DNA methylation aging clocks: challenges and recommendations

BEDTools: a flexible suite of utilities for comparing genomic features

Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works

GENCODE: The reference human genome annotation for The ENCODE Project

Harrow, J., Frankish, A., Gonzalez, J. M., Tapanari, E., Diekhans, M., Kokocinski, F., Aken, B. L., Barrell, D., Zadissa, A., Searle, S., et al. (2012) · Genome Research · doi:10.1101/gr.135350.111 · Cited by 4,585 · see citing works

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270 · see citing works

An epigenetic biomarker of aging for lifespan and healthspan

Levine, M. E., Lu, A. T., Quach, A., Chen, B. H., Assimes, T. L., Bandinelli, S., Hou, L., Baccarelli, A. A., Stewart, J. D., Li, Y., et al. (2018) · Aging · doi:10.18632/aging.101414 · Cited by 3,675 · see citing works

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095 · see citing works

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011 · see citing works

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Khera, A. V., Chaffin, M., Aragam, K. G., Haas, M. E., Roselli, C., Choi, S. H., Natarajan, P., Lander, E. S., Lubitz, S. A., Ellinor, P. T., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0183-z · Cited by 2,953 · see citing works

The World Report on Ageing and Health

Beard, J., Officer, A. M., & Cassels, A. (2016) · The Gerontologist · doi:10.1093/geront/gnw037 · Cited by 2,899 · see citing works

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683 · see citing works

DNA methylation GrimAge strongly predicts lifespan and healthspan

Lu, A. T., Quach, A., Wilson, J. G., Reiner, A. P., Aviv, A., Raj, K., Hou, L., Baccarelli, A. A., Li, Y., Stewart, J. D., et al. (2019) · Aging · doi:10.18632/aging.101684 · Cited by 2,540 · see citing works

The human cell atlas

Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P., Carninci, P., Clatworthy, M., et al. (2017) · eLife · doi:10.7554/elife.27041 · Cited by 2,232 · see citing works

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Irizarry, R. A., Ladd-Acosta, C., Wen, B., Wu, Z., Montano, C., Onyango, P., Cui, H., Gabo, K., Rongione, M., Webster, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.298 · Cited by 2,177 · see citing works

Function and information content of DNA methylation

Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060 · see citing works

Epigenetics and the environment: emerging patterns and implications

Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929 · see citing works

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti, C., & Vogelstein, B. (2015) · Science · doi:10.1126/science.1260825 · Cited by 1,927 · see citing works

TET-mediated active DNA demethylation: mechanism, function and beyond

Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661 · see citing works

The personal and clinical utility of polygenic risk scores

Torkamani, A., Wineinger, N. E., & Topol, E. J. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0018-x · Cited by 1,605 · see citing works

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works

Induction of tumors in mice by genomic hypomethylation

Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499 · see citing works

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works

The Human Cell Atlas

Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C. O., Birney, E., Bodenmiller, B., & al, E. (2017) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-162597 · Cited by 1,457 · see citing works

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Baar, M. P., Brandt, R. M. C., Putavet, D. A., Klein, J. D. D., Derks, K. W. J., Bourgeois, B. R. M., Stryeck, S., Rijksen, Y., van Willigenburg, H., Feijtel, D. A., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.031 · Cited by 1,454 · see citing works

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works

Charting a dynamic DNA methylation landscape of the human genome

Ziller, M. J., Gu, H., Müller, F., Donaghey, J., Tsai, L. T.-Y., Kohlbacher, O., De Jager, P. L., Rosen, E. D., Bennett, D. A., Bernstein, B. E., et al. (2013) · Nature · doi:10.1038/nature12433 · Cited by 1,357 · see citing works

Regulatory activities of transposable elements: from conflicts to benefits

Chuong, E. B., Elde, N. C., & Feschotte, C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,343 · see citing works

DNA methylation age of blood predicts all-cause mortality in later life

Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0584-6 · Cited by 1,261 · see citing works

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P. K., Kivioja, T., Dave, K., Zhong, F., et al. (2017) · Science · doi:10.1126/science.aaj2239 · Cited by 1,257 · see citing works

Biological Age Predictors

Jylhävä, J., Pedersen, N. L., & Hägg, S. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.046 · Cited by 1,240 · see citing works

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Montoro, D. T., Haber, A. L., Biton, M., Vinarsky, V., Lin, B., Birket, S. E., Yuan, F., Chen, S., Leung, H. M., Villoria, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0393-7 · Cited by 1,206 · see citing works

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

Issa, J.-P. J., Ottaviano, Y. L., Celano, P., Hamilton, S. R., Davidson, N. E., & Baylin, S. B. (1994) · Nature Genetics · doi:10.1038/ng0894-536 · Cited by 1,191 · see citing works

DNA methylation-based measures of biological age: meta-analysis predicting time to death

Chen, B. H., Marioni, R. E., Colicino, E., Peters, M. J., Ward-Caviness, C. K., Tsai, P.-C., Roetker, N. S., Just, A. C., Demerath, E. W., Guan, W., et al. (2016) · Aging · doi:10.18632/aging.101020 · Cited by 1,126 · see citing works

Somatic mutant clones colonize the human esophagus with age

Martincorena, I., Fowler, J. C., Wabik, A., Lawson, A. R. J., Abascal, F., Hall, M. W. J., Cagan, A., Murai, K., Mahbubani, K., Stratton, M. R., et al. (2018) · Science · doi:10.1126/science.aau3879 · Cited by 1,113 · see citing works

Epigenetic mechanisms of gene regulation

Russo, V. E. A., Martienssen, R. A., & Riggs, A. D. (1996) · Medical Entomology and Zoology · Cited by 1,088 · see citing works

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065 · see citing works

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

Christensen, B. C., Houseman, E. A., Marsit, C. J., Zheng, S., Wrensch, M., Wiemels, J. L., Nelson, H. H., Karagas, M. R., Padbury, J. F., Bueno, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000602 · Cited by 1,062 · see citing works

Epigenetic Predictor of Age

Bocklandt, S., Lin, W., Sehl, M. E., Sánchez, F. J., Sinsheimer, J. S., Horvath, S., & Vilain, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014821 · Cited by 1,012 · see citing works

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951 · see citing works

Joint profiling of chromatin accessibility and gene expression in thousands of single cells

