Cowen, Leah E.

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 801

Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi

Cowen, L. E., & Lindquist, S. (2005) · Science

Heat shock proteins researchEvolution and Genetic Dynamics

Cited by 698

Mechanisms of Antifungal Drug Resistance

Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 647

Regulatory circuitry governing fungal development, drug resistance, and disease.

Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 576

Molecular Evolution of Antifungal Drug Resistance

Robbins, N., Caplan, T., & Cowen, L. E. (2017) · Annual Review of Microbiology

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 441

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences

Antifungal resistance and susceptibilityHeat shock proteins research

Cited by 413

Treatment strategies for cryptococcal infection: challenges, advances and future outlook

Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021) · Nature Reviews Microbiology

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 363

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 362

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 329

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

Selmecki, A. M., Dulmage, K., Cowen, L. E., Anderson, J. B., & Berman, J. (2009) · PLoS Genetics

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 319

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

Shapiro, R. S., Uppuluri, P., Zaas, A. K., Collins, C., Senn, H., Perfect, J. R., Heitman, J., & Cowen, L. E. (2009) · Current Biology

Fungal and yeast genetics researchHeat shock proteins research

Cited by 311

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

Cowen, L. E. (2008) · Nature Reviews Microbiology

Heat shock proteins researchFungal and yeast genetics research

Cited by 311

Molecular mechanisms governing antifungal drug resistance

Lee, Y., Robbins, N., & Cowen, L. E. (2023) · npj Antimicrobials and Resistance

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 304

Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms

Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 291

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Cowen, L. E., & Steinbach, W. J. (2008) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 285

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 271

Global analysis of fungal morphology exposes mechanisms of host cell escape

O’Meara, T. R., Veri, A. O., Ketela, T., Jiang, B., Roemer, T., & Cowen, L. E. (2015) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 243

Evolution of Drug Resistance in Experimental Populations of Candida albicans

Cowen, L. E., Sanglard, D., Calabrese, D., Sirjusingh, C., Anderson, J. B., & Kohn, L. M. (2000) · Journal of Bacteriology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 207

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata

Singh-Babak, S. D., Babak, T., Diezmann, S., Hill, J. A., Xie, J. L., Chen, Y.-L., Poutanen, S. M., Rennie, R. P., Heitman, J., & Cowen, L. E. (2012) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 205

Genetic Architecture of Hsp90-Dependent Drug Resistance

Cowen, L. E., Carpenter, A. E., Matangkasombut, O., Fink, G. R., & Lindquist, S. (2006) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 159

Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae

Anderson, J. B., Sirjusingh, C., Parsons, A. B., Boone, C., Wickens, C., Cowen, L. E., & Kohn, L. M. (2003) · Genetics

Evolution and Genetic DynamicsFungal and yeast genetics research

Cited by 156

Evolution of Drug Resistance in Candida Albicans

Cowen, L. E., Anderson, J. B., & Kohn, L. M. (2002) · Annual Review of Microbiology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 151

Population genomics of drug resistance in Candida albicans

Cowen, L. E., Nantel, A., Whiteway, M. S., Thomas, D. Y., Tessier, D. C., Kohn, L. M., & Anderson, J. B. (2002) · Proceedings of the National Academy of Sciences

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 140

Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance

Kim, S. H., Iyer, K. R., Pardeshi, L., Muñoz, J. F., Robbins, N., Cuomo, C. A., Wong, K. H., & Cowen, L. E. (2019) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 136