Xie, Sharon X.
From the Frontotemporal Degeneration Center, Department of Neurology, (N.N., K.A.Q.C., S.A., C.A.O., S.S., G.A., C.G.-R., C.T.M., D.J.I., L.M., L.D., M.G.), Linguistic Data Consortium, Department of Linguistics (S.C., M.Y.L.), Penn Image Computing and Science Laboratory, Department of Radiology (C.A.O.), Department of Biostatistics, Epidemiology and Informatics (S.X.X.), and Department of Pathology and Laboratory Medicine (V.M.V.D.), Perelman School of Medicine, University of Pennsylvania,...
35 papers on CoChatORCID 0000-0002-7886-4103
Most cited papers
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Cognitive Therapy for the Prevention of Suicide Attempts: A Randomized Controlled Trial
Brown, G. K., Ten Have, T., Henriques, G. R., Xie, S. X., Hollander, J. E., & Beck, A. T. (2005) · JAMA
Suicide and Self-Harm StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Cited by 1,045
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Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre
Toledo, J. B., Arnold, S. E., Raible, K., Brettschneider, J., Xie, S. X., Grossman, M., Monsell, S. E., Kukull, W. A., & Trojanowski, J. Q. (2013) · Brain
Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments
Cited by 849
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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
Robinson, J. L., Lee, E. B., Xie, S. X., Rennert, L., Suh, E., Bredenberg, C., Caswell, C., Van Deerlin, V. M., Yan, N., Yousef, A., et al. (2018) · Brain
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 729
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Neuropathologic substrates of Parkinson disease dementia
Irwin, D. J., White, M. T., Toledo, J. B., Xie, S. X., Robinson, J. L., Van Deerlin, V., Lee, V. M. ‐., Leverenz, J. B., Montine, T. J., Duda, J. E., et al. (2012) · Annals of Neurology
Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research
Cited by 518
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Distribution patterns of tau pathology in progressive supranuclear palsy
Kovacs, G. G., Lukic, M. J., Irwin, D. J., Arzberger, T., Respondek, G., Lee, E. B., Coughlin, D., Giese, A., Grossman, M., Kurz, C., et al. (2020) · Acta Neuropathologica
Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments
Cited by 483
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Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
Nakashima-Yasuda, H., Uryu, K., Robinson, J., Xie, S. X., Hurtig, H., Duda, J. E., Arnold, S. E., Siderowf, A., Grossman, M., Leverenz, J. B., et al. (2007) · Acta Neuropathologica
Amyotrophic Lateral Sclerosis ResearchParkinson's Disease Mechanisms and Treatments
Cited by 468
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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E. B., Xie, S. X., Joyce, S., Li, C., et al. (2005) · Proceedings of the National Academy of Sciences
Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics
Cited by 413
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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
Zhang, B., Carroll, J., Trojanowski, J. Q., Yao, Y., Iba, M., Potuzak, J. S., Hogan, A.-M. L., Xie, S. X., Ballatore, C., Smith, A. B., et al. (2012) · The Journal of Neuroscience
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 401
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Cerebrospinal Fluid Tau and β-Amyloid: How Well Do These Biomarkers Reflect Autopsy-Confirmed Dementia Diagnoses?
