Freeman, Tom C

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity

Immune cells in cancerImmune Response and Inflammation

Cited by 2,210

Microglial brain region-dependent diversity and selective regional sensitivities to aging

Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 1,151

The systems biology graphical notation.

Novère, N. L., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., Demir, E., Wegner, K., Aladjem, M. I., Wimalaratne, S. M., et al. (2009) · Nature Biotechnology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 903

Gateways to the FANTOM5 promoter level mammalian expression atlas

Lizio, M., Harshbarger, J., Shimoji, H., Severin, J., Kasukawa, T., Sahin, S., Abugessaisa, I., Fukuda, S., Hori, F., Ishikawa-Kato, S., et al. (2015) · Genome Biology

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 871

Bovine Host Genetic Variation Influences Rumen Microbial Methane Production with Best Selection Criterion for Low Methane Emitting and Efficiently Feed Converting Hosts Based on Metagenomic Gene Abundance

Roehe, R., Dewhurst, R. J., Duthie, C.-A., Rooke, J. A., McKain, N., Ross, D. W., Hyslop, J. J., Waterhouse, A., Freeman, T. C., Watson, M., et al. (2016) · PLoS Genetics

Ruminant Nutrition and Digestive PhysiologyGenetic and phenotypic traits in livestock

Cited by 359

Construction, Visualisation, and Clustering of Transcription Networks from Microarray Expression Data

Freeman, T. C., Goldovsky, L., Brosch, M., van Dongen, S., Mazière, P., Grocock, R. J., Freilich, S., Thornton, J., & Enright, A. J. (2007) · PLoS Computational Biology

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 248

Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging

Chambers, E. S., Vukmanovic-Stejic, M., Shih, B. B., Trahair, H., Subramanian, P., Devine, O. P., Glanville, J., Gilroy, D., Rustin, M. H. A., Freeman, T. C., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 96

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease

Patir, A., Shih, B., McColl, B. W., & Freeman, T. C. (2019) · Glia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 90

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

Vincenti, J. E., Murphy, L., Grabert, K., McColl, B. W., Cancellotti, E., Freeman, T. C., & Manson, J. C. (2016) · Journal of Virology

Neuroinflammation and Neurodegeneration MechanismsPrion Diseases and Protein Misfolding

Cited by 88

Identification, comparison, and validation of robust rumen microbial biomarkers for methane emissions using diverse Bos taurus breeds and basal diets

Auffret, M. D., Stewart, R., Dewhurst, R. J., Duthie, C.-A., Rooke, J. A., Wallace, R. J., Freeman, T. C., Snelling, T. J., Watson, M., & Roehe, R. (2018) · Frontiers in Microbiology

Ruminant Nutrition and Digestive PhysiologyAnaerobic Digestion and Biogas Production

Cited by 82

Can DCs be distinguished from macrophages by molecular signatures?

Hume, D. A., Mabbott, N., Raza, S., & Freeman, T. C. (2013) · Nature Immunology

Immunotherapy and Immune ResponsesImmune cells in cancer

Cited by 69

Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation

Sherwin, J. R. A., Freeman, T. C., Stephens, R. J., Kimber, S., Smith, A. G., Chambers, I., Smith, S. K., & Sharkey, A. M. (2004) · Molecular Endocrinology

Reproductive System and PregnancyReproductive Biology and Fertility

Cited by 68