Piwnica-Worms, David

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature

Extracellular vesicles in diseaseCancer Genomics and Diagnostics

Cited by 2,880

Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression

Pazolli, E., Alspach, E., Milczarek, A., Prior, J., Piwnica-Worms, D., & Stewart, S. A. (2012) · Cancer Research

Telomeres, Telomerase, and SenescenceHistone Deacetylase Inhibitors Research

Cited by 192

p38MAPK plays a crucial role in stromal-mediated tumorigenesis

Alspach, E., Flanagan, K. C., Luo, X., Ruhland, M. K., Huang, H., Pazolli, E., Donlin, M. J., Marsh, T., Piwnica-Worms, D., Monahan, J., et al. (2014) · Cancer Discovery

Telomeres, Telomerase, and SenescenceTGF-β signaling in diseases

Cited by 167

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

Liu, Z., Turkoz, A., Jackson, E. N., Corbo, J. C., Engelbach, J. A., Garbow, J. R., Piwnica-Worms, D. R., & Kopan, R. (2011) · Journal of Clinical Investigation

Developmental Biology and Gene RegulationAngiogenesis and VEGF in Cancer

Cited by 119

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Kerk, S. A., Lin, L., Myers, A. L., Sutton, D. J., Andren, A., Sajjakulnukit, P., Zhang, L., Zhang, Y., Jiménez, J. A., Nelson, B. S., et al. (2022) · eLife

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 108

A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor

Elhammali, A., Ippolito, J. E., Collins, L., Crowley, J., Marasa, J., & Piwnica-Worms, D. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 77

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Wang, Y. V., Leblanc, M., Fox, N., Mao, J.-H., Tinkum, K. L., Krummel, K., Engle, D., Piwnica-Worms, D., Piwnica-Worms, H., Balmain, A., et al. (2011) · Genes & Development

Hematopoietic Stem Cell TransplantationCancer-related Molecular Pathways

Cited by 53

Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation

Yang, C., Davis, J. L., Zeng, R., Vora, P., Su, X., Collins, L. I., Vangveravong, S., Mach, R. H., Piwnica-Worms, D., Weilbaecher, K. N., et al. (2013) · Cancer Discovery

Bone Metabolism and DiseasesBone health and treatments

Cited by 50

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Awad, D., Cao, P. H. A., Pulliam, T. L., Spradlin, M., Subramani, E., Tellman, T. V., Ribeiro, C. F., Muzzioli, R., Jewell, B. E., Pakula, H., et al. (2024) · Cancer Research

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 36

Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression

Liu, T. W., Gammon, S. T., Yang, P., Fuentes, D., & Piwnica-Worms, D. (2021) · Science Signaling

NF-κB Signaling PathwaysNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 27

Multi-Modal Multi-Spectral Intravital Macroscopic Imaging of Signaling Dynamics in Real Time during Tumor–Immune Interactions

Liu, T. W., Gammon, S. T., Fuentes, D., & Piwnica-Worms, D. (2021) · Cells

bioluminescence and chemiluminescence researchOptical Imaging and Spectroscopy Techniques

Cited by 16