Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Open accessAbstract
IMPORTANCE: Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain. OBJECTIVE: To test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight. DESIGN, SETTING, AND PARTICIPANTS: Mendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30,487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included. EXPOSURES: Genetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level. MAIN OUTCOME AND MEASURE: Offspring birth weight from 18 studies. RESULTS: Among the 30,487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P = .008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P = 7 × 10(-14)) and -4 g (95% CI, -6 to -2 g) per SBP-raising allele (P = 1×10(-5)), respectively. A 1-SD ( ≈ 4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD ( ≈ 7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD ( ≈ 10 mm Hg) genetically higher maternal SBP was associated with a 208-g lower offspring birth weight (95% CI, -394 to -21 g). For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions. CONCLUSIONS AND RELEVANCE: In this mendelian randomization study, genetically elevated maternal BMI and blood glucose levels were potentially causally associated with higher offspring birth weight, whereas genetically elevated maternal SBP was potentially causally related to lower birth weight. If replicated, these findings may have implications for counseling and managing pregnancies to avoid adverse weight-related birth outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
We found positive associations of maternal gestational fasting glucose with offspring birthweight in multivariable regression analyses pooled from European origin cohort studies with minimal adjustment for potential confounders.
“We found positive associations of maternal gestational fasting glucose with offspring birthweight in multivariable regression analyses pooled from European origin cohort studies with minimal adjustment for potential confounders.55”
From Triangulation in aetiological epidemiology (2017) · cites this paper as [55]
Positive fasting glucose-birthweight effects were also seen in the IV of glucose as an intermediate in an RCT and IV MR studies.
“Positive fasting glucose-birthweight effects were also seen in the IV of glucose as an intermediate in an RCT57 and IV MR studies.55”
From Triangulation in aetiological epidemiology (2017) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Davey Smith, G., & Ebrahim, S. (2003) · International Journal of Epidemiology · doi:10.1093/ije/dyg070 · Cited by 5,882 · see citing works
Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563 · see citing works
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618 · see citing works
Avoiding bias from weak instruments in Mendelian randomization studies
Burgess, S., Thompson, S. G., & CRP CHD Genetics Collaboration (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr036 · Cited by 3,952 · see citing works
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,527 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Fraser, A., Macdonald-Wallis, C., Tilling, K., Boyd, A., Golding, J., Davey Smith, G., Henderson, J., Macleod, J., Molloy, L., Ness, A., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dys066 · Cited by 2,494 · see citing works
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works
the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.2383 · Cited by 1,912 · see citing works
An atlas of genetic influences on human blood metabolites
The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Shin, S.-Y., Fauman, E. B., Petersen, A.-K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., et al. (2014) · Nature Genetics · doi:10.1038/ng.2982 · Cited by 1,515 · see citing works
The Generation R Study: design and cohort update 2017
Kooijman, M. N., Kruithof, C. J., van Duijn, C. M., Duijts, L., Franco, O. H., van IJzendoorn, M. H., de Jongste, J. C., Klaver, C. C. W., van der Lugt, A., Mackenbach, J. P., et al. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0224-9 · Cited by 1,221 · see citing works
The Danish National Birth Cohort - its background, structure and aim
Olsen, J., Melbye, M., Olsen, S. F., Sørensen, T. I. A., Aaby, P., Andersen, A. N., Taxbøl, D., Hansen, K. D., Juhl, M., Schow, T. B., et al. (2001) · Scandinavian Journal of Public Health · doi:10.1177/14034948010290040201 · Cited by 1,071 · see citing works
Vimaleswaran, K. S., Berry, D. J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L. T., Cooper, J. D., Dastani, Z., Li, R., Houston, D. K., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001383 · Cited by 1,046 · see citing works
The Generation R Study: design and cohort update 2010
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9516-7 · Cited by 1,027 · see citing works
Self-citationCohort profile: The Norwegian Mother and Child Cohort Study (MoBa)
Magnus, P. M., Irgens, L. M., Haug, K., Nystad, W., Skjærven, R., & Stoltenberg, C. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl170 · Cited by 1,027 · see citing works
Cohort profile: 1958 British birth cohort (National Child Development Study)
Power, C., & Elliott, J. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi183 · Cited by 978 · see citing works
The Hyperglycemia and Adverse Pregnancy Outcome Study
Catalano, P. M., McIntyre, H. D., Cruickshank, J. K., McCance, D. R., Dyer, A. R., Metzger, B. E., Lowe, L. P., Trimble, E. R., Coustan, D. R., Hadden, D. R., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1790 · Cited by 954 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Þorleifsson, G., Jackson, A., Allen, H. L., Lindgren, C. M., Luan, J., Mägi, R., et al. (2010) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/d3bn-7g86 · Cited by 767 · see citing works
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, J., Tukiainen, T., Sarin, A.-P., Ortega-Alonso, A., Tikkanen, E., Lyytikäinen, L.-P., Kangas, A. J., Soininen, P., Würtz, P., Silander, K., et al. (2012) · Nature Genetics · doi:10.1038/ng.1073 · Cited by 553 · see citing works
Self-citationNetherlands Twin Register: From Twins to Twin Families
Boomsma, D., de Geus, E. D., Vink, J., Stubbe, J., Distel, M., Hottenga, J., Posthuma, D., van Beijsterveldt, T. V., Hudziak, J., Bartels, M., et al. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.6.849 · Cited by 551 · see citing works
Self-citationThe Generation R Study: Design and cohort update 2012
Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., et al. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9735-1 · Cited by 546 · see citing works
Risk factors and outcomes of maternal obesity and excessive weight gain during pregnancy
Gaillard, R., Durmuş, B., Albert Hofman, D., Mackenbach, J. P., Steegers, E. A. P., & Jaddoe, V. W. V. (2013) · Obesity · doi:10.1002/oby.20088 · Cited by 492 · see citing works
Hyperglycemia and Adverse Pregnancy Outcomes: The HAPO Study Cooperative Research Group
The HAPO Study Cooperative Research Group (2008) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0b013e318187b7a2 · Cited by 488 · see citing works
Hyperglycemia and Adverse Pregnancy Outcomes
Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Chaovarindr, U., Coustan, D. R., Hadden, D. R., McCance, D. R., Hod, M., McIntyre, H. D., et al. (2009) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000344706.95925.dc · Cited by 479 · see citing works
Rich-Edwards, J. W., Fraser, A., Lawlor, D. A., & Catov, J. M. (2014) · Epidemiologic Reviews · doi:10.1093/epirev/mxt006 · Cited by 417 · see citing works
Netherlands Twin Register: From Twins to Twin Families
Boomsma, D. I., de Geus, E. J. C., Vink, J. M., Stubbe, J. H., Distel, M. A., Hottenga, J., Danielle Posthuma, B., van Beijsterveldt, T. C. E. M., Hudziak, J. J., Bartels, M., et al. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706779462426 · Cited by 401 · see citing works
HAPO Study Cooperative Research Group (2010) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02486.x · Cited by 395 · see citing works
Groups at risk in low birth weight infants and perinatal mortality.
