing works

Perceptual learning in the chemical senses: A review

Spence, C. J. (2019) · Food Research International · doi:10.1016/j.foodres.2019.06.005 · Cited by 39 · see citing works

Fibroblast growth factor 21 is a hepatokine involved in MASLD progression

Gallego‐Durán, R., Ampuero, J., Maya‐Miles, D., Pastor‐Ramírez, H., Montero‐Vallejo, R., Rivera‐Esteban, J., Álvarez‐Amor, L., Pareja, M. J., Rico, M. C., Millán, R., et al. (2024) · United European Gastroenterology Journal · doi:10.1002/ueg2.12534 · Cited by 35 · see citing works

Emerging Structure–Function Paradigm of Endocrine FGFs in Metabolic Diseases

Luo, Y., Ye, S., Li, X., & Lu, W. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.002 · Cited by 36 · see citing works

Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis

Khan, M. S. H., Spann, R. A., Münzberg, H., Yu, S., Albaugh, V. L., He, Y., Berthoud, H., & Morrison, C. D. (2021) · Nutrients · doi:10.3390/nu13114103 · Cited by 35 · see citing works

Fibroblast growth factor 21 as a potential master regulator in metabolic disorders

Velingkar, A., Vuree, S., Prabhakar, P. K., Kalashikam, R. R., Banerjee, A., & Kondeti, S. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2022 · Cited by 32 · see citing works

Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults

Naja, F., Itani, L., Hammoudeh, S. M., Manzoor, S., Abbas, N., Radwan, H. M., & Saber-Ayad, M. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.668901 · Cited by 30 · see citing works

Sonic Seasoning and Other Multisensory Influences on the Coffee Drinking Experience

Spence, C. J. (2021) · Frontiers in Computer Science · doi:10.3389/fcomp.2021.644054 · Cited by 29 · see citing works

Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus

Bayoumi, A., Elsayed, A., Han, S., Petta, S., Adams, L. A., Aller, R., Khan, A., García‐Monzón, C., Arias, M., Miele, L., et al. (2021) · Advanced Science · doi:10.1002/advs.202004168 · Cited by 26 · see citing works

Gene Lifestyle Interactions With Relation to Obesity, Cardiometabolic, and Cardiovascular Traits Among South Asians

Ahmad, S., Fatima, S. S., Rukh, G., & Smith, C. E. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00221 · Cited by 24 · see citing works

Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats

Tillman, E. J., Brock, W. J., & Rolph, T. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15725 · Cited by 22 · see citing works

Current understanding and controversies on the clinical implications of fibroblast growth factor 21

Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20 · see citing works

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

Tiwari, V., Jin, B., Sun, O., Gonzalez, E. D. J. L., Chen, M.-H., Wu, X., Shah, H., Zhang, A., Herman, M. A., Spracklen, C. N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01399-3 · Cited by 19 · see citing works

Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: Molecular links between the SNHG16 locus and catecholamine metabolism

Ho, M., Zhang, C., Moon, I., Wei, L., Coombes, B. J., Biernacka, J. M., Skime, M. K., Choi, D., Frye, M. A., Schmidt, K., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101534 · Cited by 20 · see citing works

Meal sugar-protein balance determines postprandial FGF21 response in humans

Ramne, S., Duizer, L., Nielsen, M. S., Jørgensen, N. R., Svenningsen, J. S., Grarup, N., Sjödin, A. M., Raben, A., & Gillum, M. P. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2023 · Cited by 20 · see citing works

Fibroblast growth factor 21: update on genetics and molecular biology

Barros, D. R., & Hegele, R. A. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000960 · Cited by 18 · see citing works

FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery

Patt, M., Karkossa, I., Krieg, L., Massier, L., Makki, K., Tabei, S., Karlas, T., Dietrich, A., Gericke, M. T., Stümvoll, M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105458 · Cited by 16 · see citing works

The Effect of FGF21 and Its Genetic Variants on Food and Drug Cravings, Adipokines and Metabolic Traits

Epperlein, S., Gebhardt, C., Rohde, K., Chakaroun, R., Patt, M., Schamarek, I., Kralisch, S., Heiker, J. T., Scholz, M. R., Stümvoll, M., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9040345 · Cited by 16 · see citing works

Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Larsson, S. C., & Gill, D. (2021) · Nutrients · doi:10.3390/nu13051504 · Cited by 16 · see citing works

Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population

Janzi, S., González-Padilla, E., Najafi, K., Ramne, S., Ahlqvist, E., Borné, Y., & Sonestedt, E. (2021) · Nutrients · doi:10.3390/nu13113954 · Cited by 14 · see citing works

FGF21 mediating the Sex-dependent Response to Dietary Macronutrients

Sauza, K. A. S., & Ryan, K. K. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae363 · Cited by 14 · see citing works

