Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging
Open accessAbstract
Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis is necessary to preserve stem cell function, but little is known about the mechanisms that regulate proteostasis during stress in stem cells, and whether disruptions of proteostasis contribute to stem cell aging is largely unexplored. We determined that ex-vivo-cultured mouse and human hematopoietic stem cells (HSCs) rapidly increase protein synthesis. This challenge to HSC proteostasis was associated with nuclear accumulation of Hsf1, and deletion of Hsf1 impaired HSC maintenance ex vivo. Strikingly, supplementing cultures with small molecules that enhance Hsf1 activation partially suppressed protein synthesis, rebalanced proteostasis, and supported retention of HSC serial reconstituting activity. Although Hsf1 was dispensable for young adult HSCs in vivo, Hsf1 deficiency increased protein synthesis and impaired the reconstituting activity of middle-aged HSCs. Hsf1 thus promotes proteostasis and the regenerative activity of HSCs in response to culture stress and aging.
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The transcription factor HSF1, which promotes protein homeostasis by inducing many chaperone proteins, is necessary for protein homeostasis in HSCs during ageing.
“The transcription factor HSF1, which promotes protein homeostasis by inducing many chaperone proteins, is necessary for protein homeostasis in HSCs during ageing113.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [113]
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Heat-Shock Proteins in Leukemia and Lymphoma: Multitargets for Innovative Therapeutic Approaches
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PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal
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Translation is an emerging constraint on protein homeostasis in ageing
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Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
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Decoding functional hematopoietic progenitor cells in the adult human lung
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Temporal dynamics of TNF-mediated changes in hematopoietic stem cell function and recovery
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Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration
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Decoding functional hematopoietic progenitor cells in the adult human lungPreprint
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Self-citationE3 ubiquitin ligase on the biological properties of hematopoietic stem cell
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Role of Chaperone-Mediated Autophagy in Ageing Biology and Rejuvenation of Stem Cells
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Metabolic Alterations in HSCs during Aging and Leukemogenesis
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mRNA translational control of regeneration
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RNA helicase DDX21 sustains hematopoietic stem cell homeostasis by preventing nucleolar stress
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A protein synthesis brake for hematopoietic stem cell maintenancePreprint
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Small Molecules Targeting HSF1 Pathway: Chemical Strategies and Therapeutic Potential
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HSF1 in aging: The output selection model
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Current status of producing autologous hematopoietic stem cells
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Childhood hematopoietic stem cells constitute the permissive window for RUNX1-ETO leukemogenesis
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Expansion of human hematopoietic stem cells by inhibiting translationPreprint
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Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
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Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice
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Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis
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Acute and Chronic Tnf-α-Induced Effects on Hematopoietic Stem Cells are Fully ReversiblePreprint
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Functional haematopoietic progenitor cells in the adult human lungPreprint
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The Proteostasis Network is a Therapeutic Target in Acute Myeloid LeukemiaPreprint
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Self-citationAvoid shocking your hematopoietic stem cells to keep them young and growing
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Differentiation Latency and Dormancy Signatures Define Fetal Liver HSCs at Single Cell ResolutionPreprint
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UPS delivers apolarity and senescence to HSCs
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- Authors
- Kruta, M., Sunshine, M. J., Chua, B. A., Fu, Y., Chawla, A., Dillingham, C. H., Hidalgo San Jose, L., De Jong, B., Zhou, F. J., & Signer, R. A. J.
- Affiliations
- University of California San Diego (US)
- La Jolla Institute for Immunology (US)
- Corresponding author
- Signer, Robert A.J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 28
- Issue
- 11
- Pages
- 1950-1965.e6
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC8571035
- OpenAlex
- W3191440760
- Cited by
- 100
- References
- 97
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 15 · 2023: 27 · 2022: 16 · 2021: 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- American Society of Hematology
- Leukemia and Lymphoma Society
- National Institutes of Health
- University of California, San Diego
- National Cancer Institute (P30CA023100, S10 RR027366)
- Mark Foundation For Cancer Research
- V Foundation for Cancer Research (V2017-003)
- National Institute of Diabetes and Digestive and Kidney Diseases (8025-20, R01DK116951, R01DK124775)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- HSF1, hematopoietic stem cells, proteostasis, protein synthesis, stem cell aging, HSF1 activation, nuclear accumulation
- MeSH terms
- Proteostasis, Aging, Animals, Hematopoietic Stem Cells, Transcription Factors, Cellular Senescence, Mice
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