Cao, J., Cusanovich, D. A., Ramani, V., Aghamirzaie, D., Pliner, H. A., Hill, A. J., Daza, R. M., McFaline-Figueroa, J. L., Packer, J. S., Christiansen, L., et al. (2018) · Science · doi:10.1126/science.aau0730 · Cited by 938 · see citing works

DNA methylation and healthy human aging

Jones, M. J., Goodman, S. J., & Kobor, M. S. (2015) · Aging Cell · doi:10.1111/acel.12349 · Cited by 937 · see citing works

Epigenetic Signatures of Cigarette Smoking

Joehanes, R., Just, A. C., Marioni, R. E., Pilling, L. C., Reynolds, L. M., Mandaviya, P. R., Guan, W., Xu, T., Elks, C. E., Aslibekyan, S. W., et al. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.116.001506 · Cited by 915 · see citing works

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

Chen, Y.-A., Lemire, M., Choufani, S., Butcher, D., Grafodatskaya, D., Zanke, B., Gallinger, S., Hudson, T. J., & Weksberg, R. (2013) · Epigenetics · doi:10.4161/epi.23470 · Cited by 908 · see citing works

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

Zheng, J., Erzurumluoglu, A. M., Elsworth, B. L., Kemp, J. P., Howe, L., Haycock, P. C., Hemani, G., Tansey, K., Laurin, C., Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw613 · Cited by 869 · see citing works

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855 · see citing works

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

Weidner, C. I., Lin, Q., Koch, C., Eisele, L., Beier, F., Ziegler, P., Bauerschlag, D., Jöckel, K., Erbel, R., Mühleisen, T., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r24 · Cited by 849 · see citing works

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Horvath, S., Oshima, J., Martin, G. M., Lu, A. T., Quach, A., Cohen, H., Felton, S., Matsuyama, M., Lowe, D., Kabacik, S., et al. (2018) · Aging · doi:10.18632/aging.101508 · Cited by 815 · see citing works

Distinct DNA methylomes of newborns and centenarians

Heyn, H., Li, N., Ferreira, H. J., Moran, S., Pisano, D. G., Gomez, A., Diez, J., Sanchez-Mut, J. V., Setien, F., Carmona, F. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120658109 · Cited by 802 · see citing works

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., et al. (2017) · Aging · doi:10.18632/aging.101168 · Cited by 801 · see citing works

REST and stress resistance in ageing and Alzheimer’s disease

Lu, T., Aron, L., Zullo, J., Pan, Y., Kim, H., Chen, Y., Yang, T.-H., Kim, H., Drake, D., Liu, X., et al. (2014) · Nature · doi:10.1038/nature13163 · Cited by 760 · see citing works

Obesity accelerates epigenetic aging of human liver

Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., Schönfels, W. V., Ahrens, M., Heits, N., Bell, J. T., Tsai, P.-C., Spector, T. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412759111 · Cited by 760 · see citing works

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domainsPreprint

Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 750 · see citing works

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Horvath, S., Gurven, M., Levine, M. E., Trumble, B. C., Kaplan, H. S., Allayee, H., Ritz, B. R., Chen, B. H., Lu, A. T.-H., Rickabaugh, T. M., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1030-0 · Cited by 729 · see citing works

The transcriptional landscape of age in human peripheral blood

Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., Reinmaa, E., Sutphin, G. L., Zhernakova, A., Schramm, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms9570 · Cited by 725 · see citing works

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

Baubec, T., Colombo, D. F., Wirbelauer, C., Schmidt, J., Burger, L., Krebs, A. R., Akalin, A., & Schübeler, D. (2015) · Nature · doi:10.1038/nature14176 · Cited by 705 · see citing works

Human body epigenome maps reveal noncanonical DNA methylation variation

Schultz, M. D., He, Y., Whitaker, J. W., Hariharan, M., Mukamel, E. A., Leung, D., Rajagopal, N., Nery, J. R., Urich, M. A., Chen, H., et al. (2015) · Nature · doi:10.1038/nature14465 · Cited by 690 · see citing works

Epigenetics and aging: the targets and the marks

Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · see citing works

The UCSC Genome Browser database: 2014 update

Karolchik, D., Barber, G. P., Casper, J., Clawson, H., Cline, M. S., Diekhans, M., Dreszer, T. R., Fujita, P. A., Guruvadoo, L., Haeussler, M., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1168 · Cited by 670 · see citing works

Dynamic DNA methylation: In the right place at the right time

Luo, C., Hajkova, P., & Ecker, J. R. (2018) · Science · doi:10.1126/science.aat6806 · Cited by 668 · see citing works

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Clark, S. J., Argelaguet, R., Kapourani, C.-A., Stubbs, T. M., Lee, H. J., Alda-Catalinas, C., Krueger, F., Sanguinetti, G., Kelsey, G., Marioni, J. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03149-4 · Cited by 657 · see citing works

DNA Methylation Decreases in Aging But Not in Immortal Cells

Wilson, V. L., & Jones, P. A. (1983) · Science · doi:10.1126/science.6844925 · Cited by 649 · see citing works

Aging and neurodegeneration are associated with increased mutations in single human neurons

Lodato, M. A., Rodin, R. E., Bohrson, C. L., Coulter, M. E., Barton, A. R., Kwon, M., Sherman, M. A., Vitzthum, C. M., Luquette, L. J., Yandava, C. N., et al. (2018) · Science · doi:10.1126/science.aao4426 · Cited by 635 · see citing works

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625 · see citing works

DNA Methylation Clocks in Aging: Categories, Causes, and Consequences

Field, A. E., Robertson, N., Wang, T., Havas, A. P., Ideker, T., & Adams, P. D. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.008 · Cited by 622 · see citing works

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works

Increased cell-to-cell variation in gene expression in ageing mouse heart

Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature · doi:10.1038/nature04844 · Cited by 603 · see citing works

Systematic identification of genetic influences on methylation across the human life course

Gaunt, T. R., Shihab, H. A., Hemani, G., Min, J. L., Woodward, G., Lyttleton, O., Zheng, J., Duggirala, A., McArdle, W. L., Ho, K., et al. (2016) · Genome Biology · doi:10.1186/s13059-016-0926-z · Cited by 598 · see citing works

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

Perna, L., Zhang, Y., Mons, U., Holleczek, B., Saum, K.-U., & Brenner, H. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0228-z · Cited by 572 · see citing works

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

Relton, C. L., & Davey Smith, G. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr233 · Cited by 567 · see citing works

