Francis, Paul T.

The cholinergic hypothesis of Alzheimer’s disease: A review of progress

Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 2,198

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

Thambisetty, M., Simmons, A., Velayudhan, L., Hye, A., Campbell, J., Zhang, Y., Wahlund, L.-O., Westman, E., Kinsey, A., Güntert, A., et al. (2010) · Archives of General Psychiatry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 405

Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., Evans, J., Lee, M., Porsteinsson, A., Lanctôt, K. L., et al. (2013) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 378

The interplay of neurotransmitters in Alzheimer's disease

Francis, P. T. (2005) · CNS Spectrums

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 302

Cholinergic–serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease

Garcia-Alloza, M., Gil-Bea, F. J., Diez-Ariza, M., Chen, C. P. L.-H., Francis, P. T., Lasheras, B., & Ramirez, M. J. (2005) · Neuropsychologia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 244

Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach

Bereczki, E., Branca, R. M., Francis, P. T., Pereira, J. B., Baek, J.-H., Hortobágyi, T., Winblad, B., Ballard, C., Lehtiö, J., & Aarsland, D. (2018) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 220

Cholinergic deficits contribute to behavioral disturbance in patients with dementia

Minger, S. L., Esiri, M. M., McDonald, B., Keene, J., Carter, J., Hope, T., & Francis, P. T. (2000) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 176

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

Bereczki, E., Francis, P. T., Howlett, D., Pereira, J. B., Höglund, K., Bogstedt, A., Cedazo‐Minguez, A., Baek, J., Hortobágyi, T., Attems, J., et al. (2016) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 167

Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.

Bowen, D. M., Najlerahim, A., Procter, A. W., Francis, P. T., & Murphy, E. (1989) · Proceedings of the National Academy of Sciences

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 157

A Double-Blind Placebo-Controlled Randomized Trial of Melissa officinalis Oil and Donepezil for the Treatment of Agitation in Alzheimer’s Disease

Burns, A., Perry, E., Holmes, C., Francis, P., Morris, J., Howes, M.-J. R., Chazot, P., Lees, G., & Ballard, C. (2011) · Dementia and Geriatric Cognitive Disorders

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 149

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

Alić, I., Goh, P. A., Murray, A., Portelius, E., Gkanatsiou, E., Gough, G., Mok, K. Y., Koschut, D., Brunmeir, R., Yeap, Y. J., et al. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 123

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration

Chai, Y. L., Chong, J. R., Weng, J., Howlett, D., Halsey, A., Lee, J. H., Attems, J., Aarsland, D., Francis, P. T., Chen, C. P., et al. (2019) · Brain Pathology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 73

Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation

Rajkumar, A. P., Bidkhori, G., Shoaie, S., Clarke, E., Morrin, H., Hye, A., Williams, G., Ballard, C., Francis, P., & Aarsland, D. (2020) · The American Journal of Geriatric Psychiatry

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 65

The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells

Webster, M.-T., Pearce, B. R., Bowen, D. M., & Francis, P. T. (1998) · Journal of Neural Transmission

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 62

Clusterin Associates Specifically with A β40 in Alzheimer's Disease Brain Tissue

Howlett, D. R., Hortobágyi, T., & Francis, P. T. (2013) · Brain Pathology

Alzheimer's disease research and treatmentsClusterin in disease pathology

Cited by 51

Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia

Guadagna, S., Esiri, M. M., Williams, R. J., & Francis, P. T. (2012) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 48

Selective effects of the APOE ε4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease

Lai, M. K. P., Tsang, S. W. Y., Garcia-Alloza, M., Minger, S. L., Nicoll, J. A. R., Esiri, M. M., Wong, P. T.-H., Chen, C. P. L.-H., Ramírez, M. J., & Francis, P. T. (2006) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 29

An isoform‐specific role of FynT tyrosine kinase in Alzheimer's disease

Lee, C., Low, C. Y. B., Francis, P. T., Attems, J., Wong, P. T. ‐., Lai, M. K. P., & Tan, M. G. K. (2016) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 27