Zelcer, Noam

Liver X receptors as integrators of metabolic and inflammatory signaling

Zelcer, N. (2006) · Journal of Clinical Investigation

Cholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Cited by 978

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 876

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

Zelcer, N., Hong, C., Boyadjian, R., & Tontonoz, P. (2009) · Science

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 848

LXR signaling couples sterol metabolism to proliferation in the acquired immune response

Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 711

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

Zelcer, N., Khanlou, N., Clare, R., Jiang, Q., Reed-Geaghan, E. G., Landreth, G. E., Vinters, H. V., & Tontonoz, P. (2007) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 358

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Bogie, J. F. J., Grajchen, E., Wouters, E., Corrales, A. G., Dierckx, T., Vanherle, S., Mailleux, J., Gervois, P., Wolfs, E., Dehairs, J., et al. (2020) · Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 151

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2

Hong, C., Duit, S., Jalonen, P., Out, R., Scheer, L., Sorrentino, V., Boyadjian, R., Rodenburg, K. W., Foley, E., Korhonen, L., et al. (2010) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 142

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation

Pietiäinen, V., Vassilev, B., Blom, T., Wang, W., Nelson, J., Bittman, R., Bäck, N., Zelcer, N., & Ikonen, E. (2013) · Journal of Cell Science

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 89

Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists

Scotti, E., Hong, C., Yoshinaga, Y., Tu, Y., Hu, Y., Zelcer, N., Boyadjian, R., de Jong, P. J., Young, S. G., Fong, L. G., et al. (2011) · Molecular and Cellular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 77

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Sorrentino, V., Nelson, J. K., Maspero, E., Marques, A. R. A., Scheer, L., Polo, S., & Zelcer, N. (2013) · Journal of Lipid Research

Cholesterol and Lipid MetabolismCellular transport and secretion

Cited by 68

The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans

Weissglas-Volkov, D., Calkin, A. C., Tusie-Luna, T., Sinsheimer, J. S., Zelcer, N., Riba, L., Tino, A. M. V., Ordoñez-Sánchez, M. L., Cruz-Bautista, I., Aguilar-Salinas, C. A., et al. (2011) · Journal of Clinical Investigation

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 66

(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis

Ren, L., Sun, Y., Lu, H., Ye, D., Han, L., Wang, N., Daugherty, A., Li, F., Wang, M., Su, F., et al. (2018) · Circulation Research

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 59

Distinct Functional Domains Contribute to Degradation of the Low Density Lipoprotein Receptor (LDLR) by the E3 Ubiquitin Ligase Inducible Degrader of the LDLR (IDOL)

Sorrentino, V., Scheer, L., Santos, A., Reits, E., Bleijlevens, B., & Zelcer, N. (2011) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismUbiquitin and proteasome pathways

Cited by 53

The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL

Nelson, J. K., Sorrentino, V., Avagliano Trezza, R., Heride, C., Urbe, S., Distel, B., & Zelcer, N. (2016) · Circulation Research

Ubiquitin and proteasome pathwaysCholesterol and Lipid Metabolism

Cited by 51

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 51

Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism

Lu, X., Meima, M. E., Nelson, J. K., Sorrentino, V., Loregger, A., Scheij, S., Dekkers, D. H. W., Mulder, M. T., Demmers, J. A. A., M-Dallinga-Thie, G., et al. (2016) · Circulation Research

Renin-Angiotensin System StudiesCholesterol and Lipid Metabolism

Cited by 48

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes

Loregger, A., Cook, E. C. L., Nelson, J. K., Moeton, M., Sharpe, L. J., Engberg, S., Karimova, M., Lambert, G., Brown, A. J., & Zelcer, N. (2016) · Molecular and Cellular Biology

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 48

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Hendrix, S., Kingma, J., Ottenhoff, R., Valiloo, M., Svecla, M., Zijlstra, L. F., Sachdev, V., Kovac, K., Levels, J. H. M., Jongejan, A., et al. (2023) · Nature Communications

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 34

The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms

Ndoj, K., Meurs, A., Papaioannou, D., Bjune, K., & Zelcer, N. (2025) · Atherosclerosis

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 17

SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P

Hendrix, S., Tan, J. M. E., Ndoj, K., Kingma, J., Valiloo, M., Zijlstra, L. F., Ottenhoff, R., Seidah, N. G., Loregger, A., Kober, D. L., et al. (2024) · Molecular and Cellular Biology

Sphingolipid Metabolism and SignalingLipid metabolism and biosynthesis

Cited by 9

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis

Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 1