The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936

Marioni, R. E., Shah, S. H., McRae, A. F., Ritchie, S. J., Terrera, G. M., Harris, S. E., Gibson, J., Redmond, P. H., Cox, S. R., Pattie, A., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu277 · Cited by 559 · see citing works

Widespread and tissue specific age-related DNA methylation changes in mice

Maegawa, S., Hinkal, G., Kim, H. S., Shen, L., Zhang, L., Zhang, J., Zhang, N., Liang, S., Donehower, L. A., & Issa, J.-P. J. (2010) · Genome Research · doi:10.1101/gr.096826.109 · Cited by 553 · see citing works

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551 · see citing works

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning

Angermueller, C., Lee, H. J., Reik, W., & Stegle, O. (2017) · Genome Biology · doi:10.1186/s13059-017-1189-z · Cited by 536 · see citing works

Integrative annotation of chromatin elements from ENCODE data

Hoffman, M. M., Ernst, J., Wilder, S. P., Kundaje, A. B., Harris, R. S., Libbrecht, M., Giardine, B. M., Ellenbogen, P. M., Bilmes, J. A., Birney, E., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1284 · Cited by 521 · see citing works

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0381-y · Cited by 513 · see citing works

Competition between DNA methylation and transcription factors determines binding of NRF1

Domcke, S., Bardet, A. F., Adrian Ginno, P., Hartl, D., Burger, L., & Schübeler, D. (2015) · Nature · doi:10.1038/nature16462 · Cited by 508 · see citing works

Menopause accelerates biological aging

Levine, M. E., Lu, A. T.-H., Chen, B. H., Hernandez, D. G., Singleton, A., Ferrucci, L., Bandinelli, S., Salfati, E., Manson, J. E., Quach, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604558113 · Cited by 507 · see citing works

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., He, J., Fan, D., Fowdar, J., Kennedy, M., et al. (2019) · Genome Medicine · doi:10.1186/s13073-019-0667-1 · Cited by 487 · see citing works

Regulation of transposable elements by DNA modifications

Deniz, Ö., Frost, J. M., & Branco, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0106-6 · Cited by 480 · see citing works

Disease variants alter transcription factor levels and methylation of their binding sites

Bonder, M. J., Luijk, R., Zhernakova, D. V., Moed, M., Deelen, P., Vermaat, M., van Iterson, M., van Dijk, F., van Galen, M., Bot, J. J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3721 · Cited by 462 · see citing works

Enhancer-promoter interactions are encoded by complex genomic signatures on looping chromatin

Whalen, S., Truty, R. M., & Pollard, K. S. (2016) · Nature Genetics · doi:10.1038/ng.3539 · Cited by 456 · see citing works

Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning

Levine, M. E., Lu, A. T., Bennett, D. A., & Horvath, S. (2015) · Aging · doi:10.18632/aging.100864 · Cited by 455 · see citing works

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

Plass, C., Pfister, S. M., Lindroth, A. M., Bogatyrova, O., Claus, R., & Lichter, P. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3554 · Cited by 448 · see citing works

DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P.-C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., et al. (2019) · Aging · doi:10.18632/aging.102173 · Cited by 440 · see citing works

Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients

Horvath, S., & Ritz, B. R. (2015) · Aging · doi:10.18632/aging.100859 · Cited by 435 · see citing works

Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Belsky, D. W., Moffitt, T. E., Cohen, A. A., Corcoran, D. L., Levine, M. E., Prinz, J. A., Schaefer, J. D., Sugden, K., Williams, B. S., Poulton, R., et al. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx346 · Cited by 419 · see citing works

A DNA methylation fingerprint of 1628 human samplesPreprint

Fernández, A. F., Assenov, Y., Martín-Subero, J. I., Bálint, B., Siebert, R., Taniguchi, H., Yamamoto, H., Hidalgo, M. M., Tan, A. C., Galm, O., et al. (2011) · Genome Research · doi:10.1101/gr.119867.110 · Cited by 415 · see citing works

Single-cell epigenomics: Recording the past and predicting the future

Kelsey, G., Stegle, O., & Reik, W. (2017) · Science · doi:10.1126/science.aan6826 · Cited by 415 · see citing works

DNA methylation pattern changes upon long‐term culture and aging of human mesenchymal stromal cells

Bork, S., Pfister, S. M., Witt, H., Horn, P., Korn, B., Ho, A. D., & Wagner, W. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00535.x · Cited by 411 · see citing works

DNA methylation loss in late-replicating domains is linked to mitotic cell division

Zhou, W., Dinh, H. Q., Ramjan, Z., Weisenberger, D. J., Nicolet, C. M., Shen, H., Laird, P. W., & Berman, B. P. (2018) · Nature Genetics · doi:10.1038/s41588-018-0073-4 · Cited by 405 · cited 4× · see citing works

The continuing value of twin studies in the omics era

van Dongen, J., Slagboom, P., Draisma, H., Martin, N. G., & Boomsma, D. (2012) · Nature reviews genetics · doi:10.1038/nrg3243 · Cited by 398 · see citing works

Using DNA methylation profiling to evaluate biological age and longevity interventions

Petkovich, D. A., Podolskiy, D. I., Lobanov, A. V., Lee, S.-G., Miller, R. A., & Gladyshev, V. N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.016 · Cited by 398 · see citing works

Genetic and environmental influences interact with age and sex in shaping the human methylome

van Dongen, J., Nivard, M. G., Willemsen, G. A. H. M., Hottenga, J., Helmer, Q., Dolan, C. V., Ehli, E. A., Davies, G. E., van Iterson, M., Breeze, C. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms11115 · Cited by 396 · see citing works

Prioritizing diversity in human genomics research

Hindorff, L. A., Bonham, V. L., Brody, L. C., Ginoza, M. E. C., Hutter, C. M., Manolio, T. A., & Green, E. D. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.89 · Cited by 386 · see citing works

Multi-tissue DNA methylation age predictor in mouse

BI Ageing Clock Team, Stubbs, T. M., Bonder, M. J., Stark, A.-K., Krueger, F., von Meyenn, F., Stegle, O., & Reik, W. (2017) · Genome Biology · doi:10.1186/s13059-017-1203-5 · Cited by 384 · see citing works

DNA methylation signatures in peripheral blood strongly predict all-cause mortality

