Signer, Robert A.J.

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A., & Morrison, S. J. (2014) · Nature

Hematopoietic Stem Cell TransplantationRNA and protein synthesis mechanisms

Cited by 674

Mechanisms that Regulate Stem Cell Aging and Life Span

Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 320

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

Sun, X., Chuang, J.-C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L. H., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyChromatin Remodeling and Cancer

Cited by 161

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., DeMartino, G. N., Young, R. A., Sonenberg, N., & Morrison, S. J. (2016) · Genes & Development

Hematopoietic Stem Cell TransplantationRNA and protein synthesis mechanisms

Cited by 115

Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16 Ink4a and Arf

Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., & Dorshkind, K. (2008) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 102

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

Kruta, M., Sunshine, M. J., Chua, B. A., Fu, Y., Chawla, A., Dillingham, C. H., Hidalgo San Jose, L., De Jong, B., Zhou, F. J., & Signer, R. A. J. (2021) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationHeat shock proteins research

Cited by 100

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia

Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., McLaughlin, J., & Dorshkind, K. (2007) · Blood

Chronic Myeloid Leukemia TreatmentsAcute Myeloid Leukemia Research

Cited by 77

Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a

Berent-Maoz, B., Montecino-Rodriguez, E., Signer, R. A. J., & Dorshkind, K. (2012) · Blood

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 46

Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines

Porter, S. N., Cluster, A. S., Signer, R. A. J., Voigtmann, J., Monlish, D. A., Schuettpelz, L. G., & Magee, J. A. (2016) · Stem Cell Reports

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 22