Can DCs be distinguished from macrophages by molecular signatures?
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Macrophages and dendritic cells have similar transcriptomic profiles.
“Because macrophages and dendritic cells have similar transcriptomic profiles23–25, we repeated SingleR analysis using published RNA-seq datasets of mouse lung macrophages and dendritic cells26,27 to isolate the macrophages”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [26]
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Data from Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors
Nirmal, A. J., Regan, T. W., Shih, B. B.-J., Hume, D. A., Sims, A. H., & Freeman, T. C. (2023) · doi:10.1158/2326-6066.c.6548552.v1
Self-citation
- Authors
- Hume, D. A., Mabbott, N., Raza, S., & Freeman, T. C.
- Affiliations
- Roslin Institute (GB)
- Corresponding author
- Hume, David A
- Venue
- Nature Immunology
- Published
- 2013-02-15
- Volume
- 14
- Issue
- 3
- Pages
- 187-189
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2044789584
- Cited by
- 69
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 9 · 2012: 1
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-07-19)
- Open access
- closed
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BBS/E/D/05191131, BBS/E/D/20251969, BB/F019726/1, BBS/E/D/20231759, BBS/E/D/20211552, BB/G022607/1, BB/I001107/1)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- dendritic cells, macrophages, cell type discrimination, molecular signatures, transcriptomics, chickens, antigen-induced arthritis, dendritic cell subsets, stroke
- MeSH terms
- Cell Differentiation, Dendritic Cells, Humans, Transcription, Genetic, Cell Lineage
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