Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future
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Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS‐PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome‐specific synthetic reviews and recommendations prepared by NPS‐PIA workgroups on depression, apathy, sleep, agitation, and psychosis.
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Mild depressive symptoms in later life might be a prodrome of neurodegenerative diseases, where synaptic density decrease is increasingly described.
“Mild depressive symptoms in later life might be a prodrome of neurodegenerative diseases [52], where synaptic density decrease is increasingly described [53].”
From Preliminary evidence for preserved synaptic density in late-life depression (2024) · cites this paper as [52]
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Ismail, Z., for the NPS Professional Interest Area of the International Society of to Advance Alzheimer’s Research and Treatment (NPS-PIA of ISTAART), Agüera-Ortiz, L., Brodaty, H., Cieslak, A., Cummings, J., Fischer, C. E., Gauthier, S., Geda, Y. E., Herrmann, N., et al. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-160979 · Cited by 530 · see citing works
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- Authors
- Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., Evans, J., Lee, M., Porsteinsson, A., Lanctôt, K. L., Rosenberg, P. B., Sultzer, D. L., Francis, P. T., Brodaty, H., Padala, P. P., Onyike, C. U., Ortiz, L. A., Ancoli‐Israel, S., Bliwise, D. L., Martin, J. L., Vitiello, M. V., Yaffe, K., Zee, P. C., Herrmann, N., Sweet, R. A., Ballard, C., Khin, N. A., Alfaro, C., Murray, P. S., Schultz, S., Lyketsos, C. G., & ISTAART, N. S. P. I. A. O.
- Affiliations
- Mayo Clinic (US)
- University of Southern California (US)
- Johns Hopkins University (US)
- Bracket Wayne PA USA
- Pfizer (United States) (US)
- National Institute of Mental Health (US)
- University of Minnesota (US)
- University of Rochester Medicine (US)
- University of Toronto (CA)
- University of California, Los Angeles (US)
- King's College London (GB)
- UNSW Sydney (AU)
- Geriatric Research Education and Clinical Center Central Arkansas Veterans Healthcare System Little Rock AR USA
- Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM Madrid Spain
- University of California San Diego (US)
- Emory University (US)
- University of Washington (US)
- University of California, San Francisco (US)
- Northwestern University (US)
- Sunnybrook Research Institute (CA)
- University of Pittsburgh (US)
- Alzheimer's Society (GB)
- United States Food and Drug Administration (US)
- University of Iowa (US)
- Corresponding author
- Lyketsos, Constantine G.
- ORCID
- Geda, Yonas E.
- Schneider, Lon S.
- Gitlin, Laura N.
- Smith, Gwenn S.
- Bell, Joanne
- Lee, Michael
- Porsteinsson, Anton
- Lanctôt, Krista L.
- Rosenberg, Paul B.
- Sultzer, David L.
- Francis, Paul T.
- Brodaty, Henry
- Onyike, Chiadikaobi U.
- Ancoli‐Israel, Sonia
- Bliwise, Donald L.
- Martin, Jennifer L.
- Vitiello, Michael V.
- Yaffe, Kristine
- Zee, Phyllis C.
- Herrmann, Nathan
- Sweet, Robert A.
- Ballard, Clive
- Khin, Ni A.
- Murray, Patrick S.
- Schultz, Susan
- Lyketsos, Constantine G.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2013-04-05
- Volume
- 9
- Issue
- 5
- Pages
- 602-608
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC3766403
- OpenAlex
- W1999233676
- Cited by
- 378
- References
- 82
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 29 · 2023: 32 · 2022: 23 · 2021: 40 · 2020: 42 · 2019: 36 · 2018: 23 · 2017: 29 · 2016: 27 · 2015: 38 · 2014: 20 · 2013: 4 · 2012: 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute of Mental Health (K01-MH68351, R24-MH074779, RC1-MH090770-01)
- National Institute on Aging (U01-AG006786)
- National Center for Research Resources (RR024150)
- Robert Wood Johnson Foundation
- Baxter International
- Johnson and Johnson
- Novartis
- Pfizer
- Alzheimer's Association (IIRG-07-28686)
- GlaxoSmithKline
- Eisai
- AstraZeneca
- Eli Lilly and Company
- NFL Foundation
- Elan
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- neuropsychiatric symptoms, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Mental Disorders, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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