Using Combination Therapy to Thwart Drug Resistance

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Sampling the Antibiotic Resistome

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Humans as the World's Greatest Evolutionary Force

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Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

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Activated ClpP kills persisters and eradicates a chronic biofilm infection

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Systems biology and combination therapy in the quest for clinical efficacy

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Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

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Evaluating treatment protocols to prevent antibiotic resistance

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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

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The mutant selection window and antimicrobial resistance

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Antibiotic interactions that select against resistance

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Lack of development of new antimicrobial drugs: a potential serious threat to public health

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Functional classification of drugs by properties of their pairwise interactions

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Drug interactions and the evolution of antibiotic resistance

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Accelerated evolution of resistance in multidrug environments

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Lack of development of new antimicrobial drugs: a potential serious threat to public health

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When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

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Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

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Combination chemical genetics

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Optimal Drug Synergy in Antimicrobial Treatments

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Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations

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The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens

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Combination antifungal therapy: a critical review of the evidence

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Advancing the development of tuberculosis therapy

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Twenty-Five Years of Translational Medicine in Antiretroviral Therapy: Promises to Keep

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Molecular Evolution of Antifungal Drug Resistance

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Antifungal Drugs: The Current Armamentarium and Development of New Agents

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Immune defence to invasive fungal infections: A comprehensive review

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Combinatorial strategies for combating invasive fungal infections

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New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

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Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms

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Biological challenges of phage therapy and proposed solutions: a literature review

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Cyclodextrins in drug delivery: applications in gene and combination therapy

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Development and research progress of anti-drug resistant fungal drugs

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Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance

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Phytochemicals with activity against methicillin-resistant Staphylococcus aureus

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High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

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Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes

Qadri, H., Shah, A. H., & Mir, M. A. (2020) · Current Drug Targets · doi:10.2174/1389450121666201228123212 · Cited by 64 · see citing works

Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis

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The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways

Shivarathri, R., Tscherner, M., Zwolanek, F., Singh, N. K., Chauhan, N., & Kuchler, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-45817-5 · Cited by 58 · see citing works

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans

Li, C., Tu, J., Han, G., Liu, N., & Sheng, C. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113961 · Cited by 60 · see citing works

Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review

Rabaan, A. A., Sulaiman, T., Al-Ahmed, S. H., Buhaliqah, Z. A., Buhaliqah, A. A., AlYuosof, B., Alfaresi, M. S., Fares, M. A. A., Alwarthan, S. M., Alkathlan, M. S., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12030608 · Cited by 53 · see citing works

Bicyclic Boronate β‐Lactamase Inhibitors: The Present Hope against Deadly Bacterial Pathogens

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Key Considerations during the Transition from the Acute Phase of the COVID-19 Pandemic: A Narrative Review

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Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins

Kuan, S. L., Fischer, S., Häfner, S., Wang, T., Syrovets, T., Liu, W., Tokura, Y., Ng, D. Y. W., Riegger, A., Förtsch, C., et al. (2018) · Advanced Science · doi:10.1002/advs.201701036 · Cited by 30 · see citing works

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

Almeida‐Silva, J., Menezes, D., Fernandes, J. M. P., de Almeida, M. C., Vasco-dos-Santos, D. R., Saraiva, R. M., Viçosa, A. L., Perez, S. A. C., Andrade, S. G., Suarez-Fontes, A. M., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.926699 · Cited by 28 · see citing works

Teicoplanin – Tigecycline Combination Shows Synergy Against Mycobacterium abscessus

Aziz, D. B., Teo, J. W. P., Dartois, V. A., & Dick, T. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00932 · Cited by 27 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch44 · Cited by 26 · see citing works

Target identification and assessment in the era of AI

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Synergistic Response of Rifampicin with Hydroperoxides on Mycobacterium: A Mechanistic Study

Patel, Y. S., & Mehra, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02075 · Cited by 22 · see citing works