Zhang, Y., Wilson, R., Heiss, J., Breitling, L. P., Saum, K.-U., Schöttker, B., Holleczek, B., Waldenberger, M., Peters, A., & Brenner, H. (2017) · Nature Communications · doi:10.1038/ncomms14617 · Cited by 382 · see citing works

Age-associated DNA methylation in pediatric populationsPreprint

Alisch, R. S., Barwick, B. G., Chopra, P., Myrick, L. K., Satten, G. A., Conneely, K. N., & Warren, S. T. (2012) · Genome Research · doi:10.1101/gr.125187.111 · Cited by 380 · see citing works

Senescent cells harbour features of the cancer epigenome

Cruickshanks, H. A., McBryan, T., Nelson, D. M., VanderKraats, N. D., Shah, P. P., van Tuyn, J., Singh Rai, T., Brock, C., Donahue, G., Dunican, D. S., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2879 · Cited by 358 · see citing works

DNA methylation presents distinct binding sites for human transcription factors

Hu, S., Wan, J., Su, Y., Song, Q., Zeng, Y., Nguyen, H. N., Shin, J., Cox, E., Rho, H. S., Woodard, C., et al. (2013) · eLife · doi:10.7554/elife.00726 · Cited by 349 · see citing works

Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach

Mendelson, M., Marioni, R. E., Joehanes, R., Liu, C., Hedman, Å. K., Aslibekyan, S. W., Demerath, E. W., Guan, W., Zhi, D., Yao, C., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002215 · Cited by 343 · see citing works

Aging increases cell-to-cell transcriptional variability upon immune stimulation

Martinez-Jimenez, C. P., Eling, N., Chen, H.-C., Vallejos, C. A., Kolodziejczyk, A. A., Connor, F., Stojic, L., Rayner, T. F., Stubbington, M. J. T., Teichmann, S. A., et al. (2017) · Science · doi:10.1126/science.aah4115 · Cited by 339 · see citing works

Association of the clinical frailty scale with hospital outcomes

Wallis, S. J., Wall, J., Biram, R., & Romero‐Ortuño, R. (2015) · QJM · doi:10.1093/qjmed/hcv066 · Cited by 335 · see citing works

Correlation of an epigenetic mitotic clock with cancer risk

Yang, Z., Wong, A., Kuh, D., Paul, D. S., Rakyan, V. K., Leslie, R. D., Zheng, S. C., Widschwendter, M., Beck, S., & Teschendorff, A. E. (2016) · Genome Biology · doi:10.1186/s13059-016-1064-3 · Cited by 325 · see citing works

Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

Cheung, P., Vallania, F., Warsinske, H. C., Donato, M., Schaffert, S., Chang, S. E., Dvorak, M., Dekker, C. L., Davis, M. M., Utz, P. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.079 · Cited by 323 · cited 2× · see citing works

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

Teschendorff, A. E., West, J., & Beck, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt375 · Cited by 318 · see citing works

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

Blackledge, N. P., Zhou, J., Tolstorukov, M. Y., Farcas, A. M., Park, P. J., & Klose, R. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.04.009 · Cited by 310 · see citing works

Epigenetic-aging-signature to determine age in different tissues

Koch, C., & Wagner, W. (2011) · Aging · doi:10.18632/aging.100395 · Cited by 309 · see citing works

DNA methylation age is associated with mortality in a longitudinal Danish twin study

Christiansen, L., Lenart, A. G., Tan, Q., Vaupel, J. W., Aviv, A., McGue, M. K., & Christensen, K. (2015) · Aging Cell · doi:10.1111/acel.12421 · Cited by 306 · see citing works

Histone Acetylome-wide Association Study of Autism Spectrum Disorder

Sun, W., Poschmann, J., Cruz-Herrera del Rosario, R., Parikshak, N. N., Hajan, H. S., Kumar, V., Ramasamy, R., Belgard, T. G., Elanggovan, B., Wong, C. C. Y., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.031 · Cited by 306 · see citing works

Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment

Hodges, E., Molaro, A., dos Santos, C. O., Thekkat, P. U., Song, Q., Uren, P. J., Park, J., Butler, J., Rafii, S., McCombie, W., et al. (2011) · Molecules and Cells · doi:10.1016/j.molcel.2011.08.026 · Cited by 304 · see citing works

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

Wang, T., Tsui, B., Kreisberg, J. F., Robertson, N., Gross, A. M., Yu, M., Carter, H. K., Brown‐Borg, H. M., Adams, P. D., & Ideker, T. E. (2017) · Genome biology · doi:10.1186/s13059-017-1186-2 · Cited by 294 · see citing works

Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)

Relton, C. L., Gaunt, T. R., McArdle, W. L., Ho, K. M., Duggirala, A., Shihab, H. A., Woodward, G., Lyttleton, O., Evans, D. M., Reik, W., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv072 · Cited by 287 · see citing works

Associating cellular epigenetic models with human phenotypes

Lappalainen, T., & Greally, J. M. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.32 · Cited by 282 · see citing works

Caloric restriction delays age-related methylation drift

Maegawa, S., Lu, Y., Tahara, T., Lee, J. T., Madžo, J., Liang, S., Jelı́nek, J., Colman, R. J., & Issa, J. J. (2017) · Nature Communications · doi:10.1038/s41467-017-00607-3 · Cited by 278 · see citing works

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

Klein, H., Aubin, C., Gjoneska, E., Sullivan, S. E., Kaskow, B. J., Tang, A. Y., Smith, R. V., Xu, J., Pfenning, A. R., Bernstein, B., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0291-1 · Cited by 267 · see citing works

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

Gladyshev, V. N. (2016) · Aging Cell · doi:10.1111/acel.12480 · Cited by 254 · see citing works

Epigenomics of human CD8 T cell differentiation and aging

Moskowitz, D. M., Zhang, D. W., Hu, B., Le Saux, S., Yanes, R. E., Ye, Z., Buenrostro, J. D., Weyand, C. M., Greenleaf, W. J., & Goronzy, J. J. (2017) · Science Immunology · doi:10.1126/sciimmunol.aag0192 · Cited by 252 · cited 4× · see citing works

Prenatal and early life influences on epigenetic age in children: A study of mother–offspring pairs from two cohort studies

Simpkin, A. J., Hemani, G., Suderman, M., Gaunt, T. R., Lyttleton, O., Mcardle, W. L., Ring, S. M., Sharp, G. C., Tilling, K., Horvath, S., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddv456 · Cited by 246 · see citing works

