Timmer, J.

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

Raue, A., Kreutz, C., Maiwald, T., Bachmann, J., Schilling, M., Klingmüller, U., & Timmer, J. (2009) · Bioinformatics

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 1,442

WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism

Sick, S., Reinker, S., Timmer, J., & Schlake, T. (2006) · Science

Hair Growth and DisordersWnt/β-catenin signaling in development and cancer

Cited by 612

Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling

Swameye, I., Müller, T. G., Timmer, J., Sandra, O., & Klingmüller, U. (2003) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsGene Regulatory Network Analysis

Cited by 316

Systems biology: experimental design

Kreutz, C., & Timmer, J. (2009) · The FEBS Journal

Optimal Experimental Design MethodsGene Regulatory Network Analysis

Cited by 257

Dynamical modeling and multi-experiment fitting with PottersWheel

Maiwald, T., & Timmer, J. (2008) · Bioinformatics

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 231

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Goldmann, T., Zeller, N., Raasch, J., Kierdorf, K., Frenzel, K., Ketscher, L., Basters, A., Staszewski, O., Brendecke, S. M., Spiess, A., et al. (2015) · The EMBO Journal

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 223

Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

Borisov, N., Aksamitiene, E., Kiyatkin, A., Legewie, S., Berkhout, J., Maiwald, T., Kaimachnikov, N. P., Timmer, J., Hoek, J. B., & Kholodenko, B. N. (2009) · Molecular Systems Biology

Protein Kinase Regulation and GTPase SignalingGene Regulatory Network Analysis

Cited by 222

Assessing the strength of directed influences among neural signals using renormalized partial directed coherence

Schelter, B., Timmer, J., & Eichler, M. (2009) · Journal of Neuroscience Methods

Functional Brain Connectivity StudiesNeural dynamics and brain function

Cited by 214

Data-based identifiability analysis of non-linear dynamical models

Hengl, S., Kreutz, C., Timmer, J., & Maiwald, T. (2007) · Bioinformatics

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 166

Addressing parameter identifiability by model-based experimentation

Raue, A., Kreutz, C., Maiwald, T., Klingmüller, U., & Timmer, J. (2011) · IET Systems Biology

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 145

Simulation methods for optimal experimental design in systems biology

Faller, D., Klingmüller, U., & Timmer, J. (2003) · SIMULATION

Optimal Experimental Design MethodsGene Regulatory Network Analysis

Cited by 137

Identifiability and observability analysis for experimental design in nonlinear dynamical models

Raue, A., Becker, V., Klingmüller, U., & Timmer, J. (2010) · Chaos: An Interdisciplinary Journal of Nonlinear Science

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 137

Pathological tremors: deterministic chaos or nonlinear stochastic oscillators?

Timmer, J., Häussler, S., Lauk, M., & Lücking, C.-H. (2000) · Chaos: An Interdisciplinary Journal of Nonlinear Science

Chaos control and synchronizationMotor Control and Adaptation

Cited by 130

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

Klingmüller, U., Bauer, A., Bohl, S., Nickel, P. J., Breitkopf, K., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., et al. (2006) · IEE Proceedings - Systems Biology

Liver physiology and pathologyGene Regulatory Network Analysis

Cited by 127

Characteristics of hand tremor time series

Timmer, J., Gantert, C., Deuschl, G., & Honerkamp, J. (1993) · Biological Cybernetics

Motor Control and AdaptationBalance, Gait, and Falls Prevention

Cited by 112

An error model for protein quantification

Kreutz, C., Rodriguez, M. M. B., Maiwald, T., Seidl, M., Blum, H. E., Mohr, L., & Timmer, J. (2007) · Bioinformatics

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 107

Hybrid optimization method with general switching strategy for parameter estimation.

Balsa-Canto, E., Peifer, M., Banga, J. R., Timmer, J., & Fleck, C. (2008) · BMC Systems Biology

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 105

PEtab—Interoperable specification of parameter estimation problems in systems biology

Schmiester, L., Schälte, Y., Bergmann, F. T., Camba, T., Dudkin, E., Egert, J., Fröhlich, F., Fuhrmann, L., Hauber, A. L., Kemmer, S., et al. (2021) · PLOS Computational Biology

Gene Regulatory Network AnalysisScientific Computing and Data Management

Cited by 96

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kreutz, C., Kolch, W., Lehmann, W. D., Timmer, J., & Klingmüller, U. (2009) · Molecular Systems Biology

Gene Regulatory Network AnalysisProtein Kinase Regulation and GTPase Signaling

Cited by 79

Analyzing the dynamics of hand tremor time series

Gantert, C., Honerkamp, J., & Timmer, J. (1992) · Biological Cybernetics

Motor Control and AdaptationDeep Brain Stimulation and Movement Disorders

Cited by 74

Modeling the nonlinear dynamics of cellular signal transduction

TIMMER, J., MÜLLER, T. G., SWAMEYE, I., SANDRA, O., & KLINGMÜLLER, U. (2004) · International Journal of Bifurcation and Chaos

Gene Regulatory Network AnalysisCytokine Signaling Pathways and Interactions

Cited by 68

Tremor classification and tremor time series analysis

Deuschl, G., Lauk, M., & Timmer, J. (1995) · Chaos: An Interdisciplinary Journal of Nonlinear Science

Deep Brain Stimulation and Movement DisordersMotor Control and Adaptation

Cited by 66

A longitudinal study of tremor frequencies in Parkinson’s disease and essential tremor

Hellwig, B., Mund, P., Schelter, B., Guschlbauer, B., Timmer, J., & Lücking, C. H. (2009) · Clinical Neurophysiology

Deep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

Cited by 65

Predictive mathematical models of cancer signalling pathways

Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., & Klingmüller, U. (2012) · Journal of Internal Medicine

Gene Regulatory Network AnalysisMathematical Biology Tumor Growth

Cited by 63