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

Harlow, C. E., Gandawijaya, J., Bamford, R. A., Martin, E.-R., Wood, A. R., van der Most, P. J., Tanaka, T., Leonard, H. L., Etheridge, A. S., Innocenti, F., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.08.004 · Cited by 13 · see citing works

The FGF-21 genetic variants rs838133 and rs838145 are associated with high salt intake in the Emirati population

Saber-Ayad, M. M., Hammoudeh, S. M., Radwan, H. M., Manzoor, S., Jabbar, H. A., Wardeh, R., Ashraf, A., Habib, P. T., Alsamman, A. M., & Hamoudi, R. (2020) · Journal of Advanced Research · doi:10.1016/j.jare.2020.05.020 · Cited by 11 · see citing works

3-Month post-operative increase in FGF21 is predictive of one-year weight loss after bariatric surgery

De Luca, A., Delaye, J.-B., Fauchier, G., Bourbao-Tournois, C., Champion, H., Bourdon, G., Dupont, J., Froment, P., Dufour, D., & Ducluzeau, P.-H. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06702-3 · Cited by 11 · see citing works

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs

Kibble, M., Khan, S. A., Ammad-ud-din, M., Bollepalli, S., Palviainen, T., Kaprio, J. A., Pietiläinen, K. H., & Ollikainen, M. (2020) · Royal Society Open Science · doi:10.1098/rsos.200872 · Cited by 10 · see citing works

Fibroblast growth factor 21 resistance is associated with body shape in patients with type 2 diabetes complicating hypertension

Gan, J., Duan, Z., Tang, L., Liu, Z., Tian, H., Wu, M., Bi, Y., Pan, X., Wang, W., Gao, X., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1168047 · Cited by 9 · see citing works

TAS1R2/TAS1R3 Single-Nucleotide Polymorphisms Affect Sweet Taste Receptor Activation by Sweeteners: The SWEET Project

Belloir, C., Jeannin, M., Karolkowski, A., & Briand, L. V. (2025) · Nutrients · doi:10.3390/nu17060949 · Cited by 9 · see citing works

Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity

Ruiz-Padilla, A. J., Morales-Hernandez, G., Ruíz‐Noa, Y., Alonso‐Castro, Á. J., Lazo-de-la-Vega-Monroy, M.-L., Preciado‐Puga, M. D. C., Rangel-Salazar, R., & Ibarra‐Reynoso, L. D. R. (2019) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2018-0546 · Cited by 9 · see citing works

Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans

Solomon, T. P. J., Carter, S., Haus, J. M., Karstoft, K., von Holstein‐Rathlou, S., Nielsen, M. S., & Gillum, M. P. (2022) · PeerJ · doi:10.7717/peerj.12755 · Cited by 10 · see citing works

A Systematic Review of the Effect of Gene–Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations

Bineid, M. M., Ventura, E. F., Samidoust, A., Radha, V., Anjana, R., Sudha, V., Walton, G. E., Mohan, V., & Vimaleswaran, K. (2024) · Nutrition reviews · doi:10.1093/nutrit/nuae115 · Cited by 10 · see citing works

Understanding the determinants of sweet taste liking in the African and East Asian ancestry groups in the U.S.–A study protocol

Cheung, M. M., Hubert, P. A., Reed, D. R., Pouget, E. R., Jiang, X., & Hwang, L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300071 · Cited by 7 · see citing works

The Interaction of Single Nucleotide Polymorphisms on Fibroblast Growth Factor 19 Superfamily Genes Is Associated With Alcohol Dependence-Related Aggression

Xu, J., Wu, F., Wang, F., Yang, F., Liu, M., Lou, M., Wu, L., Li, H., Lin, W., Fan, Y., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.695835 · Cited by 7 · see citing works

Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?

Nielsen, M. S., Ritz, C., Chenchar, A., Bredie, W. L. P., Gillum, M. P., & Sjödin, A. M. (2021) · Nutrients · doi:10.3390/nu13113840 · Cited by 7 · see citing works

Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

Ruth, K. S., Beaumont, R. N., Locke, J. M., Tyrrell, J., Crandall, C. J., Hawkes, G., Frayling, T. M., Prague, J., Patel, K. A., Wood, A. R., et al. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01658-w · Cited by 7 · see citing works

Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice

Pacheco-Bernal, I., Becerril-Pérez, F., Bustamante-Zepeda, M., González-Suárez, M., Olmedo-Suárez, M. Á., Hernández-Barrientos, L. R., del Carmen, A. A., Escalante‐Covarrubias, Q., Mendoza-Viveros, L., Lemus, E. H., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05364-3 · Cited by 6 · see citing works

