Wu, Joseph C.

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Cho, S., Discher, D. E., Leong, K. W., Vunjak-Novakovic, G., & Wu, J. C. (2022) · Nature Methods

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

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Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Matsa, E., Burridge, P. W., Yu, K.-H., Ahrens, J. H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J. M., et al. (2016) · Cell stem cell

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

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Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies

Tzatzalos, E., Abilez, O. J., Shukla, P., & Wu, J. C. (2016) · Advanced Drug Delivery Reviews

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

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Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans

Shen-Orr, S. S., Furman, D., Kidd, B. A., Hadad, F., Lovelace, P., Huang, Y.-W., Rosenberg-Hasson, Y., Mackey, S., Grisar, F. A. G., Pickman, Y., et al. (2016) · Cell Systems

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 154

Human induced pluripotent stem cell–derived cardiomyocytes as an in vitro model for coxsackievirus B3–induced myocarditis and antiviral drug screening platform

Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P. W., Rajarajan, K., Churko, J. M., Wu, H., Sallam, K. I., Matsa, E., Sturzu, A. C., et al. (2014) · Circulation Research

Viral Infections and Immunology ResearchPluripotent Stem Cells Research

Cited by 148

Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models

Wnorowski, A., Yang, H., & Wu, J. C. (2019) · Advanced Drug Delivery Reviews

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 124

Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., et al. (2020) · Science Translational Medicine

Pluripotent Stem Cells ResearchCardiomyopathy and Myosin Studies

Cited by 111

Human induced pluripotent stem cells as a platform for personalized and precision cardiovascular medicine

Matsa, E., Ahrens, J. H., & Wu, J. C. (2016) · Physiological Reviews

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 105

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

Katz, D. H., Tahir, U. A., Bick, A. G., Pampana, A., Ngo, D., Benson, M. D., Yu, Z., Robbins, J. M., Chen, Z.-Z., Cruz, D. E., et al. (2022) · Circulation

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 92

Telomere shortening is a hallmark of genetic cardiomyopathies

Chang, A. C. Y., Chang, A. C. H., Kirillova, A., Sasagawa, K., Su, W., Weber, G., Lin, J., Termglinchan, V., Karakikes, I., Seeger, T., et al. (2018) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCardiomyopathy and Myosin Studies

Cited by 91

Sex-Specific Cardiovascular Risks of Cancer and Its Therapies

Wilcox, N. S., Rotz, S. J., Mullen, M., Song, E. J., Ky Hamilton, B., Moslehi, J., Armenian, S. H., Wu, J. C., Rhee, J.-W., & Ky, B. (2022) · Circulation Research

Chemotherapy-induced cardiotoxicity and mitigationCardiac tumors and thrombi

Cited by 86

Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse

Yue, P., Arai, T., Terashima, M., Sheikh, A. Y., Cao, F., Charo, D., Hoyt, G., Robbins, R. C., Ashley, E. A., Wu, J., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiovascular Function and Risk FactorsCardiomyopathy and Myosin Studies

Cited by 81

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

Chang, A. C. Y., Ong, S.-G., LaGory, E. L., Kraft, P. E., Giaccia, A. J., Wu, J. C., & Blau, H. M. (2016) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceMuscle Physiology and Disorders

Cited by 81

Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome

Lau, E., Han, Y., Williams, D. R., Thomas, C. T., Shrestha, R., Wu, J. C., & Lam, M. P. Y. (2019) · Cell Reports

Advanced Proteomics Techniques and ApplicationsRNA Research and Splicing

Cited by 67

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology

Cardiovascular Health and Disease PreventionTelomeres, Telomerase, and Senescence

Cited by 59

Report of the National Heart, Lung, and Blood Institute Working Group on the Translation of Cardiovascular Molecular Imaging

Buxton, D. B., Antman, M., Danthi, N., Dilsizian, V., Fayad, Z. A., Garcia, M. J., Jaff, M. R., Klimas, M., Libby, P., Nahrendorf, M., et al. (2011) · Circulation

Cardiac Imaging and DiagnosticsMedical Imaging Techniques and Applications

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FDA Modernization Act 2.0 Paves the Way to Computational Biology and Clinical Trials in a Dish

Ahmed, S. M., Shivnaraine, R. V., & Wu, J. C. (2023) · Circulation

Animal testing and alternativesBiomedical Ethics and Regulation

Cited by 46

Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation

Hong, L., Zhang, M., Ly, O. T., Chen, H., Sridhar, A., Lambers, E., Chalazan, B., Youn, S.-W., Maienschein-Cline, M., Feferman, L., et al. (2021) · Stem Cell Reports

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Lam, C. K., Tian, L., Belbachir, N., Wnorowski, A., Shrestha, R., Ma, N., Kitani, T., Rhee, J.-W., & Wu, J. C. (2019) · Circulation Research

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

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Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons

Huang, C. Y., Nicholson, M. W., Wang, J. Y., Ting, C. Y., Tsai, M. H., Cheng, Y. C., Liu, C. L., Chan, D. Z. H., Lee, Y. C., Hsu, C. C., et al. (2022) · Cell Reports

Pluripotent Stem Cells ResearchAnimal testing and alternatives

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The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment

Abi-Gerges, N., McMahon, C., Vargas, H., Sager, P., Chui, R., Stevens, D., Davila, J., Schaub, J. R., Wu, J. C., del Rio, C., et al. (2019) · Journal of Pharmacological and Toxicological Methods

Animal testing and alternativesCardiac electrophysiology and arrhythmias

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