Leeman, Dena S.

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 543

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science

Neurogenesis and neuroplasticity mechanismsAutophagy in Disease and Therapy

Cited by 528

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 521

Single-cell transcriptomic analysis defines heterogeneity and transcriptional dynamics in the adult neural stem cell lineage

Dulken, B. W., Leeman, D. S., Boutet, S. C., Hebestreit, K., & Brunet, A. (2017) · Cell Reports

Neurogenesis and neuroplasticity mechanismsSingle-cell and spatial transcriptomics

Cited by 334

FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis

Webb, A. E., Pollina, E. A., Vierbuchen, T., Urbán, N., Ucar, D., Leeman, D. S., Martynoga, B., Sewak, M., Rando, T. A., Guillemot, F., et al. (2013) · Cell Reports

FOXO transcription factor regulationNeurogenesis and neuroplasticity mechanisms

Cited by 164