Rantakallio, P. T. (1969) · PubMed · Cited by 384 · see citing works
Vimaleswaran, K. S., Cavadino, A., Berry, D. J., Jorde, R., Dieffenbach, A. K., Lu, C., Alves, A. C., Heerspink, H. J. L., Tikkanen, E., Eriksson, J., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70113-5 · Cited by 370 · see citing works
Leffelaar, E., Vrijkotte, T. G. M., & van Eijsden, M. (2010) · British Journal Of Nutrition · doi:10.1017/s000711451000022x · Cited by 360 · see citing works
Bodnar, L. M., Catov, J. M., Zmuda, J. M., Cooper, M. E., Parrott, M. S., Roberts, J. M., Marazita, M. L., & Simhan, H. N. (2010) · Journal of Nutrition · doi:10.3945/jn.109.119636 · Cited by 286 · see citing works
Würtz, P., Wang, Q., Kangas, A. J., Richmond, R. C., Skarp, J., Tiainen, M., Tynkkynen, T., Soininen, P., Havulinna, A. S., Kaakinen, M., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001765 · Cited by 280 · see citing works
Self-citationA Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
Kwak, S. H., Kim, S., Cho, Y. M., Go, M. J., Cho, Y. S., Choi, S. H., Moon, M. K., Jung, H. S., Shin, H. D., Kang, H. M., et al. (2012) · Diabetes · doi:10.2337/db11-1034 · Cited by 273 · see citing works
Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans
Medland, S. E., Nyholt, D. R., Painter, J. N., McEvoy, B. P., McRae, A. F., Zhu, G., Gordon, S. D., Ferreira, M. A. R., Wright, M. J., Henders, A. K., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.009 · Cited by 261 · see citing works
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Freathy, R. M., Mook‐Kanamori, D. O., Sovio, U., Prokopenko, I., Timpson, N. J., Berry, D. J., Warrington, N. M., Widén, E., Hottenga, J., Kaakinen, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.567 · Cited by 255 · see citing works
(2015) · Apple Academic Press eBooks · doi:10.1201/b18536-15 · Cited by 255 · see citing works
The UK Adult Twin Registry (TwinsUK Resource)
Moayyeri, A., Hammond, C. J., Hart, D. J., & Spector, T. D. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.89 · Cited by 251 · see citing works
Cohort Profile: TwinsUK and Healthy Ageing Twin Study
Moayyeri, A., Hammond, C. J., Valdes, A. M., & Spector, T. D. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr207 · Cited by 239 · see citing works
A. Lawlor, D., Fraser, A., Lindsay, R. S., Ness, A., Dabelea, D., Catalano, P., Davey Smith, G., Sattar, N., & Nelson, S. M. (2010) · Diabetologia · doi:10.1007/s00125-009-1560-z · Cited by 238 · see citing works
Bisgaard, H. F. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61398-1 · Cited by 232 · see citing works
The Pregnant Diabetic and Her Newborn. Problems and Management
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.229.391-a · Cited by 224 · see citing works
Ehret, G. (2010) · Current Hypertension Reports · doi:10.1007/s11906-009-0086-6 · Cited by 217 · see citing works
The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A.-P., Thorleifsson, G., Ladenvall, C., Kals, M., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001474 · Cited by 203 · see citing works
Self-citationShin, D., & Song, W. O. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.964675 · Cited by 200 · see citing works
Maternal adiposity—a determinant of perinatal and offspring outcomes?
