Cowen, Leah E.

Hsp90 orchestrates stress response signaling governing fungal drug resistance

Cowen, L. E. (2009) · PLoS Pathogens

Heat shock proteins researchAntifungal resistance and susceptibility

Cited by 130

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

Robbins, N., Leach, M. D., & Cowen, L. E. (2012) · Cell Reports

Heat shock proteins researchFungal and yeast genetics research

Cited by 126

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Whitesell, L., Robbins, N., Huang, D. S., McLellan, C. A., Shekhar-Guturja, T., LeBlanc, E. V., Nation, C. S., Hui, R., Hutchinson, A., Collins, C., et al. (2019) · Nature Communications

Heat shock proteins researchAntifungal resistance and susceptibility

Cited by 124

Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry

Diezmann, S., Michaut, M., Shapiro, R. S., Bader, G. D., & Cowen, L. E. (2012) · PLoS Genetics

Heat shock proteins researchFungal and yeast genetics research

Cited by 112

Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs

Leach, M. D., Klipp, E., Cowen, L. E., & Brown, A. J. P. (2012) · Nature Reviews Microbiology

Heat shock proteins researchFungal and yeast genetics research

Cited by 107

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

Shekhar-Guturja, T., Gunaherath, G. M. K. B., Wijeratne, E. M. K., Lambert, J.-P., Averette, A. F., Lee, S. C., Kim, T., Bahn, Y.-S., Tripodi, F., Ammar, R., et al. (2016) · Nature Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 101

Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations

Hill, J. A., Ammar, R., Torti, D., Nislow, C., & Cowen, L. E. (2013) · PLoS Genetics

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 93

The Hsp90 chaperone network modulates Candida virulence traits

O’Meara, T. R., Robbins, N., & Cowen, L. E. (2017) · Trends in Microbiology

Heat shock proteins researchFungal and yeast genetics research

Cited by 92

The role of Candida albicans stress response pathways in antifungal tolerance and resistance

Iyer, K. R., Robbins, N., & Cowen, L. E. (2022) · iScience

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 88

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

Shapiro, R. S., Zaas, A. K., Betancourt-Quiroz, M., Perfect, J. R., & Cowen, L. E. (2012) · PLoS ONE

Fungal and yeast genetics researchHeat shock proteins research

Cited by 86

Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by High Temperature or Hsp90 Compromise

Shapiro, R. S., Sellam, A., Tebbji, F., Whiteway, M., Nantel, A., & Cowen, L. E. (2012) · Current Biology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 81

Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations

Hill, J. A., O’Meara, T. R., & Cowen, L. E. (2015) · Cell Reports

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 80

Using Combination Therapy to Thwart Drug Resistance

Hill, J. A., & Cowen, L. E. (2015) · Future Microbiology

Antibiotic Resistance in BacteriaAntibiotic Use and Resistance

Cited by 75

Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans

Senn, H., Shapiro, R. S., & Cowen, L. E. (2012) · Molecular Biology of the Cell

Fungal and yeast genetics researchHeat shock proteins research

Cited by 67

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Xie, J. L., Qin, L., Miao, Z., Grys, B. T., Diaz, J. D. L. C., Ting, K., Krieger, J. R., Tong, J., Tan, K., Leach, M. D., et al. (2017) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 60

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2

Caplan, T., Lorente-Macías, Á., Stogios, P. J., Evdokimova, E., Hyde, S., Wellington, M. A., Liston, S., Iyer, K. R., Puumala, E., Shekhar-Guturja, T., et al. (2020) · Cell Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 57

Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans

Caplan, T., Polvi, E. J., Xie, J. L., Buckhalter, S., Leach, M. D., Robbins, N., & Cowen, L. E. (2018) · Cell Reports

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 56

Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space

Veri, A. O., Miao, Z., Shapiro, R. S., Tebbji, F., O’Meara, T. R., Kim, S. H., Colazo, J., Tan, K., Vyas, V. K., Whiteway, M., et al. (2018) · PLoS Genetics

Fungal and yeast genetics researchHeat shock proteins research

Cited by 51

Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen

O’Meara, T. R., O’Meara, M. J., Polvi, E. J., Pourhaghighi, M. R., Liston, S. D., Lin, Z.-Y., Veri, A. O., Emili, A., Gingras, A.-C., & Cowen, L. E. (2019) · PLoS Biology

Heat shock proteins researchFungal and yeast genetics research

Cited by 49

Hsp90-dependent regulatory circuitry controlling temperature-dependent fungal development and virulence: Hsp90 and fungal development

O'Meara, T. R., & Cowen, L. E. (2014) · Cellular Microbiology

Fungal and yeast genetics researchHeat shock proteins research

Cited by 48

Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

Marcyk, P. T., LeBlanc, E. V., Kuntz, D. A., Xue, A., Ortiz, F., Trilles, R., Bengtson, S., Kenney, T. M. G., Huang, D. S., Robbins, N., et al. (2021) · Journal of Medicinal Chemistry

Heat shock proteins researchFungal Infections and Studies

Cited by 40

Metabolic control of antifungal drug resistance

Robbins, N., Collins, C., Morhayim, J., & Cowen, L. E. (2010) · Fungal Genetics and Biology

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 40

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 34

Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III

Di Trani, J. M., Liu, Z., Whitesell, L., Brzezinski, P., Cowen, L. E., & Rubinstein, J. L. (2022) · Structure

Enzyme Structure and FunctionMitochondrial Function and Pathology

Cited by 32