Predictive mathematical models of cancer signalling pathways
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Abstract. Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U (German Cancer Research Center, Heidelberg; BIOSS Centre for Biological Signalling Studies, Freiburg; and University of Freiburg, Freiburg; Germany). Predictive mathematical models of cancer signalling pathways (Key Symposium). J Intern Med 2012; 271:155–165. Complex intracellular signalling networks integrate extracellular signals and convert them into cellular responses. In cancer cells, the tightly regulated and fine‐tuned dynamics of information processing in signalling networks is altered, leading to uncontrolled cell proliferation, survival and migration. Systems biology combines mathematical modelling with comprehensive, quantitative, time‐resolved data and is most advanced in addressing dynamic properties of intracellular signalling networks. Here, we introduce different modelling approaches and their application to medical systems biology, focusing on the identifiability of parameters in ordinary differential equation models and their importance in network modelling to predict cellular decisions. Two related examples are given, which include processing of ligand‐encoded information and dual feedback regulation in erythropoietin (Epo) receptor signalling. Finally, we review the current understanding of how systems biology could foster the development of new treatment strategies in the context of lung cancer and anaemia.
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To obtain a predictive mathematical model, the relation of considered species and experimentally measured components as well as the amount of experimental data needs to be appropriate.
“To obtain a predictive mathematical model, the relation of considered species and experimentally measured components as well as the amount of experimental data needs to be appropriate”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Bachmann et al., 2012
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Sensitivity of signaling pathway dynamics to plasmid transfection and its consequences
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Modelling Molecular Mechanisms of Cancer Pathogenesis: Virtual Patients, Real Opportunities
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Cancer Growth Inhibition Using Predictive Mathematical Models of Signaling Pathways
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- Authors
- Bachmann, J., Raue, A., Schilling, M., Becker, V., Timmer, J., & Klingmüller, U.
- Affiliations
- German Cancer Research Center (DE)
- University of Freiburg (DE)
- Harvard University (US)
- Corresponding author
- Klingmüller, U.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2012-01-17
- Volume
- 271
- Issue
- 2
- Pages
- 155-165
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1855678235
- Cited by
- 63
- References
- 52
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 4 · 2013: 7 · 2012: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- nbn-resolving.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- cancer pathways, mathematical modeling, ordinary differential equation model, parameter identifiability, systems biology, lung cancer, anemia, cell proliferation
- MeSH terms
- Anemia, Antineoplastic Agents, Cell Survival, Erythropoietin, Forecasting, Humans, Lung Neoplasms, Mathematics, Models, Biological, Recombinant Proteins, Risk Factors, Transcription Factors, Signal Transduction, Likelihood Functions, Cytokines, Receptors, Erythropoietin, Systems Biology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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