Epigenetic prediction of complex traits and death

McCartney, D. L., Hillary, R. F., Stevenson, A. J., Ritchie, S. J., Walker, R. M., Zhang, Q., Morris, S. W., Bermingham, M. L., Campbell, A., Murray, A. D., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1514-1 · Cited by 244 · see citing works

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

Hernando-Herraez, I., Evano, B., Stubbs, T., Commere, P.-H., Jan Bonder, M., Clark, S., Andrews, S., Tajbakhsh, S., & Reik, W. (2019) · Nature Communications · doi:10.1038/s41467-019-12293-4 · Cited by 236 · see citing works

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Hahn, O., Grönke, S., Stubbs, T. M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M. J. O., Beyer, A., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1187-1 · Cited by 232 · see citing works

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase

Schutsky, E. K., DeNizio, J. E., Hu, P., Liu, M. Y., Nabel, C. S., Fabyanic, E. B., Hwang, Y., Bushman, F. D., Wu, H., & Kohli, R. M. (2018) · Nature Biotechnology · doi:10.1038/nbt.4204 · Cited by 228 · see citing works

Integrative analysis of haplotype-resolved epigenomes across human tissues

Leung, D., Jung, I., Rajagopal, N., Schmitt, A. D., Selvaraj, S., Lee, A. Y., Yen, C., Lin, S., Lin, Y., Qiu, Y., et al. (2015) · Nature · doi:10.1038/nature14217 · Cited by 225 · see citing works

Blood Epigenetic Age may Predict Cancer Incidence and Mortality

Zheng, Y., Joyce, B. T., Colicino, E., Liu, L., Zhang, W., Dai, Q., Shrubsole, M. J., Kibbe, W. A., Gao, T., Zhang, Z., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.02.008 · Cited by 219 · see citing works

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

Lee, M.-H., Siddoway, B., Kaeser, G. E., Segota, I., Rivera, R., Romanow, W. J., Liu, C. S., Park, C., Kennedy, G., Long, T., et al. (2018) · Nature · doi:10.1038/s41586-018-0718-6 · Cited by 210 · see citing works

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R. C., Relton, C. L., Gaunt, T. R., Slagboom, P. E., & Heijmans, B. T. (2018) · Epigenetics & Chromatin · doi:10.1186/s13072-018-0191-3 · Cited by 207 · see citing works

GWAS of epigenetic aging rates in blood reveals a critical role for TERT

Lu, A. T.-H., Xue, L., Salfati, E., Chen, B. H., Ferrucci, L., Levy, D. A., Joehanes, R., Murabito, J. M., Kiel, D. P., Tsai, P.-C., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02697-5 · Cited by 206 · see citing works

A multi-tissue full lifespan epigenetic clock for mice

Thompson, M. J., Chwiałkowska, K., Rubbi, L., Lusis, A. J., Davis, R. C., Srivastava, A., Korstanje, R., Churchill, G. A., Horvath, S., & Pellegrini, M. (2018) · Aging · doi:10.18632/aging.101590 · Cited by 203 · see citing works

Age-related variations in the methylome associated with gene expression in human monocytes and T cells

Reynolds, L. M., Taylor, J. R., Ding, J., Lohman, K., Johnson, C. W., Siscovick, D. S., Burke, G. L., Post, W. S., Shea, S., Jacobs, D. R., et al. (2014) · Nature Communications · doi:10.1038/ncomms6366 · Cited by 201 · see citing works

ADVANCES IN CLINICAL CHEMISTRY

Neill, D. W. (1961) · Journal of Clinical Pathology · doi:10.1136/jcp.14.4.453-a · Cited by 199 · see citing works

Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins

Hannon, E., Knox, O., Sugden, K., Burrage, J., Wong, C., Belsky, D. W., Corcoran, D., Arseneault, L., Moffitt, T., Caspi, A., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007544 · Cited by 187 · see citing works

Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

Martino, D., Loke, Y. J., Gordon, L., Ollikainen, M., Cruickshank, M. N., Saffery, R., & Craig, J. M. (2013) · Genome biology · doi:10.1186/gb-2013-14-5-r42 · Cited by 186 · see citing works

Epigenetic estimation of age in humpback whales

Polanowski, A. M., Robbins, J., Chandler, D., & Jarman, S. (2014) · Molecular Ecology Resources · doi:10.1111/1755-0998.12247 · Cited by 184 · see citing works

Aging, DNA methylation and cancer

Issa, J. J. (1999) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(99)00019-0 · Cited by 183 · see citing works

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Cole, J. J., Robertson, N., Rather, M. I., Thomson, J. P., McBryan, T., Sproul, D., Wang, T., Brock, C., Clark, W. A., Ideker, T. E., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1185-3 · Cited by 182 · see citing works

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

Olova, N. N., Simpson, D. J., Marioni, R. E., & Chandra, T. (2018) · Aging Cell · doi:10.1111/acel.12877 · Cited by 179 · see citing works

A whole lifespan mouse multi-tissue DNA methylation clock

Meer, M. V., Podolskiy, D. I., Tyshkovskiy, A., & Gladyshev, V. N. (2018) · eLife · doi:10.7554/elife.40675 · Cited by 176 · see citing works

Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals

Nevalainen, T., Kananen, L., Marttila, S., Jylhävä, J., Mononen, N., Kähönen, M. A. P., Raitakari, O. T., Hervonen, A., Jylhä, M. K., Lehtimäki, T. J., et al. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0301-7 · Cited by 173 · see citing works

AHRR(cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality

Bojesen, S. E., Timpson, N. J., Relton, C. L., Smith, G. D., & Nordestgaard, B. G. (2017) · Thorax · doi:10.1136/thoraxjnl-2016-208789 · Cited by 172 · see citing works

Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes

Blattler, A., Yao, L.-J., Witt, H., Guo, Y., Nicolet, C., Berman, B. P., & Farnham, P. (2014) · Genome Biology · doi:10.1186/s13059-014-0469-0 · Cited by 171 · see citing works

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1053-6 · Cited by 169 · see citing works

Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution

Shema, E., Bernstein, B., & Buenrostro, J. D. (2018) · Nature Genetics · doi:10.1038/s41588-018-0290-x · Cited by 164 · see citing works

Genomic patterns and context specific interpretation of DNA methylation

Baubec, T., & Schübeler, D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.11.015 · Cited by 163 · see citing works

