Locasale, Jason W.

The Warburg Effect: How Does it Benefit Cancer Cells?

Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 5,150

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 2,043

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell

Cancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

Cited by 1,462

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,120

Glutamine Metabolism in Cancer: Understanding the Heterogeneity

Cluntun, A. A., Lukey, M. J., Cerione, R. A., & Locasale, J. W. (2017) · Trends in Cancer

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 796

Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation

Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 638

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

Yu, Y.-R., Imrichova, H., Wang, H., Chao, T., Xiao, Z., Gao, M., Rincon-Restrepo, M., Franco, F., Genolet, R., Cheng, W.-C., et al. (2020) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 593

T cell stemness and dysfunction in tumors are triggered by a common mechanism

Vodnala, S. K., Eil, R., Kishton, R. J., Sukumar, M., Yamamoto, T. N., Ha, N.-H., Lee, P.-H., Shin, M., Patel, S. J., Yu, Z., et al. (2019) · Science

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 552

Metabolic landscape of the tumor microenvironment at single cell resolution

Xiao, Z., Dai, Z., & Locasale, J. W. (2019) · Nature Communications

Cancer, Hypoxia, and MetabolismSingle-cell and spatial transcriptomics

Cited by 524

The impact of cellular metabolism on chromatin dynamics and epigenetics

Reid, M. A., Dai, Z., & Locasale, J. W. (2017) · Nature Cell Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 515

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

McDonald, O. G., Li, X., Saunders, T., Tryggvadottir, R., Mentch, S. J., Warmoes, M. O., Word, A. E., Carrer, A., Salz, T. H., Natsume, S., et al. (2017) · Nature Genetics

Epigenetics and DNA MethylationPancreatic and Hepatic Oncology Research

Cited by 494

Metabolomics: A Primer

Liu, X., & Locasale, J. W. (2017) · Trends in Biochemical Sciences

Metabolomics and Mass Spectrometry StudiesAdvanced Proteomics Techniques and Applications

Cited by 453

Metabolic flux and the regulation of mammalian cell growth

Locasale, J. W., & Cantley, L. C. (2011) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 449

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Hu, J., Locasale, J. W., Bielas, J. H., O'Sullivan, J., Sheahan, K., Cantley, L. C., Heiden, M. G. V., & Vitkup, D. (2013) · Nature Biotechnology

Cancer, Hypoxia, and MetabolismBioinformatics and Genomic Networks

Cited by 407

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

Pan, M., Reid, M. A., Lowman, X. H., Kulkarni, R. P., Tran, T. Q., Liu, X., Yang, Y., Hernandez-Davies, J. E., Rosales, K. K., Li, H., et al. (2016) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 368

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

Shats, I., Williams, J. G., Liu, J., Makarov, M. V., Wu, X., Lih, F. B., Deterding, L. J., Lim, C., Xu, X., Randall, T. A., et al. (2020) · Cell Metabolism

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 242

Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity

Wang, Q., Liberti, M. V., Liu, P., Deng, X., Liu, Y., Locasale, J. W., & Lai, L. (2017) · Cell Chemical Biology

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 147

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model

Martin, A. S., Abraham, D. M., Hershberger, K. A., Bhatt, D. P., Mao, L., Cui, H., Liu, J., Liu, X., Muehlbauer, M. J., Grimsrud, P. A., et al. (2017) · JCI Insight

Sirtuins and Resveratrol in MedicineGenetic Neurodegenerative Diseases

Cited by 128

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

Gut, P., Matilainen, S., Meyer, J. G., Pällijeff, P., Richard, J., Carroll, C. J., Euro, L., Jackson, C. B., Isohanni, P., Minassian, B. A., et al. (2020) · Nature Communications

Metabolism and Genetic DisordersMitochondrial Function and Pathology

Cited by 83

Interactions between epigenetics and metabolism in cancers

Yun, J., Johnson, J. L., Hanigan, C. L., & Locasale, J. W. (2012) · Frontiers in Oncology

Epigenetics and DNA MethylationCancer, Hypoxia, and Metabolism

Cited by 82

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

Mason, J. A., Cockfield, J. A., Pape, D. J., Meissner, H., Sokolowski, M. T., White, T. C., Valentín López, J. C., Liu, J., Liu, X., Martínez-Reyes, I., et al. (2021) · Cell Reports

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 64

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Hwang, I., Uchida, H., Dai, Z., Li, F., Sanchez, T., Locasale, J. W., Cantley, L. C., Zheng, H., & Paik, J. (2021) · Nature Communications

FOXO transcription factor regulationinterferon and immune responses

Cited by 61

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

Nam, H., Kundu, A., Karki, S., Brinkley, G. J., Chandrashekar, D. S., Kirkman, R. L., Liu, J., Liberti, M. V., Locasale, J. W., Mitchell, T., et al. (2021) · JCI Insight

Cancer, Hypoxia, and MetabolismTGF-β signaling in diseases

Cited by 36

Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases

Bechard, M. E., Word, A. E., Tran, A. V., Liu, X., Locasale, J. W., & McDonald, O. G. (2018) · Oncogene

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 35