Lawlor, D. A., Relton, C., Sattar, N., & Nelson, S. M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.176 · Cited by 192 · see citing works
Self-citationLowe, L. P., Metzger, B. E., Lowe, W. L., Dyer, A. R., McDade, T. W., & McIntyre, D. H. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1662 · Cited by 172 · see citing works
Continuous Glucose Profiles in Obese and Normal-Weight Pregnant Women on a Controlled Diet
Harmon, K. A., Gerard, L., Jensen, D. R., Kealey, E. H., Hernandez, T. L., Reece, M. S., Barbour, L. A., & Bessesen, D. H. (2011) · Diabetes Care · doi:10.2337/dc11-0723 · Cited by 172 · see citing works
The relationship between maternal glycemia and perinatal outcome
Landon, M. B., Mele, L., Spong, C. Y., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., et al. (2011) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e318203ebe0 · Cited by 150 · see citing works
Hayes, M. G., Urbanek, M., Hivert, M., Armstrong, L. L., Morrison, J., Guo, C., Lowe, L. P., Scheftner, D. A., Pluzhnikov, A., Levine, D., et al. (2013) · Diabetes · doi:10.2337/db12-1692 · Cited by 140 · see citing works
Lacroix, M., Battista, M., Doyon, M., Ménard, J., Ardilouze, J., Perron, P., & Hivert, M. (2013) · Diabetes Care · doi:10.2337/dc12-1731 · Cited by 122 · see citing works
Yaghootkar, H., Lamina, C., Scott, R. A., Dastani, Z., Hivert, M., Warren, L. L., Stančáková, A., Buxbaum, S. G., Lyytikäinen, L., Henneman, P., et al. (2013) · Diabetes · doi:10.2337/db13-0128 · Cited by 121 · see citing works
Maternal Lipids Are as Important as Glucose for Fetal Growth
Kulkarni, S. R., Kumaran, K., Rao, S. R., Chougule, S. D., Deokar, T. M., Bhalerao, A. J., Solat, V. A., Bhat, D., Fall, C. H. D., & Yajnik, C. S. (2013) · Diabetes Care · doi:10.2337/dc12-2445 · Cited by 114 · see citing works
The Danish National Birth Cohort its background, structure and aim
Olsen, M. M. J. (2001) · Scandinavian Journal of Public Health · doi:10.1080/140349401317115268 · Cited by 112 · see citing works
Severe Obesity in Young Women and Reproductive Health: The Danish National Birth Cohort
Nohr, E. A., Timpson, N. J., Andersen, C. S., Smith, G. D., Olsen, J., & Sørensen, T. I. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008444 · Cited by 111 · see citing works
Maternal Serum Lipids During Pregnancy and Infant Birth Weight: The Influence of Prepregnancy BMI
Misra, V. K., Trudeau, S., & Perni, U. C. (2011) · Obesity · doi:10.1038/oby.2011.43 · Cited by 110 · see citing works
Associations of Blood Pressure Change in Pregnancy With Fetal Growth and Gestational Age at Delivery
Macdonald-Wallis, C. M., Tilling, K. M., Fraser, A., Nelson, S. M., & Lawlor, D. A. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02766 · Cited by 110 · see citing works
Freathy, R. M., Hayes, M. G., Urbanek, M., Lowe, L. P., Lee, H., Ackerman, C. M., Frayling, T. M., Cox, N. J., Dunger, D. B., Dyer, A. R., et al. (2010) · Diabetes · doi:10.2337/db10-0177 · Cited by 105 · see citing works
Evaluation of Genetic Markers as Instruments for Mendelian Randomization Studies on Vitamin D
Berry, D. J., Vimaleswaran, K. S., Whittaker, J. C., Hingorani, A. D., & Hyppönen, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037465 · Cited by 88 · see citing works
Birth weight of offspring and insulin resistance in late adulthood: cross sectional survey
Lawlor, D. A., Smith, G. D., & Ebrahim, S. (2002) · BMJ · doi:10.1136/bmj.325.7360.359 · Cited by 77 · see citing works
Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene
Zhao, J., Li, M., Bradfield, J. P., Wang, K., Zhang, H., Abou‐Sleiman, P. M., Kim, C. E., Annaiah, K., Glaberson, W., Glessner, J., et al. (2009) · Diabetes · doi:10.2337/db09-0506 · Cited by 67 · see citing works
Silverwood, R. J., Holmes, M. V., Dale, C. E., Lawlor, D. A., Whittaker, J. C., Smith, G. D., Leon, D. A., Palmer, T., Keating, B. J., Zuccolo, L., et al. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu187 · Cited by 66 · see citing works
The Exeter Family Study of Childhood Health (EFSOCH): study protocol and methodology
Knight, B., Shields, B. M., & Hattersley, A. T. (2006) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2006.00701.x · Cited by 62 · see citing works
52: The relationship between maternal glycemia and perinatal outcome
Landon, M. B. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.10.067 · Cited by 24 · see citing works
The Relationship Between Maternal Glycemia and Perinatal Outcome
Landon, M. B., Mele, L., & Spong, C. Y. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31821769ff · Cited by 22 · see citing works
Schlemm, L., Haumann, H., Ziegner, M., Stirnberg, B., Sohn, A., Alter, M., Pfab, T., Kalache, K. D., Guthmann, F., & Hocher, B. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328336a090 · Cited by 18 · see citing works
Hayes, M. G., Urbanek, M., Hivert, M., Armstrong, L., Morrison, J., Guo, C., Lowe, L., Scheftner, D. A., Pluzhnikov, A., Dm, L., et al. (2013) · Diabetes · doi:10.2337/db13-er10 · Cited by 6 · see citing works
(2000) · Time to knit · doi:10.1016/j.yend.2013.03.057 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Skrivankova, V. W., Richmond, R. C., Woolf, B. A. R., Davies, N. M., Swanson, S. A., VanderWeele, T. J., Timpson, N. J., Higgins, J. P. T., Dimou, N., Langenberg, C., et al. (2021) · BMJ · doi:10.1136/bmj.n2233 · Cited by 1,648 · see citing works
Triangulation in aetiological epidemiology
Lawlor, D. A., Tilling, K., & Davey Smith, G. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyw314 · Cited by 1,129 · see citing works
Self-citationMendelian Randomization: Concepts and Scope
Richmond, R. C., & Davey Smith, G. (2022) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a040501 · Cited by 841 · see citing works
Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L., Bergström, A., Charles, M., Chatzi, L., Chevrier, C., Chrousos, G., et al. (2019) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15661 · Cited by 591 · see citing works
Warrington, N. M., Beaumont, R. N., Horikoshi, M., Day, F. R., Helgeland, Ø., Laurin, C., Bačelis, J., Peng, S., Hao, K., Feenstra, B., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0403-1 · Cited by 574 · see citing works
Voerman, E., Santos, S., Patro-Gołąb, B., Amiano, P., Ballester, F., Barros, H., Bergström, A., Charles, M.-A. A., Chatzi, L., Chevrier, C., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002744 · Cited by 526 · see citing works
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi, M., Beaumont, R. N., Day, F. R., Warrington, N. M., Kooijman, M. N., Fernandez-Tajes, J. J., Feenstra, B., van Zuydam, N. R., Gaulton, K. J., Grarup, N., et al. (2016) · Nature · doi:10.1038/nature19806 · Cited by 495 · see citing works
Using genetic data to strengthen causal inference in observational research
Pingault, J.-B., O’Reilly, P. F., Schoeler, T., Ploubidis, G. B., Rijsdijk, F., & Dudbridge, F. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0020-3 · Cited by 444 · see citing works
Nutrition in the First 1000 Days: The Origin of Childhood Obesity
Mameli, C., Mazzantini, S., & Zuccotti, G. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13090838 · Cited by 278 · see citing works
Belbasis, L., Savvidou, M. D., Kanu, C., Evangelou, E., & Tzoulaki, I. (2016) · BMC Medicine · doi:10.1186/s12916-016-0692-5 · Cited by 237 · see citing works
Küpers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., Page, C. M., Reese, S. E., Wilcox, A. J., Czamara, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09671-3 · Cited by 233 · see citing works
‘Mendelian randomization’: an approach for exploring causal relations in epidemiology
Gupta, V., Walia, G. K., & SACHDEVA, M. P. (2017) · Public Health · doi:10.1016/j.puhe.2016.12.033 · Cited by 214 · see citing works
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
Wang, Q., Würtz, P., Auro, K. M., Mäkinen, V., Kangas, A. J., Soininen, P., Tiainen, M., Tynkkynen, T., Jokelainen, J. J., Santalahti, K., et al. (2016) · BMC Medicine · doi:10.1186/s12916-016-0733-0 · Cited by 205 · see citing works
Associations of Maternal Diabetes and Body Mass Index With Offspring Birth Weight and Prematurity
Kong, L., Nilsson, I. A. K., Gissler, M., & Lavebratt, C. (2019) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2018.5541 · Cited by 197 · see citing works
Obesity and gynaecological and obstetric conditions: umbrella review of the literature
Kalliala, I. E. J., Markozannes, G., Gunter, M. J., Paraskevaidis, E. A., Gabra, H., Mitra, A., Terzidou, V., Bennett, P. R., Martin‐Hirsch, P. L., Tsilidis, K. K., et al. (2017) · BMJ · doi:10.1136/bmj.j4511 · Cited by 197 · see citing works
Beaumont, R. N., Warrington, N. M., Cavadino, A., Tyrrell, J., Nodzenski, M., Horikoshi, M., Geller, F., Myhre, R., Richmond, R. C., Paternoster, L., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddx429 · Cited by 174 · see citing works
Pathophysiology from preconception, during pregnancy, and beyond.
Hivert, M.-F., Backman, H., Benhalima, K., Catalano, P., Desoye, G., Immanuel, J., McKinlay, C. J. D., Meek, C. L., Nolan, C. J., Ram, U., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00827-4 · Cited by 186 · see citing works
Genetics and neurobiology of eating disorders
Bulik, C. M., Coleman, J. R. I., Hardaway, J. A., Breithaupt, L. E., Watson, H. J., Bryant, C. D., & Breen, G. D. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01071-z · Cited by 154 · see citing works
Patro-Gołąb, B., Santos, S., Voerman, E., Lawlor, D. A., Jaddoe, V. W. V., Gaillard, R., Patro-Gołąb, B., Santos, S., Voerman, E., Barros, H., et al. (2018) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(18)30273-6 · Cited by 147 · see citing works
McAuliffe, F. M., Killeen, S. L., Jacob, C. M., Hanson, M. A., Hadar, E., McIntyre, D. H., Kapur, A., Kihara, A., Ronald, C. W., Divakar, H., et al. (2020) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13334 · Cited by 163 · see citing works
Lawlor, D. A., Richmond, R. C., Warrington, N. M., McMahon, G., Smith, G. D., Bowden, J., & Evans, D. M. (2017) · Wellcome Open Research · doi:10.12688/wellcomeopenres.10567.1 · Cited by 129 · see citing works
Insulin suppresses the production of fibroblast growth factor 23 (FGF23)
Bär, L., Feger, M., Fajol, A., Klotz, L., Zeng, S., Lang, F. J. W., Hocher, B., & Föller, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800160115 · Cited by 124 · see citing works
Hypertensive Disorders of Pregnancy and DNA Methylation in Newborns
Kazmi, N., Sharp, G. C., Reese, S. E., Vehmeijer, F. O. L., Lahti, J. M. T., Page, C. M., Zhang, W., Rifas‐Shiman, S. L., Rezwan, F. I., Simpkin, A. J., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12634 · Cited by 124 · see citing works
Patel, N., Godfrey, K. M., Pasupathy, D., Levin, J., Flynn, A. C., Hayes, L., Briley, A. L., Bell, R., Lawlor, D. A., Oteng‐Ntim, E., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.44 · Cited by 115 · see citing works
Fan, Q., Maranville, J., Fritsche, L. G., Sim, X., Cheung, C. M. G., Chen, L. J., Gorski, M., Yamashiro, K., Ahn, J., Laude, A., et al. (2017) · International Journal of Epidemiology · doi:10.1093/ije/dyx189 · Cited by 109 · see citing works
Impact of vitamin D on pregnancy-related disorders and on offspring outcome
von Websky, K., Hasan, A. A., Reichetzeder, C., Tsuprykov, O., & Hocher, B. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.11.008 · Cited by 109 · see citing works
