Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
Open accessAbstract
The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family, but less is known about the role of other histone modifications in longevity. Histone methylation has a crucial role in development and in maintaining stem cell pluripotency in mammals. Regulators of histone methylation have been associated with ageing in worms and flies, but characterization of their role and mechanism of action has been limited. Here we identify the ASH-2 trithorax complex, which trimethylates histone H3 at lysine 4 (H3K4), as a regulator of lifespan in Caenorhabditis elegans in a directed RNA interference (RNAi) screen in fertile worms. Deficiencies in members of the ASH-2 complex-ASH-2 itself, WDR-5 and the H3K4 methyltransferase SET-2-extend worm lifespan. Conversely, the H3K4 demethylase RBR-2 is required for normal lifespan, consistent with the idea that an excess of H3K4 trimethylation-a mark associated with active chromatin-is detrimental for longevity. Lifespan extension induced by ASH-2 complex deficiency requires the presence of an intact adult germline and the continuous production of mature eggs. ASH-2 and RBR-2 act in the germline, at least in part, to regulate lifespan and to control a set of genes involved in lifespan determination. These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Too much H3K4me3 tracks with an aged epigenome.
“For example, the ASH-2 trithorax complex mediates trimethylation of histone H3 on Lys4 (H3K4me3), and its deletion increases Caenorhabditis elegans lifespan, consistent with excessive H3K4me3 being associated with an aging epigenome172,173.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [172]
In C. elegans, knockdown of H3K4 methyltransferase SETD1A/SET-2 increases lifespan.
“In C. elegans, knockdown of the H3K4 methyltransferase SETD1A/SET-2 increases lifespan (Greer et al., 2010).”
From The Aging Epigenome (2016) · cites this paper as Greer et al., 2010
Knockdown of H3K4me3 demethylase KDM5B/RBR-2 in C. elegans hermaphrodites and Drosophila males shortens lifespan.
“Consistent with the idea that loss of H3K4me3 is beneficial to longevity, knockdown of the H3K4me3 demethylase KDM5B/RBR-2 in C. elegans hermaphrodites and Drosophila males shortens lifespan (Greer et al., 2010; Li et al., 2010).”
From The Aging Epigenome (2016) · cites this paper as Greer et al., 2010
Knockdown of H3K4me3 enzymes can both increase and decrease lifespan depending on enzyme or context.
“Like the H3K27me3 modifiers, knockdown of the H3K4me3 enzymes has been shown to both increase and decrease lifespan, depending on the specific enzyme or context.”
From The Aging Epigenome (2016) · cites this paper as Greer et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,077 · see citing works
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
Java Treeview—extensible visualization of microarray data
Saldanha, A. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth349 · Cited by 2,991 · see citing works
The Sir2 Family of Protein Deacetylases
Blander, G., & Guarente, L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073651 · Cited by 1,496 · see citing works
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
Sijen, T., Fleenor, J., Simmer, F., Thijssen, K. L., Parrish, S., Timmons, L., Plasterk, R. H. A., & Fire, A. Z. (2001) · Cell · doi:10.1016/s0092-8674(01)00576-1 · Cited by 1,280 · see citing works
GOstat: find statistically overrepresented Gene Ontologies within a group of genes
Beißbarth, T., & Speed, T. P. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth088 · Cited by 1,256 · see citing works
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
Ruthenburg, A. J., Allis, C. D., & Wysocka, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.014 · Cited by 1,147 · see citing works
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works
Wysocka, J., Swigut, T., Milne, T. A., Dou, Y., Zhang, X., Burlingame, A. L., Roeder, R. G., Brivanlou, A. H., & Allis, C. D. (2005) · Cell · doi:10.1016/j.cell.2005.03.036 · Cited by 820 · see citing works
Creation of Low-Copy Integrated Transgenic Lines in Caenorhabditis elegans
Praitis, V., Casey, E., Collar, D. C., & Austin, J. (2001) · Genetics · doi:10.1093/genetics/157.3.1217 · Cited by 817 · see citing works
Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801 · see citing works
Self-citationRegulation of MLL1 H3K4 methyltransferase activity by its core components
Dou, Y., Milne, T. A., Ruthenburg, A. J., Lee, S., Lee, J. W., Verdine, G. L., Allis, C. D., & Roeder, R. G. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1128 · Cited by 764 · see citing works
DAF-16 Target Genes That Control <i>C. elegans</i> Life-Span and Metabolism
Lee, S. S., Kennedy, S., Tolonen, A. C., & Ruvkun, G. (2003) · Science · doi:10.1126/science.1083614 · Cited by 669 · see citing works
Histone H4 lysine 16 acetylation regulates cellular lifespan
Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature · doi:10.1038/nature08085 · Cited by 667 · see citing works
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
Miller, T., Krogan, N. J., Dover, J., Erdjument‐Bromage, H., Tempst, P., Johnston, M., Greenblatt, J., & Shilatifard, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231473398 · Cited by 619 · see citing works
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
Fire, A. Z., Harrison, S. W., & Dixon, D. (1990) · Gene · doi:10.1016/0378-1119(90)90224-f · Cited by 617 · see citing works