The combination of Neosartorya (Aspergillus) fischeri antifungal proteins with rationally designed γ-core peptide derivatives is effective for plant and crop protection

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Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates

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Developing an Agent-Based Drug Model to Investigate the Synergistic Effects of Drug Combinations

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Recent Status and Advancements in the Development of Antifungal Agents: Highlights on Plant and Marine Based Antifungals

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Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i>

Salama, E. A., Elgammal, Y., Wijeratne, A., Lanman, N. A., Utturkar, S. M., Farhangian, A., Li, J., Meunier, B., Hazbun, T. R., & Seleem, M. N. (2024) · Emerging Microbes &amp; Infections · doi:10.1080/22221751.2024.2322649 · Cited by 16 · see citing works

Synergy between Florfenicol and Aminoglycosides against Multidrug-Resistant Escherichia coli Isolates from Livestock

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Design, synthesis and biological evaluation of VEGFR-2/HDAC dual inhibitors as multitargeted antitumor agents based on fruquintinib and vorinostat

Gao, Y., Li, F., Ni, X., Yang, S., Liu, H., Wu, X., Liu, J., & Ma, J. (2023) · RSC Advances · doi:10.1039/d3ra05542f · Cited by 16 · see citing works

In vitro antidermatophytic synergism of double and triple combination of clioquinol with ciclopirox and terbinafine

da Costa, B. S., Pippi, B., Kaminski, T. F. A., de Andrade, S. F., & Fuentefría, A. M. (2020) · Mycoses · doi:10.1111/myc.13127 · Cited by 16 · see citing works

High-throughput identification of the sensitivities of an Escherichia coli ΔrecA mutant strain to various chemical compounds

Maeda, T., Horinouchi, T., Sakata, N., Sakai, A., & Furusawa, C. (2019) · The Journal of Antibiotics · doi:10.1038/s41429-019-0160-5 · Cited by 15 · see citing works

Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens

Kim, S. H., Liu, C., Zhou, Y., Zhang, Y., McGregor, C., Steere, L., Frederick, B. H., Liu, C. T., Whitesell, L. J., & Cowen, L. E. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.0c00290 · Cited by 14 · see citing works

Novel bioactive cationic cubosomes enhance the cytotoxic effect of paclitaxel against a paclitaxel resistant prostate cancer cell-line

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The hidden threat: Unveiling the rise of antifungal drug resistance

Chaudhary, R., & Thakur, Z. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108068 · Cited by 12 · see citing works

Antimicrobial and Antibiofilm Activity of Monolaurin against Methicillin‐Resistant Staphylococcus aureus Isolated from Wound Infections

Gany, S. S. H. A. E., Azmy, A. F., EL-Gendy, A. O., El-Baky, R. M. A., Mustafa, A., Abourehab, M. A. S., El‐Beeh, M. E., & Ibrahim, R. A. (2024) · International Journal of Microbiology · doi:10.1155/2024/7518368 · Cited by 11 · see citing works

Clorgyline Analogs Synergize with Azoles against Drug Efflux in Candida auris

Toepfer, S., Lackner, M., Keniya, M. V., Zenz, L.-M., Friemert, M., Bracher, F., & Monk, B. C. (2023) · Journal of Fungi · doi:10.3390/jof9060663 · Cited by 10 · see citing works

Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation

Boonhok, R., Sangkanu, S., Phumjan, S., Jongboonjua, R., Sangnopparat, N., Kwankaew, P., Tedasen, A., Lim, C. L., Pereira, M. D. L., Rahmatullah, M., et al. (2022) · PeerJ · doi:10.7717/peerj.13657 · Cited by 9 · see citing works

Nanoparticle-based Olaparib delivery enhances its effect, and improves drug sensitivity to cisplatin in triple negative breast cancer

Zhang, S., Li, E., Liu, Z., Shang, H., Chen, Y., & Jing, H. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103731 · Cited by 7 · see citing works