Fontanarosa, P., Bauchner, H., & Flanagin, A. (2017) · JAMA · doi:10.1001/jama.2017.19341 · Cited by 102 · see citing works
Huang, C., Li, J., Qin, G., Liew, Z., Hu, J., László, K. D., Tao, F., Obel, C., Olsen, J., & Yu, Y. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003805 · Cited by 96 · see citing works
Distinction between the effects of parental and fetal genomes on fetal growth
Juliusdottir, T., Steinthórsdóttir, V., Stefánsdóttir, L., Sveinbjörnsson, G., Ivarsdottir, E. V., Þórólfsdóttir, R. B., Sigurdsson, J. K., Tragante, V., Hjörleifsson, K. E., Helgadóttir, A., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00896-x · Cited by 94 · see citing works
Sandler, V., Reisetter, A. C., Bain, J. R., Muehlbauer, M. J., Nodzenski, M., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4182-2 · Cited by 94 · see citing works
Evans, D. M., Moen, G.-H., Hwang, L., Lawlor, D. A., & Warrington, N. M. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz019 · Cited by 91 · see citing works
Ferreira, D. L. S., Williams, D. M., Kangas, A. J., Soininen, P., Ala‐Korpela, M., Smith, G. D., Järvelin, M., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002376 · Cited by 91 · see citing works
Kaul, P., Bowker, S. L., Savu, A., Yeung, R. O., Donovan, L., & Ryan, E. A. (2018) · Diabetologia · doi:10.1007/s00125-018-4758-0 · Cited by 89 · see citing works
Valent, A. M., DeArmond, C., Houston, J. M., Reddy, S., Masters, H. R., Gold, A. D., Boldt, M., DeFranco, E., Evans, A. T., & Warshak, C. R. (2017) · JAMA · doi:10.1001/jama.2017.10567 · Cited by 88 · see citing works
Differential methylation of genes in individuals exposed to maternal diabetes in utero
Chen, P., Piaggi, P., Traurig, M. T., Bogardus, C., Knowler, W. C., Baier, L. J., & Hanson, R. L. (2017) · Diabetologia · doi:10.1007/s00125-016-4203-1 · Cited by 85 · see citing works
Yang, Q., Sanderson, E., Tilling, K., Borges, M. C., & Lawlor, D. A. (2019) · doi:10.1101/19009605 · Cited by 85 · see citing works
Chen, J., Bačelis, J., Solé-Navais, P., Srivastava, A. K., Juodakis, J., Rouse, A., Hallman, M., Teramo, K., Melbye, M., Feenstra, B., et al. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003305 · Cited by 76 · see citing works
Richmond, R. C., Timpson, N. J., Felix, J. F., Palmer, T., Gaillard, R., McMahon, G., Smith, G. D., Jaddoe, V. W. V., & Lawlor, D. A. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002221 · Cited by 80 · see citing works
Long-term consequences of obesity on female fertility and the health of the offspring
Chandrasekaran, S., & Neal-Perry, G. S. (2017) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000364 · Cited by 79 · see citing works
Lawlor, D. A., Lewcock, M., Jones, L. R., Rollings, C., Yip, V., Major‐Smith, D., Pearson, R. M., Johnson, L., Millard, L. A. C., Patel, N., et al. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15087.2 · Cited by 77 · see citing works
The impact of obesity: a narrative review
Lam, B. C. C., Lim, A. Y. L., Chan, S. L., Yum, M. P. S., Koh, N. S. Y., & Finkelstein, E. A. (2023) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2022-232 · Cited by 74 · see citing works
Paternal programming of offspring cardiometabolic diseases in later life
Li, J., Tsuprykov, O., Yang, X., & Hocher, B. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001051 · Cited by 73 · see citing works
Beaumont, R. N., Flatley, C. J., Vaudel, M., Wu, X., Chen, J., Moen, G.-H., Skotte, L., Helgeland, Ø., Solé-Navais, P., Banasik, K., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01520-w · Cited by 68 · see citing works
Estimation of Parental Effects Using Polygenic Scores
Balbona, J. V., Kim, Y., & Keller, M. C. (2021) · Behavior Genetics · doi:10.1007/s10519-020-10032-w · Cited by 71 · see citing works
Maternal obesity and prenatal programming
Elshenawy, S., & Simmons, R. A. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.002 · Cited by 72 · see citing works
Hannon, E. J., Schendel, D., Ladd‐Acosta, C., Grove, J., Hansen, C. S., HOUGAARD, D. M., Bresnahan, M. A., Mors, O. N., Hollegaard, M. V., Bækvad‐Hansen, M., et al. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0120 · Cited by 67 · see citing works
Hwang, L., Lawlor, D. A., Freathy, R. M., Evans, D. M., & Warrington, N. M. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz160 · Cited by 67 · see citing works
The Unrelenting Challenge of Obesity
Zylke, J. W., & Bauchner, H. (2016) · JAMA · doi:10.1001/jama.2016.6190 · Cited by 64 · see citing works
Kadakia, R., Nodzenski, M., Talbot, O., Kuang, A., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Ilkayeva, O., O’Neal, S., Lowe, L. P., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4781-1 · Cited by 61 · see citing works
Simpson, J., Smith, A. D. A. C., Fraser, A., Sattar, N. A., Lindsay, R. S., Ring, S. M., Tilling, K. M., Smith, G. D., Lawlor, D. A., & Nelson, S. M. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2342 · Cited by 61 · see citing works
Power, G. M., Sanderson, E. C. M., Pagoni, P., Fraser, A., Morris, T., Prince, C., Frayling, T. M., Heron, J., Richardson, T. G., Richmond, R. C., et al. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-01032-1 · Cited by 61 · see citing works
Perales, M., Artal, R., & Lucía, A. (2017) · JAMA · doi:10.1001/jama.2017.0593 · Cited by 59 · see citing works
Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesisPreprint
Anderson, W. D., Soh, J. Y., Innis, S. E., Dimanche, A., Ma, L., Langefeld, C. D., Comeau, M. E., Das, S. K., Schadt, E. E., Björkegren, J., et al. (2020) · Genome Research · doi:10.1101/gr.264614.120 · Cited by 58 · see citing works
In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?