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
Christensen, J. F., Agger, K., Cloos, P. A., Pasini, D., Rose, S., Sennels, L., Rappsilber, J., Hansen, K. H., Salcini, A. E., & Helin, K. (2007) · Cell · doi:10.1016/j.cell.2007.02.003 · Cited by 554 · see citing works
Hansen, M., Hsu, A., Dillin, A. G., & Kenyon, C. J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010017 · Cited by 533 · see citing works
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans
Arantes-Oliveira, N., Apfeld, J., Dillin, A. G., & Kenyon, C. J. (2002) · Science · doi:10.1126/science.1065768 · Cited by 530 · see citing works
A systematic RNAi screen for longevity genes in C. elegansPreprint
Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., & Lee, S. S. (2005) · Genes & Development · doi:10.1101/gad.1308205 · Cited by 513 · see citing works
Modulation of p53 Function by SET8-Mediated Methylation at Lysine 382
Shi, X., Kachirskaia, I., Yamaguchi, H., West, L. E., Wen, H., Wang, E. W., Dutta, S. M., Appella, E., & Gozani, O. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.012 · Cited by 463 · see citing works
Self-citationKelly, W. G., Xu, S., Montgomery, M. K., & Fire, A. Z. (1997) · Genetics · doi:10.1093/genetics/146.1.227 · Cited by 463 · see citing works
Cheeseman, I. M., Niessen, S., Anderson, S., Barron, F. E., Yates, J. R., Oegema, K., & Desai, A. B. (2004) · Genes & Development · doi:10.1101/gad.1234104 · Cited by 413 · see citing works
Gerisch, B., Weitzel, C., Kober-Eisermann, C., Rottiers, V., & Antebi, A. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00085-5 · Cited by 397 · see citing works
Wysocka, J., Myers, M. P., Laherty, C. D., Eisenman, R. N., & Herr, W. (2003) · Genes & Development · doi:10.1101/gad.252103 · Cited by 390 · see citing works
Berman, J. R., & Kenyon, C. J. (2006) · Cell · doi:10.1016/j.cell.2006.01.039 · Cited by 348 · see citing works
The PIE-1 protein and germline specification in C. elegans embryos
Mello, C. C., Schubert, C., Draper, B. W., et al. (1996) · Nature · doi:10.1038/382710a0 · Cited by 346 · see citing works
Venteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008) · Cell · doi:10.1016/j.cell.2008.01.019 · Cited by 329 · see citing works
Molecular Regulation of Histone H3 Trimethylation by COMPASS and the Regulation of Gene Expression
Schneider, J., Wood, A., Lee, J., Schuster, R. M., Dueker, J., Maguire, C., Swanson, S. K., Florens, L. A., Washburn, M. P., & Shilatifard, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.024 · Cited by 302 · see citing works
Papoulas, O., Beek, S. J., Moseley, S. L., McCallum, C. M., Sarte, M., Shearn, A., & Tamkun, J. W. (1998) · Development · doi:10.1242/dev.125.20.3955 · Cited by 286 · see citing works
Synchronous Growth and Aging of Caenorhabditis elegans in the Presence of Fluorodeoxyuridine
Mitchell, D. H., Stiles, J. W., Santelli, J. S., & Sanadi, D. R. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.1.28 · Cited by 274 · see citing works
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
Budovskaya, Y. V., Wu, K., Southworth, L. K., Jiang, M., Tedesco, P., Johnson, T. E., & Kim, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.05.044 · Cited by 253 · see citing works
Developmental roles of the histone lysine demethylases
Nottke, A. C., Colaiácovo, M. P., & Shi, Y. (2009) · Development · doi:10.1242/dev.020966 · Cited by 225 · see citing works
Siebold, A. P., Banerjee, R., Tie, F., Kiss, D. L., Moskowitz, J., & Harte, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907739107 · Cited by 216 · see citing works
Wnt Signaling Positions Neuromuscular Connectivity by Inhibiting Synapse Formation in C. elegans
Klassen, M. P., & Shen, K. (2007) · Cell · doi:10.1016/j.cell.2007.06.046 · Cited by 212 · see citing works
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705028200 · Cited by 202 · see citing works
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
Li, J., Ebata, A., Dong, Y., Rizki, G., Iwata, T., & Lee, S. S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060233 · Cited by 115 · see citing works
Rapid Coevolution of the Nematode Sex-Determining Genes fem-3 and tra-2
Haag, E. S., Wang, S., & Kimble, J. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01333-7 · Cited by 99 · see citing works
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development
Simonet, T., Dulermo, R., Schott, S., & Palladino, F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.035 · Cited by 69 · see citing works
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span
Chen, S., Whetstine, J. R., Ghosh, S. K., Hanover, J. A., Gali, R. R., Grosu, P., & Shi, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802674106 · Cited by 65 · see citing works
Xu, L., & Strome, S. (2001) · Genetics · doi:10.1093/genetics/159.3.1019 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Histone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241 · see citing works
Self-citationShilatifard, A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-134100 · Cited by 1,091 · see citing works
Epigenetic mechanisms of longevity and aging
Sen, P., Shah, P. P., Nativio, R., & Berger, S. L. (2016) · Cell · doi:10.1016/j.cell.2016.07.050 · Cited by 956 · see citing works
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777 · see citing works
Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686 · see citing works
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660 · see citing works
Self-citationLoss of epigenetic information as a cause of mammalian aging