The blue zones: Areas of exceptional longevity around the world

Poulain, M., Herm, A., & Pes, G. (2014) · Vienna Yearbook of Population Research · doi:10.1553/populationyearbook2013s87 · Cited by 162 · see citing works

A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects

McClay, J. L., Åberg, K. A., Clark, S. L., Nerella, S., Kumar, G., Xie, L. Y., Hudson, A. D., Harada, A., Hultman, C. M., Magnusson, P. K. E., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt511 · Cited by 162 · see citing works

An epigenetic aging clock for dogs and wolves

Thompson, M. J., vonHoldt, B. M., Horvath, S., & Pellegrini, M. A. (2017) · Aging · doi:10.18632/aging.101211 · Cited by 159 · see citing works

Chapter 5 Biomarkers Related To Aging In Human Populations

Crimmins, E. M., Vasunilashorn, S. M., Kim, J. K., & Alley, D. E. (2008) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)00405-8 · Cited by 156 · see citing works

Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Bell, C. G., Gao, F., Yuan, W., Roos, L., Acton, R., Xia, Y., Bell, J. T., Ward, K. J., Mangino, M., Hysi, P. G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01586-1 · Cited by 156 · see citing works

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

Yuan, T., Jiao, Y., de Jong, S., Ophoff, R. A., Beck, S., & Teschendorff, A. E. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004996 · Cited by 155 · cited 1× · see citing works

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Rimmelé, P., Bigarella, C. L., Liang, R. H.-S., Izac, B., Dieguez‐Gonzalez, R., Barbet, G., Donovan, M. J., Brugnara, C., Blander, J. M., Sinclair, D. A., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.04.015 · Cited by 154 · see citing works

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

Jones, A., Teschendorff, A. E., Li, Q., Hayward, J. D., Kannan, A., Mould, T., West, J., Zikán, M., Cibula, D., Fiegl, H., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001551 · Cited by 150 · see citing works

Accelerated epigenetic aging in Werner syndrome

Maierhofer, A., Flunkert, J., Oshima, J., Martin, G. M., Haaf, T., & Horvath, S. (2017) · Aging · doi:10.18632/aging.101217 · Cited by 150 · see citing works

Epigenetic clock analyses of cellular senescence and ageing.

Lowe, D., Horvath, S., & Raj, K. (2016) · Oncotarget · doi:10.18632/oncotarget.7383 · Cited by 147 · see citing works

Concordant and discordant DNA methylation signatures of aging in human blood and brain

Farré, P., Jones, M. J., Meaney, M. J., Emberly, E. G., Turecki, G., & Kobor, M. S. (2015) · Epigenetics & Chromatin · doi:10.1186/s13072-015-0011-y · Cited by 145 · see citing works

Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

Shah, S. H., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D., Henders, A. K., Mendelson, M., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.014 · Cited by 133 · see citing works

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Khoury, L. Y. E., Gorrie-Stone, T. J., Smart, M., Hughes, A., Bao, Y., Andrayas, A., Burrage, J., Hannon, E. J., Meena Kumari, B., Mill, J. S., et al. (2019) · Genome biology · doi:10.1186/s13059-019-1810-4 · Cited by 133 · see citing works

The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort

Simpkin, A. J., Howe, L. D., Tilling, K. M., Gaunt, T. R., Lyttleton, O., McArdle, W. L., Ring, S. M., Horvath, S., Smith, G. D., & Relton, C. L. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw307 · Cited by 131 · see citing works

Tracking the Epigenetic Clock Across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data

Marioni, R. E., Suderman, M. J., Chen, B. H., Horvath, S., Bandinelli, S., Morris, T. J., Beck, S., Ferrucci, L., Pedersen, N. L., Relton, C. L., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly060 · Cited by 130 · see citing works

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions

Lu, A. T.-H., Hannon, E. J., Levine, M. E., Crimmins, E. M., Lunnon, K., Mill, J. S., Geschwind, D. H., & Horvath, S. (2017) · Nature Communications · doi:10.1038/ncomms15353 · Cited by 125 · see citing works

Pluripotent stem cells escape from senescence-associated DNA methylation changesPreprint

Koch, C., Reck, K., Shao, K., Lin, Q., Joussen, S., Ziegler, P., Walenda, G., Drescher, W., Opalka, B., May, T., et al. (2012) · Genome Research · doi:10.1101/gr.141945.112 · Cited by 121 · see citing works

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Lequarré, A., Andersson, L., André, C., Fredholm, M., Hitte, C., Leeb, T., Lohi, H., Lindblad‐Toh, K., & Georges, M. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.06.013 · Cited by 115 · see citing works

LIFE-COURSE LONGITUDINAL STUDIES ARE NEEDED TO ADVANCE INTEGRATION OF GENOMICS AND SOCIAL EPIDEMIOLOGY

Belsky, D. W. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy060 · Cited by 113 · see citing works

From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence

Vidaki, A., & Kayser, M. (2017) · Genome biology · doi:10.1186/s13059-017-1373-1 · Cited by 108 · see citing works

Back to the future: Epigenetic clock plasticity towards healthy aging

Declerck, K., & Berghe, W. V. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.01.002 · Cited by 105 · see citing works

Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course

Hughes, A., Smart, M., Gorrie-Stone, T. J., Hannon, E. J., Mill, J. S., Bao, Y., Burrage, J., Schalkwyk, L. C., & Meena Kumari, B. (2018) · American Journal of Epidemiology · doi:10.1093/aje/kwy155 · Cited by 104 · see citing works

Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1

Martin-Herranz, D. E., Aref‐Eshghi, E., Bonder, M. J., Stubbs, T. M., Choufani, S., Weksberg, R., Stegle, O., Sadiković, B., Reik, W., & Thornton, J. M. (2019) · Genome biology · doi:10.1186/s13059-019-1753-9 · Cited by 100 · see citing works

Author Correction: Regulation of transposable elements by DNA modifications

Deniz, Ö., Frost, J. M., & Branco, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0117-3 · Cited by 99 · see citing works

Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus

Stefanelli, G., Azam, A. B., Walters, B. J., Brimble, M. A., Gettens, C. P., Bouchard-Cannon, P., Cheng, H.-Y. M., Davidoff, A. M., Narkaj, K., Day, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.020 · Cited by 98 · see citing works