Genetic risk for obesity and the effectiveness of the ChooseWell 365 workplace intervention to prevent weight gain and improve dietary choices

Dashti, H. S., Levy, D. E., Hivert, M., Alimenti, K., McCurley, J. L., Saxena, R., & Thorndike, A. N. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab303 · Cited by 6 · see citing works

Large-scale genome-wide association study of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traitsPreprint

May-Wilson, S., Matoba, N., Wade, K. H., Hottenga, J., Concas, M. P., Mangino, M., Grzeszkowiak, E. J., Menni, C., Gasparini, P., Timpson, N. J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.28.454120 · Cited by 6 · see citing works

Investigation of the Characteristics of Crimean Congo Hemorrhagic Fever Cases Reported in Afyonkarahisar Province

Korkmaz, D., Konya, P. Ş., & Demirtürk, N. (2022) · Turkish Journal of Parasitology · doi:10.4274/tpd.galenos.2022.14633 · Cited by 5 · see citing works

A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics

Rao, Z., Chen, Z., Bao, Y., Lu, Z., Tang, Y., Zhu, J., Ma, J., Dong, S., Shi, J., Sheng, S., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02402-9 · Cited by 5 · see citing works

Association of NAFLD with FGF21 Polygenic Hazard Score, and Its Interaction with Protein Intake Level in Korean Adults

Lee, H. J., Shon, J., & Park, Y. J. (2023) · Nutrients · doi:10.3390/nu15102385 · Cited by 5 · see citing works

Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans

Basolo, A., Hollstein, T., Shah, M. H., Walter, M. F., Krakoff, J. A., Votruba, S. B., & Piaggi, P. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab204 · Cited by 6 · see citing works

Plasma FGF21 Levels Are Not Associated with Weight Loss or Improvements in Metabolic Health Markers upon 12 Weeks of Energy Restriction: Secondary Analysis of an RCT

Gijbels, A., Schutte, S., Esser, D., Michielsen, C. C. J. R., Siebelink, E., Mars, M., Mensink, M., & Afman, L. A. (2022) · Nutrients · doi:10.3390/nu14235061 · Cited by 5 · see citing works

Perspectives on Multisensory Human-Food Interaction

Velasco, C., Obrist, M., Huisman, G., Nijholt, A., Spence, C., Motoki, K., & Narumi, T. (2022) · Frontiers research topics · doi:10.3389/978-2-88974-233-2 · Cited by 4 · see citing works

Sweet Taste Receptors’ Genetic Variability in Advanced Potential Targets of Obesity

Wagner, S., Fernández, L. P., Colmenarejo, G., Cruz-Gil, S., Espinosa‐Salinas, I., Molina, S., Crespo, M. C., Aguilar-Aguilar, E., Marcos-Pasero, H., de la Iglesia, R., et al. (2025) · Nutrients · doi:10.3390/nu17101712 · Cited by 3 · see citing works

Non-classical hormones from the fibroblast growth factor family

Gronskaia, S., Rusyaeva, N. V., Belaya, Z. E., & Mel'nichenko, G. A. (2024) · Problems of Endocrinology · doi:10.14341/probl13441 · Cited by 2 · see citing works

Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate DietsPreprint

Le, T. D. V., Fathi, P. A., Watters, A. B., Ellis, B. J., Bozadjieva-Kramer, N., Perez, M. B., Sullivan, A. I., Rose, J. P., Baggio, L. L., Koehler, J. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.03.522509 · Cited by 2 · see citing works

Understanding the Determinants of Sweet Liking in the African and East Asian Ancestry Groups in the U.S. – A Study ProtocolPreprint

Cheung, M. M., Hubert, P. A., Reed, D. R., Pouget, E. R., Jiang, X., & Hwang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3644422/v1 · Cited by 2 · see citing works

Fibroblast Growth Factor 21: Possible Role in Growth and Metabolic Development during Early Life, Nutritional Interactions and Biological Actions

Wali, J. A., Ramos-Nieves, J. M., Binia, A., & van der Beek, E. M. (2026) · Advances in Nutrition · doi:10.1016/j.advnut.2026.100713 · Cited by 1 · see citing works

Adipokine & klinische Bedeutung

Blüher, M. (2019) · Adipositas - Ursachen Folgeerkrankungen Therapie · doi:10.1055/a-0804-6353 · Cited by 1 · see citing works

Effect of plain versus sugar‐sweetened breakfast on energy balance and metabolic health: A secondary data analysis stratified by participant-defined sweet preferencePreprint

Carroll, H. A. (2020) · doi:10.31232/osf.io/68h3x · Cited by 1 · see citing works

Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus

Bayoumi, A. (2020) · The Sydney eScholarship Repository (The University of Sydney)

Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptomsPreprint

Ruth, K. S., Beaumont, R. N., Locke, J. M., Tyrrell, J., Crandall, C. J., Hawkes, G., Frayling, T. M., Prague, J., Patel, K. A., Wood, A. R., et al. (2022) · medRxiv · doi:10.1101/2022.05.25.22275501

FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic NeuronsPreprint

Choi, M., Schneeberger, M., Fan, W., Bugde, A., Gautron, L., Vale, K., Zhang, Y., Friedman, J. M., Mangelsdorf, D. J., & Kliewer, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.09.502667

Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk

Harlow, C. E., Patel, V. V., Waterworth, D. M., Wood, A. R., Beaumont, R. N., Ruth, K. S., Tyrrell, J., Oguro‐Ando, A., Chu, A. Y., & Frayling, T. M. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac215

Precision nutrition for cardiometabolic health: insights from human dietary intervention studies

Gijbels, A. (2023) · doi:10.18174/591161

Double knockout of FFAR4 and FGF21 aggravates metabolic disorders in mice

Wei, L., Ye, X., Cui, S., Li, D., & Zhu, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126553

The association between high-energy diets, sugar-sweetened beverages on the risk of depression in rural-urban adolescent studentsPreprint

Gu, L., Wang, X., & Tian, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3358807/v1

The FGF metabolic axis

Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00000-7

Community Series - Liver Fibrosis and MAFLD: from Molecular Aspects to Novel Pharmacological Strategies, Volume II

(2024) · Frontiers research topics · doi:10.3389/978-2-8325-4473-0

Genetic aspects of taste formation

Gumeniuk, O. I., Евгеньевич, Л. М., Евгеньевна, П. Т., Михайловна, Ч. Е., Chernenkov, Y. V., Groznova, O. S., & Глушаков, И. А. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-226-6-38-42

Additional file 1 of Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

Ruth, K. S., Beaumont, R. N., Locke, J. M., Tyrrell, J., Crandall, C. J., Hawkes, G., Frayling, T. M., Prague, J., Patel, K. A., Wood, A. R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24234146

Additional file 2 of Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

Ruth, K. S., Beaumont, R. N., Locke, J. M., Tyrrell, J., Crandall, C. J., Hawkes, G., Frayling, T. M., Prague, J., Patel, K. A., Wood, A. R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24234331

Salient cue reactivity and eating behaviours in ex-smokers, abstinent alcohol use disorder and obesityPreprint

Herlinger, K., Long, Y. Y., Nestor, L. J., Pannekoek, J. N., Lababidi, M. A., Ertl, N., Vanelli, F., Alabdulkader, S., Chhibbar, P., Guerrero, E., et al. (2026) · medRxiv · doi:10.64898/2026.03.13.26348339

Rôle des aminoacides ramifiés dans le déterminisme génétique de la résistance à l’insuline

Haydar, S. (2018) · theses.fr (ABES) · doi:10.70675/5c14c2c4z469bz40fazb55cz985ea78d6c2a

Explainable machine learning reveals the role of taste-related genetic variants in body mass index: a nutrigenetic perspective

Meral, G., Burkay, N., Avcı, A., Özkaya, M., Beyler, B., Acar, E. G. A., Ateşli, R., Eser, R., Yunus, M., & Coşkun, B. U. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1869879

Fibroblast growth factor 21 in metabolic dysfunction-associated steatotic liver disease and beyond: from bench to bedside

Leung, H.-K., Tan, G.-J., Wong, W., Khamis, F., Zain, S. M., & Chan, W. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2026.20

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressurePreprint

Frayling, T. M., Beaumont, R. N., Jones, S. E., Yaghootkar, H., Tuke, M. A., Ruth, K. S., Casanova, F., West, B., Locke, J. M., Sharp, S. A., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/214700 · Cited by 3 · see citing works

Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data

Ramne, S., García‐Ureña, M., Gillum, M. P., Ängquist, L. H., Hansen, T., Merino, J., & Grarup, N. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102049 · Cited by 11 · see citing works

Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer’s Disease

Larsson, S. C., & Gill, D. (2021) · Nutrients · doi:10.3390/nu13051504 · Cited by 16 · see citing works

Abstract 16199: The Carbohydrate- and Alcohol Intakes Associated FGF21 Genotype, Change in Alcohol Consumption, and Weight Change

Ma, H., Li, X. O., Zhou, T., Sun, D., Heianza, Y., & Qi, L. (2018) · Circulation

Genome-wide association study for circulating fibroblast growth factor 21 and 23

Chuang, G., Liu, P., Chyan, T., Huang, C.-H., Huang, Y., Lin, C.-H., Lin, J., Hsu, C., Tsai, R., Hsieh, M.-L., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-71569-8 · Cited by 14 · see citing works