Cited by 63Gene Regulatory Network AnalysisMathematical Biology Tumor GrowthBioinformatics and Genomic Networks

Predictive mathematical models of cancer signalling pathways

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Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., Klingmüller, U.·2012·Journal of Internal Medicine

Abstract

Abstract. Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U (German Cancer Research Center, Heidelberg; BIOSS Centre for Biological Signalling Studies, Freiburg; and University of Freiburg, Freiburg; Germany). Predictive mathematical models of cancer signalling pathways (Key Symposium). J Intern Med 2012; 271:155–165. Complex intracellular signalling networks integrate extracellular signals and convert them into cellular responses. In cancer cells, the tightly regulated and fine‐tuned dynamics of information processing in signalling networks is altered, leading to uncontrolled cell proliferation, survival and migration. Systems biology combines mathematical modelling with comprehensive, quantitative, time‐resolved data and is most advanced in addressing dynamic properties of intracellular signalling networks. Here, we introduce different modelling approaches and their application to medical systems biology, focusing on the identifiability of parameters in ordinary differential equation models and their importance in network modelling to predict cellular decisions. Two related examples are given, which include processing of ligand‐encoded information and dual feedback regulation in erythropoietin (Epo) receptor signalling. Finally, we review the current understanding of how systems biology could foster the development of new treatment strategies in the context of lung cancer and anaemia.

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  1. Korf U, Derdak S, Tresch A et al. Quantitative protein micro- arrays for time-resolved measurements of protein phosphoryla- tion. Proteomics 2008; 8: 4603-12.

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Authors
Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., & Klingmüller, U.
Affiliations
  • German Cancer Research Center (DE)
  • University of Freiburg (DE)
  • Harvard University (US)
Corresponding author
Klingmüller, U.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2012-01-17
Volume
271
Issue
2
Pages
155-165
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W1855678235
Cited by
63
References
52
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 4 · 2013: 7 · 2012: 1
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • OPUS (Augsburg University) (submittedVersion)
Funders
Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
  • Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
cancer pathways, mathematical modeling, ordinary differential equation model, parameter identifiability, systems biology, lung cancer, anemia, cell proliferation
MeSH terms
Anemia, Antineoplastic Agents, Cell Survival, Erythropoietin, Forecasting, Humans, Lung Neoplasms, Mathematics, Models, Biological, Recombinant Proteins, Risk Factors, Transcription Factors, Signal Transduction, Likelihood Functions, Cytokines, Receptors, Erythropoietin, Systems Biology

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