Measuring Animal Age with DNA Methylation: From Humans to Wild Animals

Paoli‐Iseppi, R. D., Deagle, B. E., McMahon, C. R., Hindell, M. A., Dickinson, J. L., & Jarman, S. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00106 · Cited by 95 · see citing works

Exploring the emerging complexity in transcriptional regulation of energy homeostasis

Lempradl, A. M., Pospisilik, J. A., & Penninger, J. M. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3941 · Cited by 94 · see citing works

Forensic DNA methylation profiling from evidence material for investigative leads

Lee, H. Y., Lee, S. D., & Shin, K. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.7.070 · Cited by 90 · see citing works

Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

Lowe, R., Barton, C., Jenkins, C. A., Ernst, C., Forman, O. P., Fernandez‐Twinn, D. S., Bock, C., Rossiter, S. J., Faulkes, C. G., Ozanne, S. E., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1397-1 · Cited by 89 · see citing works

Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Tan, L., Ke, Z., Tombline, G., Macoretta, N., Hayes, K., Tian, X., Lv, R., Ablaeva, J., Gilbert, M., Bhanu, N. V., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.001 · Cited by 88 · see citing works

Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancerPreprint

Estecio, M. R., Gallegos, J. J., Vallot, C., Castoro, R. J., Chung, W., Maegawa, S., Oki, Y., Kondo, Y., Jelı́nek, J., Shen, L., et al. (2010) · Genome Research · doi:10.1101/gr.107318.110 · Cited by 86 · see citing works

A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns

Genereux, D. P., Miner, B. E., Bergstrom, C. T., & Laird, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502036102 · Cited by 85 · see citing works

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum

Lunnon, K., Hannon, E. J., Smith, R. G., Dempster, E. L., Wong, C. C. Y., Burrage, J., Troakes, C., Al‐Sarraj, S., Kepa, A., Schalkwyk, L. C., et al. (2016) · Genome biology · doi:10.1186/s13059-016-0871-x · Cited by 85 · see citing works

Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency

Rulands, S., Lee, H. J., Clark, S. J., Angermueller, C., Smallwood, S. A., Krueger, F., Mohammed, H., Dean, W., Nichols, J., Rugg‐Gunn, P. J., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.06.012 · Cited by 83 · see citing works

Age-related epigenetic drift in the pathogenesis of MDS and AMLPreprint

Maegawa, S., Gough, S. M., Watanabe‐Okochi, N., Lu, Y., Zhang, N., Castoro, R. J., Estecio, M. R., Jelı́nek, J., Liang, S., Kitamura, T., et al. (2014) · Genome Research · doi:10.1101/gr.157529.113 · Cited by 82 · see citing works

The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types

Youn, A., & Wang, S. (2017) · Epigenetics · doi:10.1080/15592294.2017.1389361 · Cited by 82 · see citing works

SINE Retrotransposons Cause Epigenetic Reprogramming of Adjacent Gene Promoters

Estecio, M. R., Gallegos, J. J., Dekmezian, M. S., Lu, Y., Liang, S., & Issa, J. J. (2012) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0351 · Cited by 80 · see citing works

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction

Sziráki, A., Tyshkovskiy, A., & Gladyshev, V. N. (2018) · Aging Cell · doi:10.1111/acel.12738 · Cited by 73 · see citing works

“Looking Old for Your Age”: Genetics and Mortality

Christensen, K., Iachina, M., Rexbye, H., Tomassini, C., Frederiksen, H., McGue, M. K., & Vaupel, J. W. (2004) · Epidemiology · doi:10.1097/01.ede.0000112211.11416.a6 · Cited by 70 · see citing works

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression

Kabacik, S., Horvath, S., Cohen, H., & Raj, K. (2018) · Aging · doi:10.18632/aging.101588 · Cited by 68 · see citing works

Mendelian Randomization: Applications and Limitations in Epigenetic Studies

Relton, C. L., & Smith, G. D. (2015) · Epigenomics · doi:10.2217/epi.15.88 · Cited by 67 · see citing works

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study

Raina, A., Zhao, X., Grove, M. L., Bressler, J., Gottesman, R. F., Guan, W., Pankow, J. S., Boerwinkle, E., Mosley, T. H., & Fornage, M. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0302-6 · Cited by 67 · see citing works

Latent Regulatory Potential of Human-Specific Repetitive Elements

Ward, M. C., Wilson, M. D., Barbosa‐Morais, N. L., Schmidt, D., Stark, R., Pan, Q., Schwalie, P. C., Menon, S., Lukk, M., Watt, S. B., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.013 · Cited by 66 · see citing works

DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes

Gaidatzis, D., Burger, L., Murr, R., Lerch, A., Dessus-Babus, S., Schübeler, D., & Stadler, M. B. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004143 · Cited by 66 · see citing works

Cell and tissue type independent age-associated DNA methylation changes are not rare but common

Zhu, T., Zheng, S., Paul, D. S., Horvath, S., & Teschendorff, A. E. (2018) · Aging · doi:10.18632/aging.101666 · Cited by 65 · see citing works

Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging

Oh, G., Ebrahimi, S. B., Carlucci, M., Zhang, A., Nair, A., Groot, D. E., Labrie, V., Jia, P., Oh, E. S., Jeremian, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03073-7 · Cited by 64 · see citing works

Isolation and identification of age-related DNA methylation markers for forensic age-prediction.

Yi, S.-H., Xu, L.-C., Mei, K., Yang, R.-Z., & Huang, D.-X. (2014) · Forensic Science International: Genetics · doi:10.1016/j.fsigen.2014.03.006 · Cited by 62 · see citing works

Longitudinal personal DNA methylome dynamics in a human with a chronic condition

Chen, R., Lin, X., Tu, K., Duan, M., Kukurba, K. R., Li‐Pook‐Than, J., Xie, D., & Snyder, M. P. (2018) · Nature Medicine · doi:10.1038/s41591-018-0237-x · Cited by 61 · see citing works

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L. J., Eckert, D., Hebisch, M., Fischer, J., Kesavan, J., Weykopf, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06398-5 · Cited by 58 · see citing works

Estimation of chimpanzee age based on DNA methylation

Ito, H., Udono, T., Hirata, S., & Inoue‐Murayama, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-28318-9 · Cited by 53 · see citing works

Genotype effects contribute to variation in longitudinal methylome patterns in older people