Graham, C., Chooniedass, R., Stefura, W. P., Becker, A. B., Sears, M. R., Turvey, S. E., Mandhane, P. J., Subbarao, P., CHILD Study Investigators, & HayGlass, K. T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177813 · Cited by 56 · see citing works
Maternal and fetal genetic contribution to gestational weight gain
Warrington, N. M., Richmond, R. C., Feenstra, B., Myhre, R., Gaillard, R., Paternoster, L., Wang, C. A., Beaumont, R. N., Das, S., Murcia, M., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.248 · Cited by 52 · see citing works
Genetic studies of gestational duration and preterm birth
Zhang, G., Srivastava, A. K., Bačelis, J., Juodakis, J., Jacobsson, B., & Muglia, L. J. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.05.003 · Cited by 54 · see citing works
Metabolic signatures of birthweight in 18 288 adolescents and adults
Würtz, P., Wang, Q., Niironen, M., Tynkkynen, T., Tiainen, M., Drenos, F., Kangas, A. J., Soininen, P., Skilton, M. R., Heikkila, K. V., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw255 · Cited by 49 · see citing works
The Born in Guangzhou Cohort Study enables generational genetic discoveries
Huang, S., Liu, S. M., Huang, M., He, J., Wang, C., Wang, T., Feng, X., Kuang, Y., Lu, J., Gu, Y., et al. (2024) · Nature · doi:10.1038/s41586-023-06988-4 · Cited by 45 · see citing works
Phenotype as Agent for Epigenetic Inheritance
Torday, J. S., & Miller, W. L. (2016) · Biology · doi:10.3390/biology5030030 · Cited by 47 · see citing works
Baugh, N., Harris, D. E., Aboueissa, A., Sarton, C., & Lichter, E. L. (2016) · Journal of Pregnancy · doi:10.1155/2016/5871313 · Cited by 47 · see citing works
Middeldorp, C. M., Felix, J. F., Mahajan, A., & McCarthy, M. I. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00502-9 · Cited by 43 · see citing works
Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight
Hughes, A. E., Nodzenski, M., Beaumont, R. N., Talbot, O., Shields, B. M., Scholtens, D. M., Knight, B., Lowe, W. L., Hattersley, A. T., & Freathy, R. M. (2018) · Diabetes · doi:10.2337/db17-1188 · Cited by 46 · see citing works
Thompson, W., Tyrrell, J., Borges, M. C., Beaumont, R. N., Knight, B., Wood, A. R., Ring, S. M., Hattersley, A. T., Freathy, R. M., & Lawlor, D. A. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002828 · Cited by 45 · see citing works
Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study
Gupta, V., Saxena, R., Walia, G. K., Agarwal, T., Vats, H., Dunn, W. B., Relton, C. L., Sovio, U., Papageorghiou, A. T., Smith, G. D., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025395 · Cited by 44 · see citing works
Mir, S. A., Chen, L., Burugupalli, S., Burla, B., Ji, S., Smith, A., Narasimhan, K., Ramasamy, A., Tan, K. M. L., Huynh, K., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02432-y · Cited by 43 · see citing works
Bond, T. A., Richmond, R. C., Karhunen, V., Cuéllar-Partida, G., Borges, M. C., Zuber, V., Alves, A. C., Mason, D., Yang, T., Gunter, M. J., et al. (2022) · BMC Medicine · doi:10.1186/s12916-021-02216-w · Cited by 43 · see citing works
Causal inference in obesity research
Franks, P. W., & Atabaki‐Pasdar, N. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12577 · Cited by 42 · see citing works
The metabolic landscape of decidua in recurrent pregnancy loss using a global metabolomics approach
Wang, L., Liu, H., Zhao, S.-J., Shen, L. W., Xie, T., Luo, J., Mor, G., & Liao, A. (2021) · Placenta · doi:10.1016/j.placenta.2021.07.001 · Cited by 40 · see citing works
Borges, M. C., Clayton, G., Freathy, R. M., Felix, J. F., Fernández‐Sanlés, A., Soares, A. G., Kilpi, F., Yang, Q., McEachan, R., Richmond, R. C., et al. (2024) · BMC Medicine · doi:10.1186/s12916-023-03167-0 · Cited by 40 · see citing works
Integrating Family-Based and Mendelian Randomization DesignsPreprint
Hwang, L., Davies, N. M., Warrington, N. M., & Evans, D. M. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039503 · Cited by 40 · see citing works
Costa-Júnior, J. M., Ferreira, S. M., Kurauti, M. A., Bernstein, D., Ruano, E. G., Kameswaran, V., Schug, J., Freitas-Dias, R., Zoppi, C., Boschero, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010001 · Cited by 39 · see citing works
Zheng, J., Liu, H., Ong, K. K., Huang, T., Guan, Y., Huang, Y., Yang, B., Wang, F., & Li, D. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01500 · Cited by 39 · see citing works
Developmental Programming of Body Composition: Update on Evidence and Mechanisms
ISGANAITIS, E. M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1170-1 · Cited by 36 · see citing works
Gray, K. J., Kovacheva, V., Mirzakhani, H., Bjonnes, A., Almoguera, B., Wilson, M. L., Ingles, S. A., Lockwood, C. J., Hakonarson, H. H., McElrath, T. F., et al. (2020) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16441 · Cited by 36 · see citing works
Qian, Y., Zhang, Y., Fan, X., Yan, H., Li, X., Fan, Y., Song, Y., Ma, S., Hu, Z., Gao, X., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac567 · Cited by 35 · see citing works
Tripathi, R. R., Rifas‐Shiman, S. L., Hawley, N. L., Hivert, M., & Oken, E. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007426 · Cited by 35 · see citing works
Gaillard, R., & Jaddoe, V. W. V. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00869-z · Cited by 34 · see citing works
Lawn, R. B., Lawlor, D. A., & Fraser, A. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx308 · Cited by 34 · see citing works
Cioffi, C. E., Figueroa, J., & Welsh, J. A. (2018) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.10.021 · Cited by 34 · see citing works
Aji, A. S., Erwinda, E., Rasyid, R., Yusrawati, Y., Malik, S. G., Alathari, B. E., Lovegrove, J. A., Lipoeto, N. I., & Vimaleswaran, K. S. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00480-5 · Cited by 34 · see citing works
Mechanick, J. I., Adams, S., Davidson, J. A., Fergus, I. V., Galindo, R. J., McKinney, K. H., Petak, S. M., Sadhu, A., Samson, S. L., Vedanthan, R., et al. (2019) · Endocrine Practice · doi:10.4158/ps-2019-0080 · Cited by 34 · see citing works
Prenatal determinants of childhood obesity: a review of risk factors
