Mechanisms that Regulate Stem Cell Aging and Life Span
Open accessAbstract
Mammalian aging is associated with reduced tissue regeneration, increased degenerative disease, and cancer. Because stem cells regenerate many adult tissues and contribute to the development of cancer by accumulating mutations, age-related changes in stem cells likely contribute to age-related morbidity. Consistent with this, stem cell function declines with age in numerous tissues as a result of gate-keeping tumor suppressor expression, DNA damage, changes in cellular physiology, and environmental changes in tissues. It remains unknown whether declines in stem cell function during aging influence organismal longevity. However, mechanisms that influence longevity also modulate age-related morbidity, partly through effects on stem cells.
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Stem cell DNA damage is often accompanied by oxidative stress, which is an accountable factor for stem cell senescence and aging.
“It has been suggested that stem cell DNA damage is often accompanied by oxidative stress, which is an accountable factor for stem cell senescence and aging [105, 106].”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [105]
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Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells
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Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells
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Ageing as developmental decay: insights from p16INK4a.
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The crossroads between cancer stem cells and aging
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Cellular Mechanisms of Somatic Stem Cell Aging
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- Authors
- Signer, R. A. J., & Morrison, S. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Morrison, Sean J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 12
- Issue
- 2
- Pages
- 152-165
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3641677
- OpenAlex
- W1990573718
- Cited by
- 320
- References
- 202
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 12 · 2022: 13 · 2021: 21 · 2020: 28 · 2019: 23 · 2018: 29 · 2017: 36 · 2016: 33 · 2015: 38 · 2014: 43 · 2013: 12
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Canadian Institutes of Health Research (106993_1)
- National Institute on Aging (R37AG024945, R01AG024945)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- stem cell aging, tissue regeneration, DNA damage, age-related degenerative diseases, cancer, age-related morbidity
- MeSH terms
- Animals, Humans, Stem Cells, Cellular Senescence
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