WNT and DKK determine hair follicle spacing through a reaction-diffusion mechanism

The simulation model by Sick et al. 2006 [31] contains only Wnt and its antagonist Dkk.

“There are two exceptions: the simulation model by Sick et al. 2006 [31] contains only Wnt and its antagonist Dkk and the model by Rodríguez-González et al. (2007) [33] lacks β-catenin.”

The number of species in the surveyed models, without considering compounds or different attributes or states such as phosphorylation state, ranges from 2 (in [31]) to 30 (in [53]).

“The number of species without considering compounds or different attributes or states, such as the phosphorylation state, ranges from 2 (in [31]) to 30 (in [53]).”

Six out of 19 publications recorded their own wet-lab data [28, 31, 32, 45, 51, 57].

“When looking at Wet-lab Data, six out of 19 publications recorded their own wet-lab data [28, 31, 32, 45, 51, 57].”

All other models are not part of a cluster and are either completely disconnected from the other studies [31] or include E-cadherin and the cell cycle [39] or just E-cadherin [49].

“All other models are not part of a cluster and are either completely disconnected from the other studies [31] or include E-cadherin and the cell cycle [39] or just E-cadherin [49].”

The two simulation models not linked to Lee et al. (2003) are those by Sick et al. (2006) and by Rodríguez-González et al. (2007).

“The two exceptions not linked to Lee et al. (2003) [28] are the simulation models by Sick et al. (2006) [31] and by Rodríguez-González et al. (2007) [33].”

Sick et al. (2006) [31] used arbitrary parameter values in their simulation models.

“Sick et al. (2006) [31] used arbitrary parameter values in their simulation models.”