Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression
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MPO in host myeloid cells has antitumor effects during the early stages of melanoma growth.
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The same mechanism has also been substantiated attenuating experimental melanoma progression as a result of myeloid cell-derived HOCl.
“The same mechanism has also been substantiated attenuating experimental melanoma progression as a result of myeloid cell-derived HOCl (175).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [175]
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Self-citationNiemann, B. R., Rao, P., Hopen, Q., Landreth, K. M., Basnet, A., Geldenhuys, W. J., Liu, T. W. B., & Boone, B. A. (2025) · Journal of Inflammation · doi:10.1186/s12950-025-00456-8 · Cited by 4 · see citing works
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Self-citationYoshikawa, M., Sato, Y., Sasaki, M., & Aratani, Y. (2024) · Immunobiology · doi:10.1016/j.imbio.2024.152843 · Cited by 1 · see citing works
Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice
Landreth, K. M., Thomas, D. D., Nohoesu, R., Basnet, A., Damron, F. H., Garland‐Kledzik, M., Sen-Kilic, E., & Liu, T. W. B. (2025) · Aging and Cancer · doi:10.1002/aac2.70006 · Cited by 1 · see citing works
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Advances in endogenous hypochlorous acid-mediated regulation of tumor cell fates
Zhao, W. B., Cui, X., Zheng, K., Du, F., Li, Y., Cai, B., Shang, L., Jing, C., & Li, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1822165
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Bansal, S., Gori, M., & Wang, B. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c02835 · Cited by 1 · see citing works
- Authors
- Liu, T. W., Gammon, S. T., Yang, P., Fuentes, D., & Piwnica-Worms, D.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Piwnica-Worms, David
- Venue
- Science Signaling
- Published
- 2021-04-06
- Volume
- 14
- Issue
- 677
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC12506183
- OpenAlex
- W3150739671
- Cited by
- 27
- References
- 74
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 6
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Cancer Institute (P50 CA94056, P30 CA016672, P30 CA125123)
- University of Texas MD Anderson Cancer Center
- UVA Cancer Center
- National Cancer Institute Molecular Imaging Center (P50 CA94056)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- hypochlorous acid, myeloid cells, paracrine signaling, IKK inhibition, NF-κB signaling, melanoma, tumor progression, antitumor immunity, cytotoxic T lymphocytes
- MeSH terms
- Animals, Hypochlorous Acid, Melanoma, NF-kappa B, CD8-Positive T-Lymphocytes, Phosphatidylinositol 3-Kinases, Myeloid Cells, Mice
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