Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation

Sherwin, J. R. A.; Freeman, T. C.; Stephens, R. J.; Kimber, S.; Smith, A. G.; Chambers, I.; Smith, S. K.; Sharkey, A. M.

doi:10.1210/me.2004-0110

Cited by 68Reproductive System and PregnancyReproductive Biology and FertilityEstrogen and related hormone effects

Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation

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Sherwin, J. R. A., Freeman, T. C., Stephens, R. J., Kimber, S., Smith, A. G., Chambers, I., Smith, S. K., Sharkey, A. M.·2004·Molecular Endocrinology

DOI 10.1210/me.2004-0110

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Abstract

The endometrium is prepared for implantation by the actions of estradiol (E2) and progesterone (P4). In mice the luminal epithelium (LE) only becomes fully receptive to the attaching blastocyst in response to the nidatory estrogen surge on d 4 of pregnancy. The cytokine leukemia-inhibitory factor (LIF) is rapidly induced by nidatory estrogen and has been shown to be the primary mediator of its action. Implantation fails in the absence of LIF, and injection of LIF on d 4 of pregnancy can substitute for the nidatory estrogen. In this study, we sought to identify genes regulated by LIF in the uterine epithelium. We used oligonucleotide microarrays to compare the transcript profiles of paired uterine horns from LIF-deficient MF1 mice after intraluminal injection of LIF or PBS on d 4 of pseudopregnancy. IGF-binding protein 3 was identified as a gene up-regulated by LIF; this was confirmed by RT-PCR. In situ hybridization showed that the primary site of IGF-binding protein 3 expression is the luminal epithelium (LE), the known site of LIF action in the uterus. We identified two other genes: amphiregulin and immune response gene-1, the expression of which were also up-regulated by LIF. Immune response gene 1 has recently been shown to be essential for implantation. Expression of all three of these genes in the LE is known to be regulated by P4. The expression of osteoblast-specific factor 2 and leukocyte 12/15 lipoxygenase, which are also expressed in LE under the control of P4, were not increased by LIF. This suggests that one of the actions of LIF on LE may be to enhance the expression of a subset of P4-regulated genes.

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Accumulated fumarate can bind and inactivate reactive thiol residues of proteins and peptides in a process called succination.
“For instance, accumulated fumarate can bind and inactivate reactive thiol residues of proteins and peptides in a process called succination, a protein modification originally described in diabetes80.”
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Authors: Sherwin, J. R. A., Freeman, T. C., Stephens, R. J., Kimber, S., Smith, A. G., Chambers, I., Smith, S. K., & Sharkey, A. M.
Affiliations: University of Cambridge (GB)
Microarray Development Group (T.C.F., R.J.S.), United Kingdom Human Genome Mapping Project Resource Centre, Cambridge CB10 1SB
University of Manchester (GB)
University of Edinburgh (GB)
Corresponding author: Sherwin, J. R. A.
ORCID: Freeman, T. C.
Kimber, S.
Smith, A. G.
Chambers, I.
Smith, S. K.
Sharkey, A. M.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2004-09-01
Volume: 18
Issue: 9
Pages: 2185-2195
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2004-0110
OpenAlex: W2141628620
Cited by: 68
References: 44
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 1
FWCI: 2.16
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: leukemia inhibitory factor, implantation, endometrium, luminal epithelium, IGF binding protein-3, amphiregulin, progesterone, estradiol, pseudopregnancy, uterine transcriptome, cytokine signaling
MeSH terms: Animals, Endometrium, Estradiol, Female, Gene Expression Regulation, Glycoproteins, Hydro-Lyases, Embryo Implantation, Pregnancy, Progesterone, RNA, Messenger, Interleukin-6, Up-Regulation, In Situ Hybridization, Insulin-Like Growth Factor Binding Protein 3, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Intercellular Signaling Peptides and Proteins, Mice, Leukemia Inhibitory Factor, EGF Family of Proteins, Amphiregulin

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Identification of Genes Regulated by Leukemia-Inhibitory Factor in the Mouse Uterus at the Time of Implantation

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