Insight into the Antibacterial Action of Iodinated Imine, an Analogue of Rafoxanide: a Comprehensive Study of Its Antistaphylococcal Activity

Krátký, M., Konečná, K., Janďourek, O., Diepoltová, A., Vávrová, P., Voxová, B., Vejsová, M., Bárta, P., & Bősze, S. E. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03064-22 · Cited by 6 · see citing works

A call to arms: Unifying the fight against resistance

Kaushansky, A., Hedstrom, L., Goldman, A. J., Singh, J., Yang, P. L., Rathod, P. K., Cynamon, M. H., Wodarz, D., Mahadevan, D., Tomaras, A. P., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aav0442 · Cited by 6 · see citing works

Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans

Wu, Y., Jiang, L., Liu, R., Yang, L., Zou, F., Zhang, T.-Y., Fan, Z., Zhang, T., Yang, H., Yin, S., et al. (2024) · Medicinal Chemistry Research · doi:10.1007/s00044-024-03270-8 · Cited by 5 · see citing works

Inhibition of SARS-CoV-2 Mpro with Vitamin C, L-Arginine and a Vitamin C/L-Arginine Combination

Đukić, I., Kaličanin, N., Senćanski, M., Pajović, S. B., Milićević, J. S., Prljic, J., Paessler, S., Prodanović, R., & Glišić, S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2801008 · Cited by 4 · see citing works

Powering up antifungal treatment: using small molecules to unlock the potential of existing therapies

Shapiro, R. S., & Gerstein, A. C. (2023) · mBio · doi:10.1128/mbio.01073-23 · Cited by 4 · see citing works

Synergy Over Monotherapy

Ježíková, Z., Pagáč, T., Víglaš, J., Pfeiferová, B., Šoltýs, K., Bujdáková, H., Černáková, L., & Olejníková, P. (2019) · Current Microbiology · doi:10.1007/s00284-019-01678-9 · Cited by 4 · see citing works

Antifungal effects of andrographolide and its combination with amphotericin B against selected fungal pathogens

Dafur, G. S., Kub, T. N. T., Singh, K. K. B., Harun, A. B., Lambuk, F., Mohamud, R., Kadir, R., Ismail, N., & Yusop, N. (2025) · PeerJ · doi:10.7717/peerj.19544 · Cited by 3 · see citing works

Lippia sidoides essential oil against Candida auris and Candida albicans – A promising strategy for antifungal activity in the context of oral candidiasis

Araujo, G. S., de Jesus, I. C. T. A., da Costa, P. C. Q. G., Marques, K. K. G., Gonçalves, J. C. R., & de Castro, R. D. (2026) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2026.106572 · Cited by 3 · see citing works

The Challenge of Resistance in Antimicrobial Drug Development

Anderson, A. C., & Wright, D. L. (2015) · Future Microbiology · doi:10.2217/fmb.15.75 · Cited by 2 · see citing works

Reply to: Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection

Lyras, D., Srikhanta, Y. N., & McGowan, S. (2020) · Nature Microbiology · doi:10.1038/s41564-019-0662-8 · Cited by 2 · see citing works

Triazine amine compounds synergistically enhance the efficacy against fluconazole-resistant Candida albicans with fluconazole by inhibiting cell wall synthesis

Jiang, L., Yang, L., Yang, L., Yang, B., Xing, L., Liu, J., Yan, R., Han, J., Li, G., & Wang, R. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117181 · Cited by 1 · see citing works

Nanoliposome mediated co-delivery of amoxicillin and tazobactam remediate intracellular infection by a multidrug-resistant Salmonella enterica serovar Typhimurium

Sackey, T., Kannan, U., Majumder, S., John, J., Viau, C., Feng, Z., Benoit‐Biancamano, M., Ronholm, J., & George, S. (2026) · The Journal of Antibiotics · doi:10.1038/s41429-026-00903-5 · Cited by 1 · see citing works

Host Immune Responses to Pathogenic Fungi and Contemporary Therapeutic Strategies

