Biernat, Jacek

Characterization of Alzheimer’s-like Paired Helical Filaments from the Core Domain of Tau Protein Using Solid-State NMR Spectroscopy

Andronesi, O. C., Bergen, M. V., Biernat, J., Seidel, K., Griesinger, C., Mandelkow, E., & Baldus, M. (2008) · Journal of the American Chemical Society

Alzheimer's disease research and treatmentsAdvanced NMR Techniques and Applications

Cited by 167

Folding of the Tau Protein on Microtubules

Kadavath, H., Jaremko, M., Jaremko, Ł., Biernat, J., Mandelkow, E., & Zweckstetter, M. (2015) · Angewandte Chemie International Edition

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 153

The Development of Cell Processes Induced by tau Protein Requires Phosphorylation of Serine 262 and 356 in the Repeat Domain and Is Inhibited by Phosphorylation in the Proline-rich Domains

Biernat, J., & Mandelkow, E.-M. (1999) · Molecular Biology of the Cell

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 149

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

Fischer, D., Mukrasch, M. D., Biernat, J., Bibow, S., Blackledge, M., Griesinger, C., Mandelkow, E., & Zweckstetter, M. (2009) · Biochemistry

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 149

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

Cabrales Fontela, Y., Kadavath, H., Biernat, J., Riedel, D., Mandelkow, E., & Zweckstetter, M. (2017) · Nature Communications

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 148

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila

Steinhilb, M. L., Dias‐Santagata, D., Mulkearns, E. E., Shulman, J. M., Biernat, J., Mandelkow, E., & Feany, M. B. (2007) · Journal of Neuroscience Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 107

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Oroz, J., Chang, B. J., Wysoczanski, P., Lee, C.-T., Pérez-Lara, Á., Chakraborty, P., Hofele, R. V., Baker, J. D., Blair, L. J., Biernat, J., et al. (2018) · Nature Communications

Heat shock proteins researchAlzheimer's disease research and treatments

Cited by 100

Glycogen Synthase Kinase (GSK) 3β Directly Phosphorylates Serine 212 in the Regulatory Loop and Inhibits Microtubule Affinity-regulating Kinase (MARK) 2

Timm, T., Balusamy, K., Li, X., Biernat, J., Mandelkow, E., & Mandelkow, E.-M. (2008) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 95

Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid‐β Peptides

Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E., & Mandelkow, E. (2006) · Traffic

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 82

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

Schwalbe, M., Biernat, J., Bibow, S., Ozenne, V., Jensen, M. R., Kadavath, H., Blackledge, M., Mandelkow, E., & Zweckstetter, M. (2013) · Biochemistry

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 78