Zhang, Q., Marioni, R. E., Robinson, M. R., Higham, J., Sproul, D., Wray, N. R., Deary, I. J., McRae, A. F., & Visscher, P. M. (2018) · Genome Medicine · doi:10.1186/s13073-018-0585-7 · Cited by 47 · see citing works

Evaluation of three statistical prediction models for forensic age prediction based on DNA methylation

Smeers, I., Decorte, R., de Voorde, W. V., & Bekaert, B. (2018) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2018.02.008 · Cited by 45 · see citing works

Epigenetic Discrimination: Emerging Applications of Epigenetics Pointing to the Limitations of Policies Against Genetic Discrimination

Dupras, C., Song, L., Saulnier, K. M., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00202 · Cited by 44 · see citing works

Epigenetic age is a cell‐intrinsic property in transplanted human hematopoietic cells

Søraas, A. V. L., Matsuyama, M., Lima, M. J. G. D., Wald, D. N., Buechner, J., Gedde‐Dahl, T., Søraas, C. L., Chen, B. H., Ferrucci, L., Dahl, J. A., et al. (2019) · Aging Cell · doi:10.1111/acel.12897 · Cited by 44 · see citing works

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

Belsky, D. W., Caspi, A., Arseneault, L., Baccarelli, A., Corcoran, D. L., Gao, X., Hannon, E., Harrington, H. L., Rasmussen, L. J., Houts, R., et al. (2020) · eLife · doi:10.7554/elife.54870 · Cited by 652 · see citing works

Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality

Tian, Y. E., Cropley, V., Maier, A. B., Lautenschlager, N. T., Breakspear, M., & Zalesky, A. (2023) · Nature Medicine · doi:10.1038/s41591-023-02296-6 · Cited by 618 · see citing works

Measuring biological age using omics data

Rutledge, J., Oh, H., & Wyss-Coray, T. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00511-7 · Cited by 570 · see citing works

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499 · see citing works

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.

Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454 · see citing works

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367 · see citing works

Making sense of the ageing methylome

Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00477-6 · Cited by 274 · see citing works

Inflammation and DNA damage: cause, effect or both

Pezone, A., Olivieri, F., Napoli, M. V., Procopio, A., Avvedimento, E. V., & Gabrielli, A. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00905-1 · Cited by 212 · see citing works

BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy

Meyer, D. H., & Schumacher, B. (2021) · Aging Cell · doi:10.1111/acel.13320 · Cited by 165 · see citing works

Age-related DNA methylation changes are sex-specific: a comprehensive assessment

Yusipov, I., Bacalini, M. G., Kalyakulina, A., Krivonosov, M., Pirazzini, C., Gensous, N., Ravaioli, F., Milazzo, M., Giuliani, C., Vedunova, M., et al. (2020) · Aging · doi:10.18632/aging.202251 · Cited by 148 · see citing works

The Information Theory of Aging

Lu, Y. R., Tian, X., & Sinclair, D. A. (2023) · Nature Aging · doi:10.1038/s43587-023-00527-6 · Cited by 141 · see citing works

Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial

Bischoff-Ferrari, H. A., Gängler, S., Wieczorek, M., Belsky, D. W., Ryan, J., Kressig, R. W., Stähelin, H. B., Theiler, R., Dawson-Hughes, B., Rizzoli, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00793-y · Cited by 140 · see citing works

Psychological and biological resilience modulates the effects of stress on epigenetic aging

Harvanek, Z. M., Fogelman, N., Xu, K., & Sinha, R. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01735-7 · Cited by 123 · see citing works

The role of epigenetics in psychological resilience

Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30515-0 · Cited by 108 · see citing works

Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice.

Macip, C. C., Hasan, R., Hoznek, V., Kim, J., Metzger, L. E., Sethna, S., & Davidsohn, N. (2023) · doi:10.1101/2023.01.04.522507 · Cited by 95 · see citing works

A panoramic view of cell population dynamics in mammalian aging

Zhang, Z., Schaefer, C., Jiang, W., Lu, Z., Lee, J., Sziraki, A., Abdulraouf, A., Wick, B., Haeussler, M., Li, Z., et al. (2025) · Science · doi:10.1126/science.adn3949 · Cited by 95 · see citing works

Gene Therapy-Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice

Macip, C. C., Hasan, R., Hoznek, V., Kim, J., Lu, Y. R., Metzger, L. E., Sethna, S., & Davidsohn, N. (2024) · Cellular Reprogramming · doi:10.1089/cell.2023.0072 · Cited by 95 · see citing works

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression

Kabacik, S., Horvath, S., Cohen, H., & Raj, K. (2018) · Aging · doi:10.18632/aging.101588 · Cited by 68 · see citing works

Cardiovascular disease and the biology of aging

Moturi, S., Ghosh-Choudhary, S. K., & Finkel, T. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.04.005 · Cited by 56 · see citing works

DNA repair‐deficient premature aging models display accelerated epigenetic age

Perez, K., Parras, A., Picó, S., Rechsteiner, C., Haghani, A., Brooke, R., Mrabti, C., Schoenfeldt, L., Horvath, S., & Ocampo, A. (2024) · Aging Cell · doi:10.1111/acel.14058 · Cited by 31 · see citing works

Severe drought exposure in utero associates to children’s epigenetic age acceleration in a global climate change hot spot

Qiao, X., Straight, B., Ngo, D., Hilton, C. E., Owuor Olungah, C., Naugle, A., Lalancette, C., & Needham, B. L. (2024) · Nature Communications · doi:10.1038/s41467-024-48426-7 · Cited by 10 · see citing works

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older — China, 1998–2018

Zhou, J., Gao, X., Wei, Y., et al. (2023) · China CDC Weekly · doi:10.46234/ccdcw2023.005 · Cited by 2 · see citing works

Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity

Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26

Influence of Temperature and Nutrition on Adult Longevity of Microplitis tuberculiferWesmael

Li, J. (2010) · Journal of Hebei Agricultural Sciences · Cited by 1 · see citing works

Predictors of Exceptional Longevity: Gender Differences in Effects of Early-Life and Midlife Conditions

Gavrilov, L. A., & Gavrilova, N. S. (2016) · Applied demography series · doi:10.1007/978-3-319-43688-3_6 · Cited by 1 · see citing works

Longevity, Biological

Carnes, B. A. (2015) · The Encyclopedia of Adulthood and Aging · doi:10.1002/9781118521373.wbeaa004