Chamberlain, Jeffrey S.

Systemic delivery of genes to striated muscles using adeno-associated viral vectors

Gregorevic, P., Blankinship, M. J., Allen, J. M., Crawford, R. W., Meuse, L., Miller, D. G., Russell, D. W., & Chamberlain, J. S. (2004) · Nature Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 620

Animal models for muscular dystrophy show different patterns of sarcolemmal disruption

Straub, V., Rafael, J. A., Chamberlain, J. S., & Campbell, K. P. (1997) · The Journal of Cell Biology

Muscle Physiology and DisordersCardiomyopathy and Myosin Studies

Cited by 488

High levels of AAV vector integration into CRISPR-induced DNA breaks

Hanlon, K. S., Kleinstiver, B. P., Garcia, S. P., Zaborowski, M. P., Volak, A., Spirig, S. E., Muller, A., Sousa, A. A., Tsai, S. Q., Bengtsson, N. E., et al. (2019) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 431

Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy

Bengtsson, N. E., Hall, J. K., Odom, G. L., Phelps, M. P., Andrus, C. R., Hawkins, R. D., Hauschka, S. D., Chamberlain, J. R., & Chamberlain, J. S. (2017) · Nature Communications

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 387

Cas9 immunity creates challenges for CRISPR gene editing therapies

Crudele, J. M., & Chamberlain, J. S. (2018) · Nature Communications

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 259

Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle

Salva, M. Z., Himeda, C. L., Tai, P. W., Nishiuchi, E., Gregorevic, P., Allen, J. M., Finn, E. E., Nguyen, Q. G., Blankinship, M. J., Meuse, L., et al. (2007) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 232

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors

Lai, Y., Yue, Y., Liu, M., Ghosh, A., Engelhardt, J. F., Chamberlain, J. S., & Duan, D. (2005) · Nature Biotechnology

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 224

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Winbanks, C. E., Weeks, K. L., Thomson, R. E., Sepulveda, P. V., Beyer, C., Qian, H., Chen, J. L., Allen, J. M., Lancaster, G. I., Febbraio, M. A., et al. (2012) · Journal of Cell Biology

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 218

Adeno-Associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury

Liu, M., Yue, Y., Harper, S. Q., Grange, R. W., Chamberlain, J. S., & Duan, D. (2005) · Molecular Therapy

Virus-based gene therapy researchMuscle Physiology and Disorders

Cited by 178

Systemic Microdystrophin Gene Delivery Improves Skeletal Muscle Structure and Function in Old Dystrophic mdx Mice

Gregorevic, P., Blankinship, M. J., Allen, J. M., & Chamberlain, J. S. (2008) · Molecular Therapy

Virus-based gene therapy researchMuscle Physiology and Disorders

Cited by 120

Skeletal Muscle Contractions Induce Acute Changes in Cytosolic Superoxide, but Slower Responses in Mitochondrial Superoxide and Cellular Hydrogen Peroxide

Pearson, T., Kabayo, T., Ng, R., Chamberlain, J., McArdle, A., & Jackson, M. J. (2014) · PLoS ONE

Exercise and Physiological ResponsesRedox biology and oxidative stress

Cited by 107

Gene Therapy of mdx Mice With Large Truncated Dystrophins Generated by Recombination Using rAAV6

Odom, G. L., Gregorevic, P., Allen, J. M., & Chamberlain, J. S. (2011) · Molecular Therapy

Virus-based gene therapy researchNeurogenetic and Muscular Disorders Research

Cited by 95

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

Davey, J. R., Watt, K. I., Parker, B. L., Chaudhuri, R., Ryall, J. G., Cunningham, L., Qian, H., Sartorelli, V., Sandri, M., Chamberlain, J., et al. (2016) · JCI Insight

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 51

Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration

Pisconti, A., Banks, G. B., Babaeijandaghi, F., Betta, N. D., Rossi, F. M. V., Chamberlain, J. S., & Olwin, B. B. (2016) · Skeletal Muscle

Muscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

Cited by 50

Evaluation of vascular delivery methodologies to enhance rAAV6-mediated gene transfer to canine striated musculature

Gregorevic, P., Schultz, B. R., Allen, J. M., Halldorson, J. B., Blankinship, M. J., Meznarich, N. A., Kuhr, C. S., Doremus, C., Finn, E., Liggitt, D., et al. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 40

Surrogate gene therapy for muscular dystrophy

Davies, K. E., & Chamberlain, J. S. (2019) · Nature Medicine

Muscle Physiology and DisordersVirus-based gene therapy research

Cited by 11