Clark, C. M., Xie, S., Chittams, J., Ewbank, D., Peskind, E., Galasko, D., Morris, J. C., McKeel, D. W., Farlow, M., Weitlauf, S. L., et al. (2003) · Archives of Neurology
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments
Cited by 357
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Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy
Brunden, K. R., Zhang, B., Carroll, J., Yao, Y., Potuzak, J. S., Hogan, A.-M. L., Iba, M., James, M. J., Xie, S. X., Ballatore, C., et al. (2010) · The Journal of Neuroscience
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 320
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Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., Xie, S. X., Lee, V. M.-Y., & Trojanowski, J. Q. (2012) · Brain
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 281
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Clinical and Pathological Continuum of Multisystem TDP-43 Proteinopathies
Geser, F., Martinez-Lage, M., Robinson, J., Uryu, K., Neumann, M., Brandmeir, N. J., Xie, S. X., Kwong, L. K., Elman, L., McCluskey, L., et al. (2009) · Archives of Neurology
Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments
Cited by 267
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Longitudinal study of normal cognition in Parkinson disease
Pigott, K., Rick, J., Xie, S. X., Hurtig, H., Chen-Plotkin, A., Duda, J. E., Morley, J. F., Chahine, L. M., Dahodwala, N., Akhtar, R. S., et al. (2015) · Neurology
Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and Treatments
Cited by 251
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A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank
Toledo, J. B., Van Deerlin, V. M., Lee, E. B., Suh, E., Baek, Y., Robinson, J. L., Xie, S. X., McBride, J., Wood, E. M., Schuck, T., et al. (2014) · Alzheimer's & Dementia
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 234
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Symptom Burden Among Cancer Survivors: Impact of Age and Comorbidity
Mao, J. J., Armstrong, K., Bowman, M. A., Xie, S. X., Kadakia, R., & Farrar, J. T. (2007) · The Journal of the American Board of Family Medicine
Cancer survivorship and careChildhood Cancer Survivors' Quality of Life
Cited by 224
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The development and convergence of co-pathologies in Alzheimer’s disease
Robinson, J. L., Richardson, H., Xie, S. X., Suh, E., Van Deerlin, V. M., Alfaro, B., Loh, N., Porras-Paniagua, M., Nirschl, J. J., Wolk, D., et al. (2021) · Brain
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 203
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The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
Stutzbach, L. D., Xie, S. X., Naj, A. C., Albin, R., Gilman, S., PSP Genetics Study Group, Lee, V. M. Y., Trojanowski, J. Q., Devlin, B., & Schellenberg, G. D. (2013) · Acta Neuropathologica Communications
Endoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatments
Cited by 197
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CSF biomarkers cutoffs: The importance of coincident neuropathological diseases
Toledo, J. B., Brettschneider, J., Grossman, M., Arnold, S. E., Hu, W. T., Xie, S. X., Lee, V. M.-Y., Shaw, L. M., & Trojanowski, J. Q. (2012) · Acta Neuropathologica
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments
Cited by 182
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Risk factors for death of patients with cystic fibrosis awaiting lung transplantation
Belkin, R. A., Henig, N. R., Singer, L. G., Chaparro, C., Rubenstein, R. C., Xie, S. X., Yee, J. Y., Kotloff, R. M., Lipson, D. A., & Bunin, G. R. (2006) · American Journal of Respiratory and Critical Care Medicine
Transplantation: Methods and OutcomesCystic Fibrosis Research Advances
Cited by 180
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Longitudinal change in CSF Tau and Aβ biomarkers for up to 48 months in ADNI
Toledo, J. B., Xie, S. X., Trojanowski, J. Q., & Shaw, L. M. (2013) · Acta Neuropathologica
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments
Cited by 180
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Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial
Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016) · Phytomedicine
Medicinal Plant Extracts EffectsComplementary and Alternative Medicine Studies
Cited by 161
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Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis
Brettschneider, J., Libon, D. J., Toledo, J. B., Xie, S. X., McCluskey, L., Elman, L., Geser, F., Lee, V. M.-Y., Grossman, M., & Trojanowski, J. Q. (2012) · Acta Neuropathologica
Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms
Cited by 142
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Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
Kovacs, G. G., Robinson, J. L., Xie, S. X., Lee, E. B., Grossman, M., Wolk, D. A., Irwin, D. J., Weintraub, D., Kim, C. F., Schuck, T., et al. (2017) · Journal of Neuropathology & Experimental Neurology
Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research
Cited by 132
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The heterogeneity of mild cognitive impairment: A neuropsychological analysis
LIBON, D. J., XIE, S. X., EPPIG, J., WICAS, G., LAMAR, M., LIPPA, C., BETTCHER, B. M., PRICE, C. C., GIOVANNETTI, T., SWENSON, R., et al. (2010) · Journal of the International Neuropsychological Society
Dementia and Cognitive Impairment ResearchCognitive Functions and Memory
Cited by 130
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