Yang, J.-H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.027 · Cited by 643 · see citing works
The ageing haematopoietic stem cell compartment
Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604 · see citing works
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works
Self-citationShah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works
Lysosome-mediated processing of chromatin in senescence
Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539 · see citing works
A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551 · see citing works
Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520 · see citing works
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536 · see citing works
Self-citationMolecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works
Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works
Self-citationTwo conserved histone demethylases regulate mitochondrial stress-induced longevity
Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.012 · Cited by 363 · see citing works
Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347 · see citing works
Epigenetic changes during aging and their reprogramming potential
Kane, A. E., & Sinclair, D. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1570075 · Cited by 283 · see citing works
Jin, C., Li, J., Green, C. D., Yu, X., Tang, X., Han, D., Xian, B., Wang, D., Huang, X., Cao, X., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.001 · Cited by 258 · see citing works
Maures, T. J., Greer, E. L., Hauswirth, A. G., & Brunet, A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00738.x · Cited by 256 · see citing works
Self-citationH3K36 methylation promotes longevity by enhancing transcriptional fidelity
Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development · doi:10.1101/gad.263707.115 · Cited by 233 · see citing works
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
Riedel, C. G., Dowen, R. H., Lourenco, G. F., Kirienko, N. V., Heimbucher, T., West, J. A., Bowman, S. K., Kingston, R. E., Dillin, A., Asara, J. M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2720 · Cited by 207 · see citing works
Histone methylation makes its mark on longevity
Han, S., & Brunet, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.001 · Cited by 204 · see citing works
Self-citationAging and reprogramming: a two-way street
Mahmoudi, S., & Brunet, A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.004 · Cited by 171 · see citing works
Self-citationSignaling networks determining life span
Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works
Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds
Rissman, E. F., & Adli, M. (2014) · Endocrinology · doi:10.1210/en.2014-1123 · Cited by 113 · see citing works
Cao, Q., Wang, W., Williams, J. B., Yang, F., Wang, Z.-J., & Yan, Z. (2020) · Science Advances · doi:10.1126/sciadv.abc8096 · Cited by 108 · see citing works
Histone methylation and aging: Lessons learned from model systems
McCauley, B. S., & Dang, W. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.008 · Cited by 93 · see citing works
Zhang, Y., Amaral, M. L., Zhu, C., Grieco, S. F., Hou, X., Lin, L., Buchanan, J., Tong, L., Preissl, S., Xu, X., et al. (2022) · Cell Research · doi:10.1038/s41422-022-00719-6 · Cited by 89 · see citing works
Hot topics in epigenetic mechanisms of aging: 2011
Berdasco, M., & Esteller, M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00806.x · Cited by 86 · see citing works
Aging conundrum: A perspective for ovarian aging
Wu, J., Liu, Y., Song, Y., Wang, L., Ai, J., & Li, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.952471 · Cited by 73 · see citing works
Jiang, N., Du, G., Tobias, E., Wood, J. G., Whitaker, R., Neretti, N., & Helfand, S. L. (2013) · Aging · doi:10.18632/aging.100614 · Cited by 54 · see citing works
- Authors
- Greer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A.
- Affiliations
- Stanford University (US)
- Corresponding author
- Brunet, Anne
- Venue
- Nature
- Published
- 2010-06-16
- Volume
- 466
- Issue
- 7304
- Pages
- 383-387
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3075006
- OpenAlex
- W2078003979
- Cited by
- 543
- References
- 42
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 18 · 2023: 38 · 2022: 34 · 2021: 57 · 2020: 36 · 2019: 41 · 2018: 38 · 2017: 29 · 2016: 37 · 2015: 38 · 2014: 33 · 2013: 39 · 2012: 27
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Maryland Shared Open Access Repository (USMAI Consortium) (submittedVersion)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- National Institutes of Health (5f31ag032837-03)
- National Institute on Aging (R56AG031198, F31-AG032837, R01-AG31198, AG31198, R01AG031198)
- National Human Genome Research Institute (T32HG000044)
- National Cancer Institute (T32CA009302)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- H3K4 trimethylation, H3K4 demethylase, lifespan extension, longevity, germline, oogenesis, histone methylation, chromatin, Caenorhabditis elegans, RNAi screen
- MeSH terms
- Animals, Gene Expression Regulation, Germ Cells, Histones, Longevity, Lysine, Male, Methylation, Nuclear Proteins, Histone-Lysine N-Methyltransferase, Disorders of Sex Development, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Animals, Genetically Modified, RNA Interference, Epigenesis, Genetic, Multiprotein Complexes, Gene Knockdown Techniques, Histone Demethylases, Retinoblastoma-Binding Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
