Cited by 27NF-κB Signaling PathwaysNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer

Myeloid cell–derived HOCl is a paracrine effector that trans-inhibits IKK/NF-κB in melanoma cells and limits early tumor progression

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Liu, Tracy W., Gammon, Seth T., Yang, Ping, Fuentes, David, Piwnica-Worms, David·2021·Science Signaling

Abstract

MPO in host myeloid cells has antitumor effects during the early stages of melanoma growth.

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Authors
Liu, T. W., Gammon, S. T., Yang, P., Fuentes, D., & Piwnica-Worms, D.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Piwnica-Worms, David
Venue
Science Signaling
Published
2021-04-06
Volume
14
Issue
677
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W3150739671
Cited by
27
References
74
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 6
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
  • National Cancer Institute (P50 CA94056, P30 CA016672, P30 CA125123)
  • University of Texas MD Anderson Cancer Center
  • UVA Cancer Center
  • National Cancer Institute Molecular Imaging Center (P50 CA94056)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
hypochlorous acid, myeloid cells, paracrine signaling, IKK inhibition, NF-κB signaling, melanoma, tumor progression, antitumor immunity, cytotoxic T lymphocytes
MeSH terms
Animals, Hypochlorous Acid, Melanoma, NF-kappa B, CD8-Positive T-Lymphocytes, Phosphatidylinositol 3-Kinases, Myeloid Cells, Mice

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