Liao, X., Yu, Y., Marc, I., Dubois, L., Abdelouahab, N., Bouchard, L., Wu, Y., Ouyang, F., Huang, H.-F., & Fraser, W. D. (2019) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0403 · Cited by 34 · see citing works
Tian, M., Reichetzeder, C., Li, J., & Hocher, B. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002156 · Cited by 32 · see citing works
Warrington, N. M., Hwang, L., Nivard, M. G., & Evans, D. M. (2021) · Nature Communications · doi:10.1038/s41467-021-25723-z · Cited by 37 · see citing works
Hwang, L., Tubbs, J. D., Luong, J., Lundberg, M., Moen, G.-H., Wang, G., Warrington, N. M., Sham, P. C., Cuéllar-Partida, G., & Evans, D. M. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009154 · Cited by 28 · see citing works
D’Urso, S., Wang, G., Hwang, L., Moen, G.-H., Warrington, N. M., & Evans, D. M. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420001105 · Cited by 30 · see citing works
Yang, Q., Magnus, M. C., Kilpi, F., Santorelli, G., Soares, A. G., West, J., Magnus, P. M., Wright, J., Håberg, S. E., Sanderson, E. C. M., et al. (2022) · BMC Medicine · doi:10.1186/s12916-022-02494-y · Cited by 29 · see citing works
Zhao, J., Stewart, I. D., Baird, D. A., Mason, D., Wright, J., Zheng, J., Gaunt, T. R., Evans, D. M., Freathy, R. M., Langenberg, C., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104441 · Cited by 30 · see citing works
Precision Medicine in Obesity and Type 2 Diabetes: The Relevance of Early-Life Exposures
Estampador, A. C., & Franks, P. W. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.273540 · Cited by 29 · see citing works
Vitamin D: effects on pregnancy, maternal, fetal and postnatal outcomes
Константиновна, Е. А., Mokrysheva, N., Pigarova, E. A., & Mirnaya, S. S. (2018) · Terapevticheskii arkhiv · doi:10.26442/terarkh20189010115-127 · Cited by 29 · see citing works
de Almeida-Faria, J., Duque-Guimaraes, D. E., Ong, T. P., Pantaleão, L. C., Carpenter, A. A. M., Loche, E., Kusinski, L. C., Ashmore, T. J., Antrobus, R., Bushell, M., et al. (2021) · Diabetologia · doi:10.1007/s00125-020-05357-4 · Cited by 28 · see citing works
Childhood obesity from the genes to the epigenome
Sivakumar, S., Lama, D., & Rabhi, N. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1393250 · Cited by 27 · see citing works
Bond, T. A., Karhunen, V., Wielscher, M., AUVINEN, J. P., Männikkö, M., Keinanen-Kiukaanniemi, S. M., Gunter, M. J., Felix, J. F., Prokopenko, I., Yang, J., et al. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz095 · Cited by 25 · see citing works
Beaumont, R. N., Kotecha, S. J., Wood, A. R., Knight, B., Sebert, S. P., McCarthy, M. I., Hattersley, A. T., Järvelin, M., Timpson, N. J., Freathy, R. M., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009191 · Cited by 26 · see citing works
Zeng, J., Shen, F., Zou, Z.-Y., Yang, R.-X., Jin, Q.-F., Yang, J., Chen, G.-Y., & Fan, J.-G. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i16.1681 · Cited by 25 · see citing works
Andraweera, P. H., Dekker, G., Leemaqz, S., McCowan, L. M. E., & Roberts, C. T. (2016) · Obesity · doi:10.1002/oby.21662 · Cited by 24 · see citing works
Putra, S. E. D., Reichetzeder, C., Meixner, M., Liere, K., Slowinski, T., & Hocher, B. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001450 · Cited by 24 · see citing works
Taylor, K., Wootton, R. E., Yang, Q., Oddie, S., Wright, J., Yang, T., Magnus, M. C., Andreassen, O. A., Borges, M. C., Caputo, M., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02731-y · Cited by 24 · see citing works
Liu, J., Yeung, S. L. A., He, B., Kwok, M. K., Leung, G. M., & Schooling, C. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222141 · Cited by 23 · see citing works
Placental genetic variations in vitamin D metabolism and birthweight
Workalemahu, T., Badon, S. E., Dishi, M., Qiu, C., Williams, M. A., Sorensen, T. K., & Enquobahrie, D. A. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.028 · Cited by 23 · see citing works
- Authors
- Tyrrell, J., Richmond, R. C., Palmer, T. M., Feenstra, B., Rangarajan, J., Metrustry, S., Cavadino, A., Paternoster, L., Armstrong, L. L., De Silva, N. M. G., Wood, A. R., Horikoshi, M., Geller, F., Myhre, R., Bradfield, J. P., Kreiner-Møller, E., Huikari, V., Painter, J. N., Hottenga, J.-J., Allard, C., Berry, D. J., Bouchard, L., Das, S., Evans, D. M., Hakonarson, H., Hayes, M. G., Heikkinen, J., Hofman, A., Knight, B., Lind, P. A., McCarthy, M. I., McMahon, G., Medland, S. E., Melbye, M., Morris, A. P., Nodzenski, M., Reichetzeder, C., Ring, S. M., Sebert, S., Sengpiel, V., Sørensen, T. I. A., Willemsen, G., de Geus, E. J. C., Martin, N. G., Spector, T. D., Power, C., Järvelin, M.-R., Bisgaard, H., Grant, S. F. A., Nohr, E. A., Jaddoe, V. W., Jacobsson, B., Murray, J. C., Hocher, B., Hattersley, A. T., Scholtens, D. M., Davey Smith, G., Hivert, M.-F., Felix, J. F., Hyppönen, E., Lowe, W. L., Frayling, T. M., Lawlor, D. A., Freathy, R. M., & for the Early Growth Genetics (EGG) Consortium
- Affiliations
- University of Exeter (GB)
- Erasmus MC (NL)
- University of Warwick (GB)
- Statens Serum Institut (DK)
- Northwestern University (US)
- St Thomas' Hospital (GB)
- Queen Mary University of London (GB)
- University of Bristol (GB)
- Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom
- Centre for Human Genetics (GB)
- Norwegian Institute of Public Health (NO)
- Children's Hospital of Philadelphia (US)
- Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, and Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark
- University of Oulu (FI)
- QIMR Berghofer Medical Research Institute (AU)
- Amsterdam Public Health (NL)
- Université de Sherbrooke (CA)
- University College London (GB)
- Imperial College London (GB)
- Translational Research Institute (AU)
- University of Helsinki (FI)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands54Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
- University of Potsdam (DE)
- Sahlgrenska University Hospital (SE)
- University of Copenhagen (DK)
- EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands22Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands
- Oulu University Hospital (FI)
- University of Southern Denmark (DK)
- University of Iowa (US)
- School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom
- University of South Australia (AU)
- Corresponding author
- Lawlor, Debbie A.
