Rothman, Douglas L.

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 2,107

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,539

Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,311

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia

Diabetes, Cardiovascular Risks, and LipoproteinsAdvanced MRI Techniques and Applications

Cited by 1,264

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by13C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 1,248

Energy on demand.

Magistretti, P. J., Pellerin, L., Rothman, D. L., & Shulman, R. G. (1999) · Science

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 1,170

Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.

Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 897

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences

Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Cited by 759

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 757

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

Perseghin, G., Price, T. B., Petersen, K. F., Roden, M., Cline, G. W., Gerow, K., Rothman, D. L., & Shulman, G. I. (1996) · New England Journal of Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 699

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 675

Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy

Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry

Treatment of Major DepressionAdvanced MRI Techniques and Applications

Cited by 627

Energetic basis of brain activity: implications for neuroimaging

Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences

Advanced MRI Techniques and ApplicationsNeuroscience and Neuropharmacology Research

Cited by 590

Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With 13 C NMR

Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science

Metabolism, Diabetes, and CancerDiet, Metabolism, and Disease

Cited by 546

Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR

Shen, J., Petersen, K. F., Behar, K. L., Brown, P., Nixon, T. W., Mason, G. F., Petroff, O. A. C., Shulman, G. I., Shulman, R. G., & Rothman, D. L. (1999) · Proceedings of the National Academy of Sciences

Advanced MRI Techniques and ApplicationsAmino Acid Enzymes and Metabolism

Cited by 462

Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 453

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.

Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 408

Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by13C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism

Lebon, V., Petersen, K. F., Cline, G. W., Shen, J., Mason, G. F., Dufour, S., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2002) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 371

The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo

Patel, A. B., de Graaf, R. A., Mason, G. F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2005) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 343

In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function

Rothman, D. L., Behar, K. L., Hyder, F., & Shulman, R. G. (2003) · Annual Review of Physiology

Advanced MRI Techniques and ApplicationsNeuroscience and Neuropharmacology Research

Cited by 337

Decreased Muscle Glucose-Transport Phosphorylation Is an Early Defect in the Pathogenesis of Non-Insulin-Dependent Diabetes-Mellitus

Rothman, D. L., Magnusson, I., Cline, G., Gerard, D., Kahn, C. R., Shulman, R. G., & Shulman, G. I. (1995) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 325

13 C MRS studies of neuroenergetics and neurotransmitter cycling in humans

Rothman, D. L., De Feyter, H. M., de Graaf, R. A., Mason, G. F., & Behar, K. L. (2011) · NMR in Biomedicine

Advanced MRI Techniques and ApplicationsAdvanced NMR Techniques and Applications

Cited by 290

Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels

Hyder, F., Rothman, D. L., & Bennett, M. R. (2013) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 271

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

Taylor, R., Magnusson, I., Rothman, D. L., Cline, G. W., Caumo, A., Cobelli, C., & Shulman, G. I. (1996) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiet, Metabolism, and Disease

Cited by 258