Reik, Wolf

Epigenetic Reprogramming in Mammalian Development

Reik, W., Dean, W., & Walter, J. (2001) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 3,078

Stability and flexibility of epigenetic gene regulation in mammalian development

Reik, W. (2007) · Nature

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 1,963

SC3: consensus clustering of single-cell RNA-seq data

Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,500

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

Smallwood, S. A., Lee, H. J., Angermueller, C., Krueger, F., Saadeh, H., Peat, J., Andrews, S. R., Stegle, O., Reik, W., & Kelsey, G. (2014) · Nature Methods

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 1,125

Placental-specific IGF-II is a major modulator of placental and fetal growth

Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature

Genetic Syndromes and ImprintingPregnancy and preeclampsia studies

Cited by 1,054

A single-cell molecular map of mouse gastrulation and early organogenesis

Pijuan-Sala, B., Griffiths, J. A., Guibentif, C., Hiscock, T. W., Jawaid, W., Calero-Nieto, F. J., Mulas, C., Ibarra-Soria, X., Tyser, R. C. V., Ho, D. L. L., et al. (2019) · Nature

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 1,033

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,025

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

Seisenberger, S., Andrews, S., Krueger, F., Arand, J., Walter, J., Santos, F., Popp, C., Thienpont, B., Dean, W., & Reik, W. (2012) · Molecular Cell

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 973

Uncovering the role of 5-hydroxymethylcytosine in the epigenome

Branco, M. R., Ficz, G., & Reik, W. (2012) · Nature Reviews Genetics

Epigenetics and DNA MethylationRNA modifications and cancer

Cited by 766

Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity

Angermueller, C., Clark, S. J., Lee, H. J., Macaulay, I. C., Teng, M. J., Hu, T. X., Krueger, F., Smallwood, S. A., Ponting, C. P., Voet, T., et al. (2016) · Nature Methods

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 717

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse

Lane, N., Dean, W., Erhardt, S., Hajkova, P., Surani, A., Walter, J., & Reik, W. (2003) · genesis

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 667

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Clark, S. J., Argelaguet, R., Kapourani, C.-A., Stubbs, T. M., Lee, H. J., Alda-Catalinas, C., Krueger, F., Sanguinetti, G., Kelsey, G., Marioni, J. C., et al. (2018) · Nature Communications

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 657

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops

Murrell, A., Heeson, S., & Reik, W. (2004) · Nature Genetics

Genetic Syndromes and ImprintingGenomics and Chromatin Dynamics

Cited by 556

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning

Angermueller, C., Lee, H. J., Reik, W., & Stegle, O. (2017) · Genome Biology

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 536

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

Kurukuti, S., Tiwari, V. K., Tavoosidana, G., Pugacheva, E., Murrell, A., Zhao, Z., Lobanenkov, V., Reik, W., & Ohlsson, R. (2006) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsGenetic Syndromes and Imprinting

Cited by 511

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

Eckersley-Maslin, M. A., Alda-Catalinas, C., & Reik, W. (2018) · Nature Reviews Molecular Cell Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 431

Single-cell epigenomics: Recording the past and predicting the future

Kelsey, G., Stegle, O., & Reik, W. (2017) · Science

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 415

Multi-tissue DNA methylation age predictor in mouse

BI Ageing Clock Team, Stubbs, T. M., Bonder, M. J., Stark, A.-K., Krueger, F., von Meyenn, F., Stegle, O., & Reik, W. (2017) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 384

Global reorganization of the nuclear landscape in senescent cells

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K., Thuret, J.-Y., Andrews, S., Fraser, P., & Reik, W. (2015) · Cell Reports

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 348

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems

Constância, M., Angiolini, E., Sandovici, I., Smith, P., Smith, R., Kelsey, G., Dean, W., Ferguson-Smith, A., Sibley, C. P., Reik, W., et al. (2005) · Proceedings of the National Academy of Sciences

Genetic Syndromes and ImprintingBirth, Development, and Health

Cited by 323

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity

Clark, S. J., Lee, H. J., Smallwood, S. A., Kelsey, G., & Reik, W. (2016) · Genome Biology

Single-cell and spatial transcriptomicsEpigenetics and DNA Methylation

Cited by 310

Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq)

Clark, S. J., Smallwood, S. A., Lee, H. J., Krueger, F., Reik, W., & Kelsey, G. (2017) · Nature Protocols

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 270

Resourceful imprinting

Constância, M., Kelsey, G., & Reik, W. (2004) · Nature

Genetic Syndromes and ImprintingBirth, Development, and Health

Cited by 242

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Hernando-Herraez, I., Evano, B., Stubbs, T., Commere, P.-H., Jan Bonder, M., Clark, S., Andrews, S., Tajbakhsh, S., & Reik, W. (2019) · Nature Communications

Epigenetics and DNA MethylationSingle-cell and spatial transcriptomics

Cited by 236