- Freathy, Rachel M.
- ORCID
- Tyrrell, Jessica
- Richmond, Rebecca C.
- Palmer, Tom M.
- Feenstra, Bjarke
- Metrustry, Sarah
- Cavadino, Alana
- Paternoster, Lavinia
- Wood, Andrew R.
- Horikoshi, Momoko
- Geller, Frank
- Myhre, Ronny
- Painter, Jodie N.
- Hottenga, Jouke-Jan
- Allard, Catherine
- Bouchard, Luigi
- Evans, David M.
- Hakonarson, Hakon
- Hayes, M. Geoffrey
- Heikkinen, Jani
- Knight, Bridget
- Lind, Penelope A.
- McCarthy, Mark I.
- Medland, Sarah E.
- Melbye, Mads
- Morris, Andrew P.
- Nodzenski, Michael
- Reichetzeder, Christoph
- Ring, Susan M.
- Sebert, Sylvain
- Sengpiel, Verena
- Sørensen, Thorkild I. A.
- Willemsen, Gonneke
- Martin, Nicholas G.
- Spector, Tim D.
- Power, Christine
- Järvelin, Marjo-Riitta
- Bisgaard, Hans
- Grant, Struan F. A.
- Nohr, Ellen A.
- Jaddoe, Vincent W.
- Jacobsson, Bo
- Murray, Jeffrey C.
- Hocher, Berthold
- Hattersley, Andrew T.
- Scholtens, Denise M.
- Hivert, Marie-France
- Felix, Janine F.
- Hyppönen, Elina
- Lowe, William L.
- Frayling, Timothy M.
- Lawlor, Debbie A.
- Freathy, Rachel M.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-03-15
- Volume
- 315
- Issue
- 11
- Pages
- 1129
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4811305
- OpenAlex
- W2296845877
- Cited by
- 284
- References
- 69
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 18 · 2023: 32 · 2022: 33 · 2021: 27 · 2020: 27 · 2019: 31 · 2018: 24 · 2017: 28 · 2016: 23
- FWCI
- 40.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Research Exeter (University of Exeter) (acceptedVersion)
- Lancaster EPrints (Lancaster University) (submittedVersion)
- UniSA Research Outputs Repository (University of South Australia) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Figshare (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Juvenile Diabetes Research Foundation International (U01 DK062418)
- March of Dimes Foundation
- Massachusetts General Hospital
- Children's Hospital of Philadelphia
- University of Pennsylvania
- Canadian Diabetes Association
- Sundhed og Sygdom, Det Frie Forskningsråd
- South Australian Health and Medical Research Institute
- Université de Sherbrooke
- Wellcome Trust (098395, WT098017, 104150/Z/14/Z, WT083431MF, 102215, WT094529MA, 104150, WT088806)
- QIMR Berghofer Medical Research Institute
- National Institute for Health and Care Research (NF-SI-0611-10196, NF-SI-0611-10099, NF-SI-0611-10219, SI-0611-10196, NF-SI-0514-10027)
- Diabetes Research and Wellness Foundation
- British Heart Foundation
- Imperial College London
- University College London
- University of Oxford
- European Commission (633595)
- European Science Foundation
- University of Bristol
- National Research Foundation
- Deutsche Forschungsgemeinschaft
- Danmarks Grundforskningsfond
- University of South Australia
- ZonMw (VIDI 016. 136. 361, ZonMw-VIDI 016.136.361, 016.136.361)
- Erasmus Universiteit Rotterdam
- Vrije Universiteit Amsterdam
- Gentofte Hospital
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Lundbeckfonden
- Jinan University
- Novo Nordisk
- Universität Potsdam
- Augustinus Fonden
- Norges Forskningsråd
- Oulun Yliopisto
- Syddansk Universitet
- Svenska Läkaresällskapet
- Faculty of Health and Medical Sciences, University of Western Australia
- Egmont Fonden
- Novo Nordisk Foundation Center for Basic Metabolic Research
- H. Lundbeck A/S
- Terveyden ja hyvinvoinnin laitos
- Centre for Medical Systems Biology
- Norwegian Biodiversity Information Centre
- National Institutes of Health
- School of Medicine, Stanford University
- Perelman School of Medicine, University of Pennsylvania
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Medical Research Council (MR/N01104X/1, MC_PC_15015, MC_UU_12011/5, FT130101709, MC_PC_15018, MR/J012165/1)
- Sahlgrenska Akademin
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet
- European Regional Development Fund
- Strategic Research Council
- Klinisk Institut, Syddansk Universitet
- Biocenter, University of Oulu
- Diamantina Institute, University of Queensland
- Norwegian Institute of Public Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK10324, DK062418, U01DK062418, R01DK103246)
- National Institute of Neurological Disorders and Stroke
- National Institute of Environmental Health Sciences (P30ES013508)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD056465)
- Institute of Genetics
- Institute of Nutrition, Metabolism and Diabetes
- FP7 Ideas: European Research Council (323195)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- maternal obesity, body mass index, birth weight, causal inference, Mendelian randomization, maternal fasting glucose, type 2 diabetes, adiponectin, vitamin D status, HDL cholesterol, triglycerides, offspring growth, European ancestry women
- MeSH terms
- Adult, Birth Weight, Blood Glucose, Blood Pressure, Diabetes Mellitus, Type 2, Fasting, Female, Genotype, Humans, Infant, Newborn, Obesity, Pregnancy, Triglycerides, Body Mass Index, Polymorphism, Single Nucleotide, White People, Mendelian Randomization Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