Shallal, A. F., Razaq, C. H., Ahmed, A. S., Ahmed, S. S., Eyüpoğlu, V., & Salman, R. S. (2026) · Journal of Mycology and Truffle · doi:10.65999/mycotruffle.2026.26 · Cited by 1 · see citing works

Laboratory Investigations and Result Interpretation

Nedbalcová, K., & Pokludová, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-46721-0_8 · Cited by 1 · see citing works

Functional Genomic and Chemical Biology Analysis of Echinocandin Resistance in Candida albicans

Caplan, T. (2018) · TSpace (University of Toronto) · Cited by 1 · see citing works

Survival of the “unfittest”: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitnessPreprint

Carolus, H., Biriukov, V. V., Vreys, J., Romero, C. L., Avila, J. P. H., Vergauwen, R., Sofras, D., Vanreppelen, G., Vinken, L., Xavier, B. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.05.636719 · Cited by 1 · see citing works

Targeting Casein Kinases in the Fungal Pathogen Candida albicans

Hyde, S. (2020) · TSpace (University of Toronto)

In vivo Chemosuppressive effects of Combinations of Three Nigerian Ethnomedicinal Antimalarial Plants

Odediran, S. A., Ehigie, A. F., Akadiri, S. O., Bamikole, R. A., Adeniyi, R., Adeoti, R., & Aladesanmi, J. A. (2022) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2022/v33i230449

Combinatorial approach to combat drug resistance in human pathogenic fungi

Mir, M. A., Qadri, H., Aisha, S., & Shah, A. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96127-1.00011-5

Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning

Vannier-Santos, M. A., Suarez-Fontes, A. M., Almeida‐Silva, J., Viçosa, A. L., Perez, S. A. C., Hasslocher‐Moreno, A. M., da Silveira, G. P. E., Portela, L. F., & Saraiva, R. M. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104231

Peer Review #1 of "Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation (v0.2)"

(2022) · PeerJ · doi:10.7287/peerj.13657v0.2/reviews/1

Peer Review #2 of "Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13657v0.1/reviews/2

Peer Review #1 of "Curcumin effect on Acanthamoeba triangularis encystation under nutrient starvation (v0.1)"

(2022) · PeerJ · doi:10.7287/peerj.13657v0.1/reviews/1

Multidrug resistance to fluconazole, amphotericin B and antiseptic miramistin in Candida spp. isolated from patients with various pathology in region of Crimea

Криворутченко, Ю. Л., Кirsanova, M. A., Postnikova, O., Andronovskaja, I., & Sheiko, E. (2021) · Immunopathology Allergology Infectology · doi:10.14427/jipai.2021.3.79

Synergistic Combination of Amphotericin B and Antiseptic Miramistin May Be Effective in the Fight Against Drug-Resistant Isolates of Candida Fungi

Кirsanova, M. A., Криворутченко, Ю. Л., Postnikova, O. N., & Andronovskaia, I. B. (2022) · Antibiot Khimioter = Antibiotics and Chemotherapy · doi:10.37489/0235-2990-2022-67-9-10-25-34

Novel Strategies for Combating Antimicrobial Resistance: Alternative Agents on the Horizon

Navales, I. A. M., Paglas, M. A., Panibon, R., Parcasio, R. D., Parcon, A. B., Pascua, L. L., Patadon, S. O. S., & Padilla, J. (2023) · International Journal of Research Publication and Reviews · doi:10.55248/gengpi.4.1223.123551

Lippia thymoides essential oils activity against Candida species from HIV+ individual oral lesionsPreprint

de Azevedo, F. O., de Oliveira, A. P. R. S., de Farias, A. P. F., Santos, R. P. B., de Oliveira, Y. A., Falcão, M. M. L., Gomes‐Filho, I. S., Angélica, M., Kusterer, L. L., Sarmento, V. A., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4263276/v1

Combined activity of blue vitriol, brimstone and black stone on clinical Candida species isolates using fractional inhibitory concentration Index

