Sawaya, Michael R.

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

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The expanding amyloid family: Structure, stability, function, and pathogenesis

Sawaya, M. R., Hughes, M. P., Rodriguez, J. A., Riek, R., & Eisenberg, D. S. (2021) · Cell

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 475

An open and closed case for all polymerases

Doublié, S., Sawaya, M. R., & Ellenberger, T. (1999) · Structure

Enzyme Structure and FunctionHIV/AIDS drug development and treatment

Cited by 314

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 292

Discovery and characterization of a unique mycobacterial heme acquisition system

Tullius, M. V., Harmston, C. A., Owens, C. P., Chim, N., Morse, R. P., McMath, L. M., Iniguez, A., Kimmey, J. M., Sawaya, M. R., Whitelegge, J. P., et al. (2011) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyIron Metabolism and Disorders

Cited by 199

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

Boyer, D. R., Li, B., Sun, C., Fan, W., Zhou, K., Hughes, M. P., Sawaya, M. R., Jiang, L., & Eisenberg, D. S. (2020) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 179

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

Griner, S. L., Seidler, P., Bowler, J., Murray, K. A., Yang, T. P., Sahay, S., Sawaya, M. R., Cascio, D., Rodriguez, J. A., Philipp, S., et al. (2019) · eLife

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 121

Derepression by Depolymerization

Qiao, F., Song, H., Kim, C. A., Sawaya, M. R., Hunter, J. B., Gingery, M., Rebay, I., Courey, A. J., & Bowie, J. U. (2004) · Cell

Genomics and Chromatin DynamicsProtein Kinase Regulation and GTPase Signaling

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Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design

Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., et al. (2018) · Nature Chemistry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples

Seidler, P. M., Boyer, D. R., Murray, K. A., Yang, T. P., Bentzel, M., Sawaya, M. R., Rosenberg, G., Cascio, D., Williams, C. K., Newell, K. L., et al. (2019) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold

Castells-Graells, R., Meador, K., Arbing, M. A., Sawaya, M. R., Gee, M., Cascio, D., Gleave, E., Debreczeni, J. É., Breed, J., Leopold, K., et al. (2023) · Proceedings of the National Academy of Sciences

Advanced Electron Microscopy Techniques and ApplicationsEnzyme Structure and Function

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Novel Mechanism of Hemin Capture by Hbp2, the Hemoglobin-binding Hemophore from Listeria monocytogenes

Malmirchegini, G. R., Sjodt, M., Shnitkind, S., Sawaya, M. R., Rosinski, J., Newton, S. M., Klebba, P. E., & Clubb, R. T. (2014) · Journal of Biological Chemistry

Hemoglobin structure and functionIron Metabolism and Disorders

Cited by 33

Structure and Mechanism of LcpA, a Phosphotransferase That Mediates Glycosylation of a Gram-Positive Bacterial Cell Wall-Anchored Protein

Siegel, S. D., Amer, B. R., Wu, C., Sawaya, M. R., Gosschalk, J. E., Clubb, R. T., & Ton-That, H. (2019) · mBio

Bacterial Genetics and BiotechnologyBiochemical and Structural Characterization

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De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Tetreau, G., Sawaya, M. R., De Zitter, E., Andreeva, E. A., Banneville, A.-S., Schibrowsky, N. A., Coquelle, N., Brewster, A. S., Grünbein, M. L., Kovacs, G. N., et al. (2022) · Nature Communications

Enzyme Structure and FunctionInsect Resistance and Genetics

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De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals

Tetreau, G., Sawaya, M. R., De Zitter, E., Andreeva, E. A., Banneville, A.-S., Schibrowsky, N., Coquelle, N., Brewster, A. S., Grünbein, M. L., Kovacs, G. N., et al. (2021) · Nature Communications

Enzyme Structure and FunctionInsect Resistance and Genetics

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A suite of designed protein cages using machine learning and protein fragment-based protocols

Meador, K., Castells-Graells, R., Aguirre, R., Sawaya, M. R., Arbing, M. A., Sherman, T., Senarathne, C., & Yeates, T. O. (2024) · Structure

Protein Structure and DynamicsEnzyme Structure and Function

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A Suite of Designed Protein Cages Using Machine Learning Algorithms and Protein Fragment-Based Protocols

Meador, K., Castells-Graells, R., Aguirre, R., Sawaya, M. R., Arbing, M. A., Sherman, T., Senarathne, C., & Yeates, T. O. (2023) · Structure

Protein Structure and DynamicsEnzyme Structure and Function

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