Conklin, Bruce R.

Integration of biological networks and gene expression data using Cytoscape

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Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

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WikiPathways: Pathway Editing for the People

Pico, A. R., Kelder, T., van Iersel, M. P., Hanspers, K., Conklin, B. R., & Evelo, C. (2008) · PLoS Biology

Bioinformatics and Genomic NetworksWikis in Education and Collaboration

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Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

Federman, A. D., Conklin, B. R., Schrader, K. A., Reed, R. R., & Bourne, H. R. (1992) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

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CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

Mandegar, M. A., Huebsch, N., Frolov, E. B., Shin, E., Truong, A., Olvera, M. P., Chan, A. H., Miyaoka, Y., Holmes, K., Spencer, C. I., et al. (2016) · Cell Stem Cell

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

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Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Wienert, B., Wyman, S. K., Richardson, C. D., Yeh, C. D., Akcakaya, P., Porritt, M. J., Morlock, M., Vu, J. T., Kazane, K. R., Watry, H. L., et al. (2019) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

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A reference human induced pluripotent stem cell line for large-scale collaborative studies

Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., Oguro, H., Kanaujiya, J., Zou, J., Sebesta, D., et al. (2022) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

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Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

Orr, A. G., Hsiao, E. C., Wang, M. M., Ho, K., Kim, D. H., Wang, X., Guo, W., Kang, J., Yu, G.-Q., Adame, A., et al. (2015) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

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Time- and exercise-dependent gene regulation in human skeletal muscle

Zambon, A. C., McDearmon, E. L., Salomonis, N., Vranizan, K. M., Johansen, K. L., Adey, D., Takahashi, J. S., Schambelan, M., & Conklin, B. R. (2003) · Genome Biology

Circadian rhythm and melatoninMuscle Physiology and Disorders

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Self-organizing human cardiac microchambers mediated by geometric confinement

Ma, Z., Wang, J., Loskill, P., Huebsch, N., Koo, S., Svedlund, F. L., Marks, N. C., Hua, E. W., Grigoropoulos, C. P., Conklin, B. R., et al. (2015) · Nature Communications

Pluripotent Stem Cells ResearchCellular Mechanics and Interactions

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Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells

Hoang, P., Wang, J., Conklin, B. R., Healy, K. E., & Ma, Z. (2018) · Nature Protocols

Pluripotent Stem Cells ResearchCongenital heart defects research

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Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression

McCloskey, D. T., Turnbull, L., Swigart, P. M., Zambon, A. C., Turcato, S., Joho, S., Grossman, W., Conklin, B. R., Simpson, P. C., & Baker, A. J. (2005) · Physiological Genomics

Animal Genetics and ReproductionCardiomyopathy and Myosin Studies

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Functional analysis of a common BAG3 allele associated with protection from heart failure

Perez-Bermejo, J. A., Judge, L. M., Jensen, C. L., Wu, K., Watry, H. L., Truong, A., Ho, J. J., Carter, M., Runyon, W. V., Kaake, R. M., et al. (2023) · Nature Cardiovascular Research

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