Udemezue, O. I., Uba, C. C., Udemezue, O. I., Udenweze, E. C., Ezeadila, J. O., & Ezenwelu, C. O. (2024) · International Journal of Biological and Pharmaceutical Sciences Archive · doi:10.53771/ijbpsa.2024.7.2.0040

Essential oils from Lippia thymoides: insights into their antifungal activity against Candida species from oral lesions of HIV+ individuals

de Azevedo, F. O., de Oliveira, A. P. R. S., de Farias, A. P. F., Santos, R. P. B., de Oliveira, Y. A., Falcão, M. M. L., Gomes‐Filho, I. S., Lucchese, A. M., Lins-Kusterer, L., Sarmento, V. A., et al. (2025) · Caderno Pedagógico · doi:10.54033/cadpedv22n10-270

Anti-psychotic drugs act synergistically in combination with antifungal drugs to inhibit drug-resistant Cryptococcus and Candida speciesPreprint

Ayala, M., Jakamartana, A., Costa, R. M. D. S., Bednarek, J. M., Moreau, C. T., Cheung, C. K., & Brown, J. C. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.31.697249

Neuroprotective effects of pretreatment with fucoidan and ruthenium red in rats exposed to ischemic stroke injury

Moradpour, F., Javanmardi, S., Omidian, N., Kavyannejad, R., & Mohammadian, M. (2026) · Brain Injury · doi:10.1080/02699052.2026.2616381

Drug combinations: A strategy to extend the life of antimicrobials

Monteiro, K. L. C., Freire, N. M. L., de Aquino, T. M., & Silva-Júnior, E. F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36518-8.00003-5

Urosepsis by multidrug-resistant Nakaseomyces glabratus with non-functional Erg3 and Erg11—do collateral sensitivity and a unique mode of action make nitroxoline a viable UTI antifungal?

Carolus, H., Biriukov, V. V., Vreys, J., Romero, C. L., Ávila, J. P. H., Vergauwen, R., Sofras, D., Nysten, J. V., Vanreppelen, G., Vinken, L., et al. (2026) · mBio · doi:10.1128/mbio.00588-26

Anti-psychotic drugs act synergistically in combination with antifungal drugs to inhibit drug-resistant Cryptococcus neoformans and Candida albicans

Ayala, M., Jakamartana, A., Costa, R. M. D. S., Cheung, E. C.-K., Bednarek, J. M., Moreau, C. T., & Brown, J. C. S. (2026) · mSphere · doi:10.1128/msphere.00432-26

BindingDB Entry 50017067: Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.

BindingDB (2023) · UC San Diego · doi:10.7270/q2ng4vqm

BindingDB Entry 50012359: Novel Carboline Fungal Histone Deacetylase (HDAC) Inhibitors for Combinational Treatment of Azole-Resistant Candidiasis.

BindingDB (2022) · UC San Diego · doi:10.7270/q2pr80nz

Drug combinations: A strategy to extend the life of antimicrobials

Monteiro, K. L. C., Freire, N. M. L., de Aquino, T. M., & Silva-Júnior, E. F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36518-8.00003-5

Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions

Morales‐Durán, N., León‐Buitimea, A., & Morones‐Ramírez, J. R. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27984 · Cited by 71 · see citing works

Can Combination Therapy Overcome Drug Resistance?

Cohen, J. (1993) · Science · doi:10.1126/science.7684162 · Cited by 5 · see citing works

Leveraging laboratory and clinical studies to design effective antibiotic combination therapy

Davis, K. P., Greenstein, T., Viau, R. A., & Aldridge, B. B. (2021) · Current Opinion in Microbiology · doi:10.1016/j.mib.2021.09.006 · Cited by 13 · see citing works

Synergistic Effects of Combination Therapies Overcoming Drug Resistance

Kumar, R., Karmakar, R., & Zebda, I. (2026) · Springer eBooks · doi:10.1007/978-981-92-0477-9_18